A5068137442- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Reproductive tract infections research
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Helicobacter pylori-related gastroenterology studies
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Hepatitis B Virus Studies
- Immune cells in cancer
- Bacterial Infections and Vaccines
- Clostridium difficile and Clostridium perfringens research
- Entomopathogenic Microorganisms in Pest Control
Southwest Medical University
2014-2025
Zhongshan Hospital of Xiamen University
2025
Shenzhen Children's Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Zhengzhou University
2013-2024
Henan Cancer Hospital
2012-2024
Songjiang District Central Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Children's Medical Center
2024
Hangzhou City University
2024
To evaluate Helicobacter pylori antibiotics resistance evolution from 2000 to 2009 amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin and moxifloxacin in Beijing, China.A total of 374 H. strains isolated subjects who had undergone upper gastrointestinal endoscopy were collected examined by E-test method for susceptibility.The average rates 0.3% (amoxicillin), 37.2% (clarithromycin), 63.9% (metronidazole), 1.2% (tetracycline), 50.3% (levofloxacin) 61.9% (moxifloxacin)....
The study aimed to predict acute radiation esophagitis (ARE) with grade ≥ 2 for patients locally advanced lung cancer (LALC) treated intensity-modulated therapy (IMRT) using multi-omics features, including radiomics and dosiomics.161 stage IIIA-IIIB LALC who received chemoradiotherapy (CRT) or radiotherapy by IMRT a prescribed dose from 45 70 Gy 2015 2019 were enrolled retrospectively. All the toxicity gradings given following Common Terminology Criteria Adverse Events V4.0. Multi-omics...
Abstract: Baicalin (BA) is a major constituent of Scutellaria baicalensis Georgi , medicinal herb. Previous pharmacokinetic studies BA showed its low oral bioavailability. The aim the present study was to develop novel BA-loaded liposome (BA-LP) enhance BA-LP, composed BA, Tween ® 80, Phospholipon 90H, and citric acid at weight ratio 96/50/96/50, respectively, prepared by effervescent dispersion technique characterized in terms morphology, size, zeta potential, encapsulation efficiency,...
Homeobox D gene cluster antisense growth-associated long noncoding RNA (HAGLR) functions as a crucial regulator in the progression and development of human cancers. We analyzed effects HAGLR, microRNA (miR)-143-5p lysosome-associated membrane glycoprotein (LAMP)3 on esophageal cancer (EC) related mechanisms. Microarray analysis was used to screen out EC-related genes regulation network among miR-143-5p, LAMP3. The regulatory mechanisms HAGLR miR-143-5p EC were following treatment mimic,...
Abstract Objectives Stereotactic body radiotherapy ( SBRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are unfit surgery. Some may experience distant metastasis. This study aimed to develop and validate radiomics model predicting metastasis in NSCLC treated SBRT. Methods Patients at five institutions were enrolled this study. Radiomics features extracted based on the PET/CT images. After feature selection training set (from Tianjin), CT-based...
The present study aims to develop a kind of novel nanoliposomes for the lung-targeting delivery system baicalin as Chinese medicine monomer. Baicalin-loaded were prepared by effervescent dispersion and lyophilized techniques. had an average particle size 131.7±11.7 nm with 0.19±0.02 polydispersity index, 82.8%±1.24% entrapment efficiency 90.47%±0.93% yield sustaining drug release effect over 24 h stable 12 months at least. In vitro no hemolytic activity was observed experimental...
Background: Increasing evidence indicates a relationship between systemic inflammation and survival following treatment in various tumors. However, the correlation of systematic with after stereotactic ablative radiotherapy (SABR) early stage non-small cell lung cancer (NSCLC) has not been well established. Patients methods: We retrospectively analyzed patients newly diagnosed NSCLC treated SABR single institution from 2011 to 2015. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte...
Backgrounds/Aims: MicroRNAs (miRs) often contribute to the progression of non-small cell lung cancer (NSCLC) via regulation mRNAs that are involved in homeostasis. We conducted a study aimed at exploring roles miR-183 proliferation, epithelial-mesenchymal transition (EMT), invasion and migration human NSCLC cells targeting MTA1. Methods: adjacent normal tissues were collected from 194 patients with NSCLC. Positive expression MTA1 protein was detected by immunohistochemistry. The highest...
Long non-coding RNA growth arrest-specific 5 (GAS5) has been demonstrated to be involved in the pathogenesis of atherosclerosis (AS). The purpose present study was investigate underlying mechanisms GAS5 on inflammation and lipid metabolic disorders AS. ApoE-/- mice were fed a high fat diet (HFD) THP-1 macrophages treated with ox-LDL construct AS model vivo vitro, respectively. detections blood lipids inflammatory cytokines performed using corresponding assay kits. qRT-PCR used assess...
Background A novel nanoemulsion (CU/FU-LN) was developed as an oral 5-fluorouracil and curcumin co-delivery system for synergistic efficacy against liver cancer.Methods MTT assay, confocal laser scanning microscope, H&E staining were utilized to establish the safety of CU/FU-LN.Results The AUC(0-t) CU/FU-LN 8.85-fold 8.59-fold greater than those CU FU, respectively. IC50 4.6-fold 4.9-fold lower FU in HepG2 cells, In vivo anti-tumor trials, tumor inhibition rate significantly elevated by...
Esophageal cancer represents the eighth most frequently occurring cancer, as well sixth widespread cause of cancer-related deaths. In recent years, accumulating evidence has implicated long non-coding RNAs in progression esophageal squamous cell carcinoma (ESCC). The aim present study was to investigate potential involvement and underlying mechanisms LINC00337 ESCC. Expression patterns targeting protein for Xenopus kinesin-like 2 (TPX2) ESCC tissues cells were detected using RT-qPCR...
Plasmacytoma variability translocation 1 (PVT1), an oncogene, has been reported to be highly expressed in many tumors, including human glioma, gastric cancer, and non-small cell lung cancer. Functionally, it could also regulate the development of tumor cells. However, its specific roles pathogenesis gliomas are still not clear. This study investigated function mechanism PVT1 knockdown proliferation malignant transformation gliomas. We first examined expression levels miR-424 glioma tissues...
Abstract Cortical disinhibition is a common feature of several neuropsychiatric diseases such as schizophrenia, autism and intellectual disabilities. However, the underlying mechanisms are not fully understood. To mimic increased expression Nrg1 , schizophrenia susceptibility gene in GABAergic interneurons from patients with we generated gto mice overexpression interneurons. showed cortical at cellular, synaptic, neural network behavioral levels. We revealed that intracellular domain NRG1...
Purpose: This study investigates the impact of lung function on radiation pneumonitis prediction using a dual-omics analysis method. Methods: We retrospectively collected data 126 stage III cancer patients treated with chemo-radiotherapy intensity-modulated radiotherapy, including pre-treatment planning CT images, radiotherapy dose distribution, and contours organs structures. Lung perfusion functional images were generated previously developed deep learning The whole (WL) volume was divided...
Purpose: To evaluate the effectiveness of features obtained from our proposed incremental-dose-interval-based lung subregion segmentation (IDLSS) for predicting grade ≥ 2 acute radiation pneumonitis (ARP) in cancer patients upon intensity-modulated radiotherapy (IMRT). (1) Materials and Methods: A total 126 non-small-cell treated with IMRT were retrospectively analyzed. Five subregions (SRs) generated by intersection whole (WL) five sub-regions receiving incremental dose intervals. 4610...