A5100354006- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Mesenchymal stem cell research
- Connective tissue disorders research
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Migraine and Headache Studies
- Advanced Computational Techniques and Applications
- Extracellular vesicles in disease
- Transcranial Magnetic Stimulation Studies
- Trigeminal Neuralgia and Treatments
- Bacterial Identification and Susceptibility Testing
- Cardiac Arrest and Resuscitation
- Text and Document Classification Technologies
- Natural Language Processing Techniques
- Gut microbiota and health
- Topic Modeling
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Antibiotic Resistance in Bacteria
- Neonatal Health and Biochemistry
- Long-Term Effects of COVID-19
Guangdong Academy of Medical Sciences
2015-2025
Guangdong Provincial People's Hospital
2016-2025
Southern Medical University
2020-2025
Tongji Hospital
2024-2025
South China University of Technology
2017-2025
Huazhong University of Science and Technology
2023-2025
Guangzhou University of Chinese Medicine
2025
National University of Defense Technology
2014-2025
Shantou University
2017-2024
Shantou University Medical College
2017-2024
In order to respond correctly a free form factual question given large collection of texts, one needs understand the level that allows determining some constraints imposes on possible answer. These may include semantic classification sought after answer and even suggest using different strategies when looking for verifying candidate answer.This paper presents machine learning approach classification. We learn hierarchical classifier is guided by layered hierarchy types, eventually classifies...
We previously identified an immunomodulatory role of human induced pluripotent stem cell (iPSC)-derived mesenchymal cells (MSCs) in asthmatic inflammation. Mitochondrial transfer from bone marrow MSCs to epithelial can result the attenuation acute lung injury mice. However, effects mitochondrial iPSC-MSCs asthma and mechanisms underlying these are unclear. found that iPSC-MSC transplantation significantly reduced T helper 2 cytokines, attenuated dysfunction cells, alleviated inflammation...
Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the two remains elusive.Two independent case-control studies were conducted involving 307 patients 399 healthy controls in geographically distinct areas China. Our data revealed that subjects...
Homologous recombination deficiency (HRD) is prevalent in cancer, sensitizing tumor cells to poly (ADP-ribose) polymerase (PARP) inhibition. However, the impact of HRD and related therapies on microenvironment (TME) remains elusive. Our study generates single-cell gene expression T cell receptor profiles, along with validatory multimodal datasets from >100 high-grade serous ovarian cancer (HGSOC) samples, primarily a phase II clinical trial (NCT04507841). Neoadjuvant monotherapy PARP...
Abstract Aging impairs the functions of human mesenchymal stem cells (MSCs), thereby severely reducing their beneficial effects on myocardial infarction (MI). MicroRNAs (miRNAs) play crucial roles in regulating senescence MSCs; however, underlying mechanisms remain unclear. Here, we investigated significance miR‐155‐5p MSC and whether inhibition could rejuvenate aged MSCs (AMSCs) to enhance therapeutic efficacy for MI. Young (YMSCs) AMSCs were isolated from young donors, respectively. The...
Mesenchymal stem cell- (MSC-) based therapy is a novel strategy in regenerative medicine. The functional and capacities of MSCs decline with senescence. Nonetheless, the potential mechanisms that underlie their senescence are not fully understood. This study was aimed at exploring fibroblast growth factor 21 (FGF21) regulation MSC determined by senescence-associated β -galactosidase (SA- -gal) staining. morphology level mitochondrial reactive oxygen species (ROS) were assessed MitoTracker...
Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy to treat many degenerative diseases. Accumulating evidence shows that the function of MSCs declines with age, thus limiting their regenerative capacity. Nonetheless, underlying mechanisms control MSC ageing are not well understood. We show compared bone marrow-MSCs (BM-MSCs) isolated from young and aged samples, NADH dehydrogenase (ubiquinone) iron-sulfur protein 6 (Ndufs6) is depressed in MSCs. Similar Ndufs6 knockout...
Application of mesenchymal stem cell-derived exosomes (MSC-EXO) has emerged as a novel therapeutic strategy for myocardial infarction (MI). Our previous study showed that pretreatment with hemin, potent heme oxygenase-1 (HO-1) inducer, enhanced the cardioprotective effects MSCs in mouse model MI. This aimed to investigate EXO derived from hemin-pretreated (Hemin-MSC-EXO) MI and explore potential mechanisms.MSC-EXO Hemin-MSC-EXO were collected characterized. MSC-EXO intramuscularly injected...
Abstract Doxorubicin (DOX) is a chemotherapeutic agent widely used for tumor treatment. Nonetheless its clinical application heavily limited by cardiotoxicity. There accumulated evidence that transplantation of mesenchymal stem cell-derived exosomes (MSC-EXOs) can protect against Dox-induced cardiomyopathy (DIC). This study aimed to examine the cardioprotective effects EXOs isolated from human induced pluripotent MSCs (iPSC-MSCs) DIC and explore potential mechanisms. were cultural...
Ovarian cancer (OC) is prone to peritoneum or omentum dissemination, thus giving rise the formidable challenge of unresectable surgery and a dismal survival rate. Although niraparib holds pivotal role in maintenance treatment OC, its effect on suppressing metastases during primary intervention remains enigmatic. Recently, we initiated prospective clinical study (NCT04507841) order evaluate therapeutic efficacy neoadjuvant monotherapy for advanced OC with homologous recombination deficiency....
Abstract Adult mesenchymal stem cells (MSCs) are immunoprivileged due to the low expression of major histocompatibility complex (MHC) II molecules. However, MHC molecules in human-induced pluripotent (iPSCs)-derived MSCs has not been investigated. Here, we examined human leukocyte antigen (HLA) derived from iPSCs, fetuses, and adult bone marrow (BM) after stimulation with interferon-γ (IFN-γ), compared their repair efficacy, cell retention, inflammation, HLA immune humanized NOD Scid gamma...
Abstract Senescence of vascular smooth muscle cells (VSMCs) contributes to the formation abdominal aortic aneurysm (AAA). Although mesenchymal stem cell exosomes (MSC-EXO) have been confirmed restrict development AAA, their biological activity depends largely on physiological state MSCs. This study aimed compare effects adipose-derived MSC-EXO from healthy donors (HMEXO) and AAA patients (AMEXO) senescence VSMCs in explore underlying mechanisms. An ApoE-/- mouse model was used investigate...
In addition to their established action of synthetic lethality in tumor cells, poly(ADP-ribose) polymerase inhibitors (PARPis) also orchestrate immune microenvironment (TIME) that contributes suppressing growth. However, it remains not fully understood whether and how PARPis trigger tumor-targeting responses.
The goal of a text classification system is to determine whether given document belongs which the predefined categories. An optimal SVM algorithm for via multiple strategies proposed in this paper. experimental results indicate that yields much better performance than other conventional algorithms
Idiopathic pulmonary fibrosis (IPF) is an age-related disease with no cure. Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy for IPF treatment. Nevertheless, MSCs derived from patients (IPF-MSCs) become senescent, thereby reducing their beneficial effects in IPF. MicroRNAs (miRNAs) mediate the senescence of MSCs, but underlying mechanisms are not fully understood. We investigated by which miR-199a-5p regulates IPF-MSC and whether its inhibition could rejuvenate...
The present study aimed to prospectively evaluate the role of metagenomic next-generation sequencing (mNGS) in etiological diagnosis patients with perioperative infective endocarditis (IE).From May 1st, 2019 December 31st, 2020, a total 99 IE were enrolled according modified Duke criteria, etiological, and pathological results. 11 non-IE undergoing heart valve surgery same period selected as control group. A blood culture test was performed immediately after admission, valves harvested...
Vaginal flora plays a vital role in human papillomavirus (HPV) infection and progression to cancer. To reveal of the vaginal HPV persistence clearance, 90 patients with 45 healthy individuals were enrolled this study their analyzed. Women treated Lactobacillus environment as supplement interferon therapy. Our results indicated that high risk (Hr-HPV) 16/18 had significantly higher alpha diversity compared control ( p < 0.01), while there was no significant difference between...
Arterial aneurysms are life-threatening but usually asymptomatic before requiring hospitalization. Oculomics of retinal vascular features (RVFs) extracted from fundus images can reflect systemic properties and therefore were hypothesized to provide valuable information on detecting the risk aneurysms. By integrating oculomics with genomics, this study aimed (i) identify predictive RVFs as imaging biomarkers for (ii) evaluate value these in supporting early detection context predictive,...
The association between emergency department (ED) length of stay (EDLOS) with in-hospital mortality (IHM) in older patients remains unclear. This retrospective study aims to delineate the relationship EDLOS and IHM elderly patients. From ED (n = 383,586) who visited an urban academic tertiary care medical center from January 2010 December 2016, 78,478 (age ≥60 years) were identified stratified into three age subgroups: 60-74 (early elderly), 75-89 (late ≥90 years (longevous elderly). We...
Abstract The cardiac protection of mesenchymal stem cell (MSC) transplantation for myocardial infarction (MI) is largely hampered by low survival. Haem oxygenase 1 (HO‐1) plays a critical role in regulation survival under many stress conditions. This study aimed to investigate whether pre‐treatment with haemin, potent HO‐1 inducer, would promote the MSCs serum deprivation and hypoxia (SD/H) enhance cardioprotective effects MI. Bone marrow (BM)‐MSCs were pretreated or without haemin then...