A5044606228- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Nanowire Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Genetic factors in colorectal cancer
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- DNA Repair Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Cancer, Hypoxia, and Metabolism
- Advanced Biosensing Techniques and Applications
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Developmental Biology and Gene Regulation
- Advanced Thermodynamic Systems and Engines
- Biochemical and Structural Characterization
Shanghai Children's Medical Center
2015-2024
Shanghai Jiao Tong University
2013-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2021-2024
National Health and Family Planning Commission
2023-2024
Zhejiang University
2017-2020
International Peace Maternity & Child Health Hospital
2020
Ruijin Hospital
2014
University of South China
2011
To assess whether vaginal secretions and breast milk of women with coronavirus disease 2019 (COVID-19) contain severe acute respiratory syndrome 2 (SARS-CoV-2).Single centre cohort study.Renmin Hospital Wuhan University, Wuhan, Hubei province, China.We studied 13 SARS-CoV-2-infected pregnant diagnosed between 31 January 9 March 2020.We collected clinical data, secretions, stool specimens from during different stages pregnancy neonatal throat anal swabs.We assessed viral presence in...
Abstract Background and Aims Patients with acute myeloid leukaemia (AML) suffer from severe myocardial injury during daunorubicin (DNR)-based chemotherapy are at high risk of cardiac mortality. The crosstalk between tumour cells cardiomyocytes might play an important role in chemotherapy-related cardiotoxicity, but this has yet to be demonstrated. This study aimed identify its underlying mechanism explore potential therapeutic targets. Methods Cardiac tissues were harvested AML patient after...
Bone marrow mesenchymal stem cells (BMSC) can differentiate into diverse cell types, including adipogenic, osteogenic, chondrogenic and myogenic lineages.There are lots of BMSC accumulated in atherosclerosis vessels VSMC.However, it is unclear whether VSMC originated from (BMSC-SMC) could remodel the vessel new tunica intima or promote pathogenesis atherosclerosis.In this study, were differentiated response to transforming growth factor β (TGF-β) shown express a number markers, such as...
Summary Poor graft function ( PGF ) is a severe complication of allogeneic haematopoietic stem cell transplantation (allo‐ HSCT ). Murine studies have demonstrated that effective haematopoiesis depends on the specific bone marrow BM microenvironment. Increasing evidence shows macrophages (MФs), which constitute an important component immune microenvironment, are indispensable for regulation cells HSC s) in . However, little known about number and MФs or whether they directly interact with s...
B-cell acute lymphocytic leukemia (B-ALL), a common blood cancer in children, leads to high mortality. Cyclin-dependent kinase 9 inhibitor (CDK9i) effectively attenuates myeloid and chronic lymphoblastic by inducing apoptosis inhibiting cell proliferation. However, the effect of CDK9i on B-ALL cells underlying mechanisms remain unclear. In this study, we showed that induced vitro activating apoptotic pathways. addition, restrained glycolytic metabolism cells, CDK9i-induced was enhanced...
Interleukin-2 (IL-2) is a pivotal cytokine that plays crucial role in the activation, proliferation, and functional regulation of multiple immune cells. High-dose IL-2 has been approved for antitumor therapy but may cause toxicity. levels within body are also associated with various pathological states, making it potential diagnostic prognostic biomarker. Consequently, development efficient tools rapid detection real-time quantification great significance. In this study, we identified two...
Abstract Although we previously reported that the self-renewal of leukemia-initiating cells B-lineage acute lymphoblastic leukemia (B-ALL LICs) was regulated by β -Arrestin1, a multiple-function protein, cellular senescence is critical for LICs fate and progress, worthy further investigation. Here found depletion β-Arrestin1 extended population doubling time percentage senile cells, signatures senescence, B-ALL LICs. Moreover, lack enhanced expression proteins (CBX, HIRA) genes ( P53 , P16 )...
Abstract Chimeric antigen receptor (CAR)‐positive cell therapy, specifically with anti‐CD19 CAR‐T (CAR19‐T) cells, achieves a high complete response during tumor treatment for hematological malignancies. Large‐scale production and application of therapy can be achieved by developing efficient low‐cost enrichment methods expansion monitoring in vivo, overcoming escape. Here, novel CAR‐specific binding aptamers (CAR‐ap) to traceless sort CAR‐positive cells obtain positive rate CAR19‐T is...
Considerable efforts have been devoted toward the uncovering of molecular mechanisms underlying maintenance hematopoietic stem cells (HSCs) by normal bone marrow (BM) niche. Previously, we demonstrated that a chemotherapy-induced niche, which is mainly composed mesenchymal (MSCs), protects residual B-cell acute lymphoblastic leukemia (B-ALL) from insult chemotherapeutic drugs. However, roles niche on HSCs functions in B-ALL remain unclear. We established an oncogenic N-MYC-driven mouse...
B-cell acute lymphocytic leukemia (B-ALL) is a malignant blood cancer that develops in children and adults leads to high mortality. THZ1, covalent cyclin-dependent kinase 7 (CDK7) inhibitor, shows anti-tumor effects various cancers by inhibiting cell proliferation inducing apoptosis. However, whether THZ1 has an inhibitory effect on B-ALL cells the underlying mechanism remains obscure. In this study, we showed arrested cycle of vitro low concentration, while apoptosis concentration...
Abstract Background Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal disorders characterized by ineffective haematopoiesis and immune deregulation. Emerging evidence has shown the effect bone marrow (BM) endothelial progenitor cells (EPCs) in regulating balance. However, number functions BM EPCs patients with different stages MDS remain largely unknown. Methods Patients (N = 30), de novo acute leukaemia (AML) 15), healthy donors (HDs) 15) were enrolled. divided...
Antibody (Ab)-based drugs have been widely used in targeted therapies and immunotherapies, leading to significant improvements tumor therapy. However, the failure of Ab therapy due loss target antigens or modifications that affect its function limits application. In this study, we expanded application antibodies (Abs) by constructing a fusion protein as versatile tool for Ab-based cell detection, delivery, We first constructed SpaC Catcher (SpaCC short) included C domains Staphylococcal A...
Summary Graft‐versus‐host disease ( GVHD ) is a major complication after allogeneic haematopoietic stem cell transplantation (allo‐ HSCT that frequently associated with bone marrow BM suppression, and clinical management challenging. endothelial progenitor cells EPC s) play crucial roles in the regulation of haematopoiesis thrombopoiesis. However, little known regarding functional s acute aGVHD patients. In current prospective case‐control study, reduced dysfunctional s, characterized by...
BACKGROUND:Acute lymphocytic leukemia (ALL) is a common blood cancer which induces high mortality in children. Bromodomains and extra-terminal (BET) protein inhibitors, such as JQ1 ARV-825, are promising therapeutic agents that can be used by targeting c-Myc. A recent work reported effectively attenuates ALL vitro suppressing cell proliferation accelerating apoptosis. The purpose of this research was to probe into the potential mechanism how inhibits vitro. MATERIAL AND METHODS:Cell...
Summary Severe acquired aplastic anaemia (AA) is a serious disease characterised by autoreactive T cells attacking haematopoietic stem cells, leading to marrow hypoplasia and pancytopenia. Immunosuppressive therapy combined with antithymocyte globulin ciclosporin can rescue most patients AA. However, the relapse after withdrawal severe side effects of long‐term administration remain unresolved. As such, new strategies should be developed supplement current therapeutics treat In this study,...