A5101945766- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Advanced biosensing and bioanalysis techniques
- Malaria Research and Control
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hormonal Regulation and Hypertension
- Advanced Nanomaterials in Catalysis
- Renin-Angiotensin System Studies
- Anesthesia and Sedative Agents
- Circular RNAs in diseases
- Mosquito-borne diseases and control
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Anesthesia and Pain Management
- Pancreatitis Pathology and Treatment
- Healthcare and Venom Research
- Parasites and Host Interactions
- Iron Metabolism and Disorders
- Apelin-related biomedical research
- Invertebrate Immune Response Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Computational Drug Discovery Methods
First Affiliated Hospital of Zhengzhou University
2012-2025
Tongji University
2008-2025
Binzhou University
2024
Binzhou Medical University
2024
Hainan Medical University
2024
Tongji Hospital
2024
Nanjing University
2024
First Affiliated Hospital of Wannan Medical College
2022-2024
Nanjing General Hospital of Nanjing Military Command
2024
Beijing Anzhen Hospital
2013-2023
Circular RNAs (circRNAs) have been implicated in the development and progression of gastric cancer (GC). However, it remains unclear whether dysregulated circRNA affects immune escape efficacy immunotherapy GC. Our aim is to investigate molecular mechanism affecting GC identify effective therapeutic targets.
The anti-inflammatory effects of O-1602 and cannabidiol (CBD), the ligands G protein-coupled receptor 55 (GPR55), on experimental acute pancreatitis (AP) were investigated.Acute was induced in C57BL mice by intraperitoneal injection 50 μg/kg cerulein hourly, with a total 6 times. Drugs (O-1602, 10 mg/kg, or CBD, 0.5 mg/kg) given 2 times at 30 minutes before first immediately fifth injection. At 3 hours after last injection, blood, lungs, pancreas harvested for pancreatic enzyme activity,...
Studies focused on pregnant women with congenital heart disease (CHD)-associated pulmonary hypertension (PH) are scarce and limited by small sample sizes single-center design. This study sought to describe the pregnancy outcomes in CHD without PH.
Objective:To evaluate the clinical effectiveness of laparoscopic management cesarean scar pregnancy (CSP) by deep implantation.Background:A implanting within from a previous delivery is rare condition ectopic pregnancy. There are two different types CSPs. Type I caused implantation amniotic sac on with progression toward either cervicoisthmic space or uterine cavity. II (CSP-II) into CS defect infiltrating growth myometrium and bulging serosal surface, which may result in rupture severe...
Aims Pulmonary arterial hypertension is a severe complication in patients with congenital heart disease and poses significant risk to women wishing become pregnant. This study describes the clinical presentation, maternal outcomes factors for peripartum period pulmonary related (PAH-CHD). Methods All pregnant PAH-CHD who were admitted delivery tertiary center between February 2011–September 2016 included. Logistic regression analysis was used identify predictors of combined endpoint death,...
Primary liver cancer is the sixth most common and third leading cause of cancer-related death worldwide. The role 'Other' subfamily HECT E3 ligases (E3s) in hepatocellular carcinoma (HCC) remains unknown. expression E3s was performed using Cancer Genome Atlas (TCGA) data, authors found that were differentially expressed HCC. Prognostic values assessed Kaplan-Meier method indicated high expressions HECTD2, HECTD3, HACE1 associated with a worse clinical prognosis HCC patients. HECTD2...
Abstract The combination of BRAF/MEK‐targeted therapy with immune checkpoint blockade is regarded as a promising regimen for patients metastatic melanoma due to their complementary advantages. However, MEK‐inhibitor‐induced T‐cell toxicity impedes effective cooperation. In this experiment, pH‐responsive on‐demand controlled release mesoporous silica nanoparticles (MSNPs) system designed. Fluorescein‐isothiocyanate‐loaded MSNP can be specifically delivered into tumor cells rather than...
<title>Abstract</title> Background It is currently established that artemisinin kills malaria parasites by disrupting iron or haem utilization. Similarly, chelators also eliminate these interfering with However, the antimalarial effect of significantly greater than chelators. Understanding differences between two mechanisms beneficial for elucidating action and developing strategies to enhance artemisinin-based combination therapies. Methods We employed single-cell RNA sequencing analysis...
Hemozoin is considered a waste byproduct of heme detoxification following hemoglobin digestion; consequently, the biological functions hemozoin in hemozoin-producing organisms have often been overlooked. However, recent findings indicate that Schistosoma facilitates transfer iron from erythrocytes to eggs through its formation and degradation, thereby increasing interest role malarial hemozoin. Using transmission electron microscopy, we compared malaria Through transcriptome analysis...
Introduction During sedation for gastroscopy, hypoxaemia represents the most common adverse event. The objective of this trial is to assess efficacy and safety bilevel positive airway pressure (BPAP) prevention hypoxaemia, in comparison with nasal cannula oxygen therapy, among patients predisposed during gastroscopy. Methods analysis This randomised controlled (RCT) will include 616 at risk when undergoing including those advanced age, frailty, American Society Anesthesiologists grades...
Abstract The liver-adipose axis serves as a fundamental regulatory network governing systemic lipid homeostasis, with hepatic-derived signals orchestrating adipose tissue plasticity through multimodal mechanisms. Comprehensive elucidation of these bidirectional crosstalk mechanisms may reveal novel therapeutic strategies for metabolic disorders. Our investigation demonstrates that cold exposure induces hepatic secretion exosomes potentiate thermogenic activation in both vitro and vivo...
As pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) may increase maternal and fetal risk, this study explored the pregnancy outcomes of Chinese women PAH-CHD. The clinical data pregnant PAH-CHD admitted to Beijing Anzhen Hospital from 2010 2019 were retrospectively analyzed; these patients their offspring followed up, a mean period 5.9 ± 2.7 years. Overall, 260 included. age was 27.7 4.1 years, 205 (78.8%) nulliparous. estimated systolic artery pressure...
Angiotensinogen (AGT) is the precursor of one most important vasoactive hormone angiotensin II and this gene locus associated with human essential hypertension. AGT an acute phase protein its expression regulated by IL-6. Previous studies have identified three potential STAT-3 binding sites (APREs) located between −160 −280 hAGT promoter but only APRE-1 (located −271 −279) was shown to be a bonafide enhancer for IL-6-induced activity. We show here that APRE-2, −236 −247, indeed...
The aim of the present study was to investigate role microRNA‑15a‑5p (miR‑15a‑5p) in pulmonary arterial hypertension (PAH) and elucidate underlying pro‑apoptotic mechanism. Reverse transcription‑quantitative PCR analysis gene microarray hybridization were used measure expression miR‑15a‑5p lung tissues rats with monocrotaline (MCT)‑induced PAH. Flow cytometry caspase‑3/9 activity assays adopted apoptosis artery smooth muscle cells (PASMCs). apoptosis‑related proteins analyzed using western...
Abstract Babesia spp. are intraerythrocytic apicomplexans that digest and utilize red blood cells in a similar way to Plasmodium spp., but unlike the latter, not sensitive artemisinin. A comparison of genomes revealed genomes, which smaller than those , lack numerous genes, especially haem synthesis-related found latter. Single-cell sequencing analysis showed different treatment groups microti with expressed pentose phosphate pathway-related, DNA replication-related, antioxidation-related,...