A5029085468- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Tracheal and airway disorders
- Cardiovascular Issues in Pregnancy
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Cardiomyopathy and Myosin Studies
- Coronary Artery Anomalies
- Vascular anomalies and interventions
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Congenital heart defects research
- Cardiac Imaging and Diagnostics
- Medical Image Segmentation Techniques
- Infective Endocarditis Diagnosis and Management
- Advanced Algorithms and Applications
- Advanced X-ray and CT Imaging
- Cardiac Arrhythmias and Treatments
- Artificial Immune Systems Applications
- Advanced MRI Techniques and Applications
- Cardiovascular and Diving-Related Complications
- Image and Signal Denoising Methods
- Advanced Neural Network Applications
Guangdong Provincial People's Hospital
2007-2025
Guangdong Academy of Medical Sciences
2016-2025
Zhongshan Hospital
2010-2025
Fudan University
2010-2025
Sun Yat-sen University
2010-2025
Southern Medical University
2022-2025
Shanghai Electric (China)
2025
Foton Motors (China)
2025
Sinopec (China)
2025
Zhejiang University of Technology
2024-2025
Total anomalous pulmonary venous connection (TAPVC) is a rare form of congenital heart disease. This study describes current surgical treatment strategies and experiences in cohort patients from 2 cardiac centers Shanghai Guangdong China.This retrospective included 768 operated on between 2005 2014. Although most (n=690) underwent conventional repair, sutureless technique was used 10% (n=78) cases. A multilevel mixed-effects parametric survival model competing-risk analysis were to analyze...
There are 16.5 million newborns in China annually. However, the incidence of congenital heart disease (CHD) has not been evaluated. In 2004, we launched an active province-wide hospital-based CHD registry Guangdong Province southern China. this study, examined and its subtypes from 2004 to 2012 compared our findings literature. Our results indicate there is increasing trend incidence. The increase occurred mainly for single lesion most common (e.g., ventricular or atrial septal defect,...
Umbilical cord mesenchymal stem cells (UCMSCs) transplantation has been proposed as a promising treatment modality for myocardial infarction (MI), but the low retention rate remains considerable challenge. Injectable natural polymer hydrogels with conductivity ability are highly desirable cell delivery vehicles to repair infarct myocardium and restore cardiac function. In this work, we developed hydrogel system based on gelatin methacrylate (GelMA) oxidized dextran (ODEX) MI. And dopamine...
Carvedilol, a nonselective β-adrenoreceptor antagonist, protects against myocardial injury induced by acute myocardium infarction (AMI). The mechanisms underlying the anti-fibrotic effects of carvedilol are unknown. Recent studies have revealed critical role microRNAs (miRNAs) in variety cardiovascular diseases. This study investigated whether miR-29b is involved cardioprotective effect AMI-induced fibrosis. Male SD rats were randomized into several groups: sham surgery control, left...
Prenatal exposure to toxic trace elements, including heavy metals, is an important public health concern. Few studies have assessed if individual and multiple elements simultaneously affect cardiac development. The current study evaluated the association between maternal blood lead (Pb), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), selenium (Se) levels congenital heart defects (CHDs) in offspring. This hospital-based case-control included 112 case 107 control infants. Maternal...
Constructing three-dimensional (3D) aligned nanofiber scaffolds is significant for the development of cardiac tissue engineering, which promising in field drug discovery and disease mechanism study. However, current scaffold preparation strategy, mainly includes manual assembly hybrid 3D printing, faces challenge integrated fabrication morphology-controllable nanofibers due to its cross-scale structural feature. In this research, a trench-guided electrospinning (ES) strategy was proposed...
Multi-modal sentiment analysis (MSA) aims to regress or classify the overall of utterances through acoustic, visual, and textual cues. However, most existing efforts have focused on developing expressive ability neural networks learn representation multi-modal information within a single utterance, without considering global co-occurrence characteristics dataset. To alleviate above issue, in this paper, we propose novel hierarchical graph contrastive learning framework for MSA, aiming...
The embryonic process of forming a complex structure such as the heart remains poorly understood. Here, we show that Six2 marks dynamic subset second field progenitors. Six2-positive (Six2+) progenitors are rapidly recruited and assigned, their descendants allocated successively to regions from right ventricle (RV) pulmonary trunk. Global ablation Six2+ resulted in RV hypoplasia atresia. An early stage-specific small did not cause any apparent structural defect at birth but rather...
Background Maternal folic acid supplementation (FAS) reduces the risk of neural tube defects in offspring. However, its effect on congenital heart disease (CHDs), especially severe ones remains uncertain. This study aimed to assess individual and joint first-trimester maternal FAS multivitamin use CHDs Methods Results is a case-control including 8379 confirmed CHD cases 6918 controls from 40 healthcare centers 21 cities Guangdong Province, China. Adjusted odds ratios (aORs) between (overall...
The present study aimed to prospectively evaluate the role of metagenomic next-generation sequencing (mNGS) in etiological diagnosis patients with perioperative infective endocarditis (IE).From May 1st, 2019 December 31st, 2020, a total 99 IE were enrolled according modified Duke criteria, etiological, and pathological results. 11 non-IE undergoing heart valve surgery same period selected as control group. A blood culture test was performed immediately after admission, valves harvested...
Alternative artificial vessels with tissue-matching mechanical and biological performance have been continuously taking great attention in bioengineering. However, it is challenging to take into account both properties formulating a hydrogel material. In the current study, composite ink based on geltain-methacryloyl (GelMA) sodium alginate (SA) was prepared by two-step polymerization process, its fast shaping realized stabilizing fraction calcium ion bath as well photo-crosslinking of GelMA....
Objective: Congenital heart diseases (CHDs) are associated with an extremely heavy global disease burden as the most common category of birth defects. Genetic and environmental factors have been identified risk CHDs previously. However, high volume clinical indicators never considered when predicting CHDs. This study aimed to predict occurrence by considering thousands variables from self-reported questionnaires routinely collected laboratory data using machine learning algorithms. Methods:...
Highlights•iPS-DCregs keep in stable immature stage that makes them a powerful cellular vaccine•Donor-type iPS-DCregs lead to permanent acceptance of allogeneic cardiac grafts•iPS-DCregs reduce CTL and downregulate proinflammatory cytokine•iPS-DCregs enhance Tregs transmigration capability TGF-β1-dependent mannerSummaryRegulatory dendritic cell (DCregs)-based immunotherapy is potential therapeutic tool for transplant rejection. We generated DCregs from murine induced pluripotent stem cells...
Congenital heart defects (CHDs) are a major cause of death in infancy and childhood. Major risk factors for most CHDs, particularly those resulting from the combination environmental exposures with social determinants behaviors, still unknown. This study evaluated main effect maternal tobacco smoke (ETS), its interaction social-demographics on CHDs China. A population-based, matched case-control 9452 live-born infants stillborn fetuses was conducted using Guangdong Registry Heart Disease...