A5072292266- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Vascular anomalies and interventions
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Congenital heart defects research
- Anesthesia and Neurotoxicity Research
- Neonatal and fetal brain pathology
- Cardiovascular Function and Risk Factors
- Osteoarthritis Treatment and Mechanisms
- Gut microbiota and health
- Cardiac and Coronary Surgery Techniques
- Congenital Anomalies and Fetal Surgery
- Electrospun Nanofibers in Biomedical Applications
- Mechanical Circulatory Support Devices
- Sperm and Testicular Function
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
Shanghai Children's Medical Center
2016-2025
Shanghai Jiao Tong University
2014-2025
Houston Methodist
2024
Guangdong General Hospital
2016
Guangdong Academy of Medical Sciences
2016
Ideon Innovation (Sweden)
2015
Renji Hospital
2014
Huzhou Women and Children's Hospital
2008
XinHua Hospital
2005
Total anomalous pulmonary venous connection (TAPVC) is a rare form of congenital heart disease. This study describes current surgical treatment strategies and experiences in cohort patients from 2 cardiac centers Shanghai Guangdong China.This retrospective included 768 operated on between 2005 2014. Although most (n=690) underwent conventional repair, sutureless technique was used 10% (n=78) cases. A multilevel mixed-effects parametric survival model competing-risk analysis were to analyze...
Pressure-overloaded left ventricular remodeling in young population is progressive and readily degenerate into heart failure. The aims of this study were to identify a plasma metabolite that predicts mechanistically linked the disease. Untargeted metabolomics determined elevated kynurenine (Kyn) both patient cohorts mice model, which was correlated with parameters. In vitro vivo evidence, combined single-nucleus RNA sequencing (snRNA-seq), demonstrated Kyn affected cardiomyocytes cardiac...
Cartilage engineering strategies using mesenchymal stem cells (MSCs) could provide preferable solutions to resolve long-segment tracheal defects. However, the drawbacks of widely used chondrogenic protocols containing TGF-β3, such as inefficiency and unstable cellular phenotype, are problematic. In our research, optimize differentiation human umbilical cord MSCs (hUCMSCs), kartogenin (KGN) preconditioning was performed prior TGF-β3 induction. hUCMSCs were preconditioned with 1 µM KGN for 3...
Studies focused on pregnant women with congenital heart disease (CHD)-associated pulmonary hypertension (PH) are scarce and limited by small sample sizes single-center design. This study sought to describe the pregnancy outcomes in CHD without PH.
Cardiac fibrosis under chronic pressure overload is an end-stage adverse remodeling of heart. However, current heart failure treatments barely focus on anti-fibrosis and the effects are limited. We aimed to seek for a cardiac abundant specific piRNA, exploring its underlying mechanism therapeutic potential. Whole transcriptome sequencing following verification experiments identified highly upregulated piRNA (piRNA-000691) in transverse aortic constriction (TAC) mice, TAC pig, human samples,...
Background Recurrent pulmonary vein stenosis (PVS) following surgical repair of total anomalous venous connection is associated with poor prognosis. Preclinical studies have shown that use an angiotensin receptor blocker can attenuate intimal hyperplasia; notwithstanding, its clinical utility uncertain benefit. Methods This single‐center study included patients undergoing in 2020 to 2021. Since August 2020, been considered for valsartan therapy early after operation. Contemporaneous...
The optimal surgical strategies for pulmonary atresia with intact ventricular septum (PAIVS) are still not well established. This study reviewed our 15-year experience in the management of PAIVS. Between July 1999 and June 2014, 170 patients were treated PAIVS heart centre. Based on morphology right ventricle (RV), age approaches, divided into two groups: one-stage surgery group (n = 33) staged 137), which received definitive repair, including biventricular 1.5 repair univentricular...
The present study developed a cardiac extracellular matrix-chitosan-gelatin (cECM-CG) composite scaffold that can be used as tissue-engineered heart patch and investigated its endothelialization potential by incorporating CD34+ endothelial progenitor cells (EPCs). cECM-CG was prepared blending matrix (cECM) with biodegradable chitosan-gelatin (CG). mixture lyophilized using vacuum freeze-drying. EPCs were isolated seeded on the scaffolds, then effect subsequently investigated. Effects of...
Chronic hypoxia, common in neonates, disrupts gut microbiota balance, which is crucial for brain development. This study utilized cyanotic congenital heart disease (CCHD) patients and a neonatal hypoxic rat model to explore the association. Both rats CCHD infants exhibited immaturity, white matter injury (WMI), inflammation, motor/learning deficits. Through 16s rRNA sequencing metabolomic analysis, reduction
Various surgical techniques have been introduced to treat supravalvular aortic stenosis (SVAS). However, there is no consensus upon the optimal approach. This study reviewed our institutional experience in management of SVAS.Ninety patients undergoing surgery for SVAS were identified between 2009 and 2016. Based on techniques, divided into three groups: McGoon repair (n = 63), Doty 24), Brom 3). Median follow-up was 38.5 months (range, 4 months-7.5 years). Patient status, cumulative...
Abstract Small RNAs, especially the microRNAs, have been revealed to play great roles in heart development and congenital defects. Several studies shown dysregulated miRNAs ventricular tissues of Tetralogy Fallot (TOF) patients. In present study, we conducted high throughput sequencing obtain global profiling small RNA transcriptome right samples from 10 age -matched TOF These showed dominant composition miRNA mitochondrial associated RNAs. By sRNA cluster identification differential gene...
Abstract Objectives: To study the effects of a self-powered Fontan circulation in both idealized models and patient-specific models. Methods: In silico, conduit with nozzle was introduced from ascending aorta into anastomosis superior vena cava pulmonary artery. Computational fluid dynamics (CFD) simulation applied to calculate fields Three 3-dimentional different offsets were reconstructed by computer-aided design evaluate conduit. Furthermore, validate models, three offsets. Results: The...
To compare the safety and usefulness of deep hypothermic circulatory arrest (DHCA) regional cerebral perfusion (RCP) during pediatric open heart surgery. Between January 1, 2004 September 30, 2012, 1250 children with congenital cardiac defect underwent corrective operation DHCA or RCP technique in Shanghai Children's Medical Center. Of them, 947 cases aid (DHCA group), 303 (RCP group). The mean time was 30.64±15.81 (7–63) minutes 36.18±12.86 (10–82) minutes. mortality rate 7.18% (68/947)...