A5108245288- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Vascular anomalies and interventions
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Oil and Gas Production Techniques
- Coronary Artery Anomalies
- COVID-19 Clinical Research Studies
- Drilling and Well Engineering
- Cardiovascular Issues in Pregnancy
- Congenital heart defects research
- Reservoir Engineering and Simulation Methods
- Phonocardiography and Auscultation Techniques
- Cardiovascular and Diving-Related Complications
- Tissue Engineering and Regenerative Medicine
- Metallurgy and Material Forming
- COVID-19 and healthcare impacts
- Metal Forming Simulation Techniques
- SARS-CoV-2 and COVID-19 Research
- Genetic and Kidney Cyst Diseases
- Respiratory viral infections research
- Hydraulic Fracturing and Reservoir Analysis
- RNA modifications and cancer
Shanghai Children's Medical Center
2015-2025
Shanghai Jiao Tong University
2016-2025
Shanghai Children's Hospital
2022
South China University of Technology
2019-2021
Guangdong Academy of Medical Sciences
2016
Guangdong General Hospital
2016
Ideon Innovation (Sweden)
2015
Daqing Oilfield General Hospital
2013-2014
Total anomalous pulmonary venous connection (TAPVC) is a rare form of congenital heart disease. This study describes current surgical treatment strategies and experiences in cohort patients from 2 cardiac centers Shanghai Guangdong China.This retrospective included 768 operated on between 2005 2014. Although most (n=690) underwent conventional repair, sutureless technique was used 10% (n=78) cases. A multilevel mixed-effects parametric survival model competing-risk analysis were to analyze...
Computer-assisted auscultation has become available to assist clinicians with physical examinations detect congenital heart disease (CHD). However, its accuracy and effectiveness remain be evaluated. This study seeks evaluate the of auscultations abnormal sounds an artificial intelligence-assisted (AI-AA) platform we create.Initially, 1397 patients CHD were enrolled in study. The samples their recorded uploaded using a digital stethoscope. By platform, both remote by team experienced...
Studies focused on pregnant women with congenital heart disease (CHD)-associated pulmonary hypertension (PH) are scarce and limited by small sample sizes single-center design. This study sought to describe the pregnancy outcomes in CHD without PH.
Background Recurrent pulmonary vein stenosis (PVS) following surgical repair of total anomalous venous connection is associated with poor prognosis. Preclinical studies have shown that use an angiotensin receptor blocker can attenuate intimal hyperplasia; notwithstanding, its clinical utility uncertain benefit. Methods This single‐center study included patients undergoing in 2020 to 2021. Since August 2020, been considered for valsartan therapy early after operation. Contemporaneous...
The optimal surgical strategies for pulmonary atresia with intact ventricular septum (PAIVS) are still not well established. This study reviewed our 15-year experience in the management of PAIVS. Between July 1999 and June 2014, 170 patients were treated PAIVS heart centre. Based on morphology right ventricle (RV), age approaches, divided into two groups: one-stage surgery group (n = 33) staged 137), which received definitive repair, including biventricular 1.5 repair univentricular...
The present study developed a cardiac extracellular matrix-chitosan-gelatin (cECM-CG) composite scaffold that can be used as tissue-engineered heart patch and investigated its endothelialization potential by incorporating CD34+ endothelial progenitor cells (EPCs). cECM-CG was prepared blending matrix (cECM) with biodegradable chitosan-gelatin (CG). mixture lyophilized using vacuum freeze-drying. EPCs were isolated seeded on the scaffolds, then effect subsequently investigated. Effects of...
Chronic hypoxia, common in neonates, disrupts gut microbiota balance, which is crucial for brain development. This study utilized cyanotic congenital heart disease (CCHD) patients and a neonatal hypoxic rat model to explore the association. Both rats CCHD infants exhibited immaturity, white matter injury (WMI), inflammation, motor/learning deficits. Through 16s rRNA sequencing metabolomic analysis, reduction
Abstract Small RNAs, especially the microRNAs, have been revealed to play great roles in heart development and congenital defects. Several studies shown dysregulated miRNAs ventricular tissues of Tetralogy Fallot (TOF) patients. In present study, we conducted high throughput sequencing obtain global profiling small RNA transcriptome right samples from 10 age -matched TOF These showed dominant composition miRNA mitochondrial associated RNAs. By sRNA cluster identification differential gene...
Abstract Objectives: To study the effects of a self-powered Fontan circulation in both idealized models and patient-specific models. Methods: In silico, conduit with nozzle was introduced from ascending aorta into anastomosis superior vena cava pulmonary artery. Computational fluid dynamics (CFD) simulation applied to calculate fields Three 3-dimentional different offsets were reconstructed by computer-aided design evaluate conduit. Furthermore, validate models, three offsets. Results: The...
Total anomalous pulmonary venous connection (TAPVC) is a rare but mortal congenital heart disease in children and can be repaired by surgical operations. However, some patients may suffer from obstruction (PVO) after surgery with insufficient blood supply, necessitating special follow-up strategy treatment. Therefore, it clinically important yet challenging problem to predict such before surgery. In this paper, we address issue propose computational framework determine the risk factors for...
CNV is a vital pathogenic factor of congenital heart disease (CHD). However, few CNVs have been reported for total anomalous pulmonary venous connection (TAPVC), which rare form CHD. Using case-control study, we identified 15q11.2 deletion associated with TAPVC. We then used TAPVC trio as model to reveal possible molecular basis microdeletion.
Pulmonary vein stenosis (PVS) continues to be a major complication after surgical repair of total anomalous pulmonary venous connection (TAPVC). Recent studies suggest that the morphology confluence and left atrium (LA) is associated with PVS. However, there are limited data on prognostic value integrating quantitative confluence-atrial into risk stratification.
Management of complete atrioventricular (AV) septal defect (CAVSD) with a large ventricular component (>1 cm) remains controversial. The purpose this study was to assess the feasibility one-and-a-half patch technique in repairing lesion. This retrospective review patients undergoing surgical repair CAVSD cm). Of 51 who were identified our database (2005–13), 18 underwent two-patch repair, 12 modified single-patch and 21 one-and-a-half-patch repair. combined tetralogy Fallot (TOF) 3...
Although various surgical techniques have been reported for aortic arch reconstruction proximal and distal transverse (PDTA) hypoplasia, no consensus has reached on a option initial reconstruction. This study was undertaken to review options PDTA hypoplasia in Chinese infants.A retrospective of 121 infants who underwent the arches between 2010 2020 performed. Freedom from recoarctation analyzed using Kaplan-Meier analysis. Univariate multivariable Cox regression analyses were performed...