A5100398639- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Biological and pharmacological studies of plants
- Cardiac Imaging and Diagnostics
- Esophageal Cancer Research and Treatment
- Renal cell carcinoma treatment
- Cardiomyopathy and Myosin Studies
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- Vascular anomalies and interventions
- Bladder and Urothelial Cancer Treatments
- Hip and Femur Fractures
- Cancer Genomics and Diagnostics
- Advanced Neural Network Applications
- Cancer Immunotherapy and Biomarkers
- Cardiovascular and Diving-Related Complications
- Advanced MRI Techniques and Applications
- Plant and animal studies
- Nanoplatforms for cancer theranostics
- Childhood Cancer Survivors' Quality of Life
- Cardiac Arrest and Resuscitation
- Luminescence and Fluorescent Materials
- Coronary Artery Anomalies
Shanghai Jiao Tong University
2010-2025
Fujian Medical University
2022-2025
Dongyang People's Hospital
2021-2025
Wenzhou Medical University
2021-2025
Fujian Provincial Cancer Hospital
2024-2025
Johns Hopkins Medicine
2024
Johns Hopkins University
2018-2024
Central South University
2024
Integrated Chinese Medicine (China)
2024
Guangxi University
2024
To elucidate the deregulated functional modules that drive clear cell renal carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration proteogenomic measurements uniquely protein dysregulation cellular mechanisms impacted by alterations, including...
In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined low-dose insulin reverses the catabolic state through suppression of hyperglucagonemia. Additionally, it mimics anabolic actions monotherapy and normalizes hemoglobin A1c far less glucose variability. We show that therapy, like insulin, levels a wide array hepatic intermediary metabolites in multiple chemical classes, including acylcarnitines, organic acids (tricarboxylic acid cycle intermediates),...
Non-clear cell renal carcinomas (non-ccRCCs) encompass diverse malignant and benign tumors. Refinement of differential diagnosis biomarkers, markers for early prognosis aggressive disease, therapeutic targets to complement immunotherapy are current clinical needs. Multi-omics analyses 48 non-ccRCCs compared with 103 ccRCCs reveal proteogenomic, phosphorylation, glycosylation, metabolic aberrations in RCC subtypes. RCCs high genome instability display overexpression IGF2BP3 PYCR1. Integration...
A kind of fiber-optic modulation-depth-tunable modulator is developed in this paper. In modulator, a magnetic fluid used as the cladding drawn fiber, which attenuates evanescent field when light guided fiber. Because attenuation depends on strength applied external field, emergent intensity from fiber modulated with change strength. The response times, i.e., span for to reach final steady value time turned or off, are evaluated quantitatively.
A new 9,10-dihydrophenanthrene,1,5-dihydroxy-3,4,7-trimethoxy-9,10-dihydrophenanthrene (1) was isolated and identified from the whole plants of Dendrobium moniliforme, as well 24 known compounds including hircinol (2), (2R*,3S*)-3-hydroxymethyl-9-methoxy-2-(4′-hydroxy-3′,5′-dimethoxyphenyl)-2,3,6,7-tetrahydro-phenanthro[4,3-b]furan-5,11-diol (3), diospyrosin (4), aloifol I (5), moscatilin (6), 3,4′-dihydroxy-3′,4,5-trimethoxybibenzyl (7), gigantol (8), 3,3′-dihydroxy-4,5-dimethoxybibenzyl...
Reduced blood flow and tissue oxygen tension conditions result from thrombotic vascular diseases such as myocardial infarction, stroke, peripheral disease. It is largely assumed that while platelet activation increased by an acute event, chronic inflammation, ischemia, the pathways responses are not themselves changed disease process. We, therefore, sought to determine whether phenotype altered hypoxic ischemic conditions.In a cohort of patients with metabolic artery disease, activity was...
High blood urea nitrogen (BUN) is associated with an elevated risk of mortality in various diseases, such as heart failure and pneumonia. Heart pneumonia are common comorbidities acute exacerbation chronic obstructive pulmonary disease (AECOPD). However, data on the relationship BUN levels patients AECOPD sparse. The purpose this study was to evaluate correlation between level in-hospital a cohort who presented at emergency department (ED).A total 842 were enrolled retrospective...
Abstract Background and Aims Patients with acute myeloid leukaemia (AML) suffer from severe myocardial injury during daunorubicin (DNR)-based chemotherapy are at high risk of cardiac mortality. The crosstalk between tumour cells cardiomyocytes might play an important role in chemotherapy-related cardiotoxicity, but this has yet to be demonstrated. This study aimed identify its underlying mechanism explore potential therapeutic targets. Methods Cardiac tissues were harvested AML patient after...
Renal cell therapy has shown clinical efficacy in the treatment of acute renal failure (ARF) and promise for end-stage disease (ESRD) by supplementing conventional small solute clearance (hemodialysis or hemofiltration) with endocrine metabolic function provided cells maintained an extracorporeal circuit. A major obstacle widespread adoption this therapeutic approach is lack a cryopreservable system to enable distribution, storage, use at point care facilities. This report details design,...
Few data on paediatric hypertrophic cardiomyopathy (HCM) are available in developing countries. A multicentre, retrospective, cohort study was conducted to profile the clinical characteristics and survival of children with HCM China.We collected longitudinal aged 0-18 years at three participating institutions between January 1, 2010 December 31, 2019. Patients were identified by searching for diagnosis using ICD-10 codes from electronic medical records database. diagnosed morphologically...
Background Women with congenital heart disease are considered at high risk for adverse events. Therefore, we aim to establish 2 prediction models mothers and their offspring, which can predict the of events occurred in pregnant women disease. Methods Results A total 318 were included; 213 divided into development cohort, 105 validation cohort. Least absolute shrinkage selection operator was used predictor selection. After validation, multivariate logistic regression analysis develop model....
Segmentation of left and right ventricles from 3-D echocardiographic images is premised key for the quantitative analysis cardiac function, which important pediatric diagnosis. Compared with 2-D echocardiography, echocardiography can fully represent a ventricular structure without geometric inference. However, it usually takes experts several hours to obtain segmentation mask ventricles. Therefore, fast automatic method highly desired. Unfortunately, suffers low contrast, unclear borders,...
The effective enrichment and recovery of rare earth elements (REEs) from wastewater holds significant practical value for both the sustainable utilization REEs restoration ecological environments. In this study, magnetic zeolite was successfully synthesized by using tailings (RET) as raw material, with addition Fe3O4 to introduce a phase. Th exhibits high crystallinity, excellent thermal stability, substantial specific surface area 483.8 m2/g, rapid adsorption kinetics. maximum capacities...
Introduction Recently, immunotherapy has significantly transformed the treatment landscape of endometrial cancer (EC). Results from KEYNOTE-158, RUBY and AtTEnd showed programmed cell death 1 (PD-1) or death-ligand inhibitors with promising efficacy in primary advanced recurrent EC. However, few studies focused on role dual immune checkpoints Cadonilimab is an checkpoint inhibitor targeting PD-1 T-lymphocyte antigen-4, which expected to show substantial clinical Combining cadonilimab...
Standard echocardiographic view recognition is a prerequisite for automatic diagnosis of congenital heart defects (CHDs). This study aims to evaluate the feasibility and accuracy standard in CHDs children using convolutional neural networks (CNNs). A new deep learning-based network method was proposed automatically efficiently identify commonly used views. total 367,571 image slices from 3,772 subjects were train validate model where 23 views diagnose identified. The F1 scores majority all...
Photochemical afterglow materials have drawn considerable attention due to their attractive luminescent properties and great application potential. Considering the classical photochemical always exhibit poor luminescence, it is urgent gain fundamental understanding of main limiting factors. Here, we identified existence a dark-state triplet in process, an overwhelming percentage ~98.5% was revealed for this non-emissive state. Guided by these observations, proposed activate unprecedented...
Abstract Acute type A aortic dissection is a catastrophic cardiovascular event characterized by severe pain and hemodynamic instability. The standard of care emergency surgery, which, despite its benefits, carries substantial perioperative risks. Conservative management an alternative approach reserved for older patients with clinically significant comorbidities or whom surgical risk prohibitive mortality may outweigh potential benefits. case presented 75-year-old patient who opted...
Deep sternal wound infection (DSWI) caused by Mycoplasma hominis after cardiac surgery is very rare and easily overlooked. This paper reports the case of a patient with DSWI surgery. The had an unexplained fever postoperatively. On seventh day surgery, incision opened, there was pus leakage. 11th culture indicated infection. cured treatment omadacycline secondary