A5019177183- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Infectious Aortic and Vascular Conditions
- Cardiac Valve Diseases and Treatments
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Angiogenesis and VEGF in Cancer
- Renal and Vascular Pathologies
- Coronary Interventions and Diagnostics
- Connective tissue disorders research
- Abdominal vascular conditions and treatments
- Congenital Heart Disease Studies
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- Cardiac Structural Anomalies and Repair
- Circular RNAs in diseases
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations Diagnosis and Treatment
- Peripheral Artery Disease Management
- Central Venous Catheters and Hemodialysis
- Cancer-related molecular mechanisms research
- Vascular anomalies and interventions
- Cardiac and Coronary Surgery Techniques
- Protein Degradation and Inhibitors
- Cholangiocarcinoma and Gallbladder Cancer Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Second Xiangya Hospital of Central South University
2016-2025
Central South University
2016-2025
Fuwai Yunnan Cardiovascular Hospital
2022-2025
Tongji Hospital
2018-2025
Huazhong University of Science and Technology
2014-2025
Kunming Medical University
2025
Zhengzhou University
2025
University of Nottingham Ningbo China
2020-2025
Peking Union Medical College Hospital
2014-2024
Several studies have suggested that long intergenic noncoding RNAs are involved in the progression of diabetic nephropathy (DN). However, exact role and regulatory mechanism RNA (lncRNA) NR_038323 (DN) remain largely unclear. In present study, we found lncRNA overexpression ameliorated high glucose (HG)-induced expression levels collagen I, IV, fibronectin, whereas knockdown exerted opposite effects. Moreover, results bioinformatic prediction, luciferase assay, fluorescence situ...
Abstract Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition characterized by medial layer degeneration of the thoracic aorta. A thorough understanding regulator changes during pathogenesis essential for medical therapy development. To delineate cellular molecular development TAAD, we performed single-cell RNA sequencing cells from β-aminopropionitrile-induced TAAD mouse models at three time points that spanned early to advanced stages disease. Comparative analyses...
Background: Numerous studies have attempted to apply artificial intelligence (AI) in the dermatological field, mainly on classification and segmentation of various dermatoses. However, researches under real clinical settings are scarce. Objectives: This study was aimed construct a novel framework based deep learning trained by dataset that represented environment tertiary class hospital China, for better adaptation AI application practice among Asian patients. Methods: Our composed 13,603...
Timely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC to mice similarly impacted time post hepatectomy. However, oral gavage B. longum improved repair these mice. In clinical trial...
A diameter of 50 or 55 mm is the primary clinical criterion for assessing abdominal aortic aneurysm (AAA) rupture risk. However, although larger diameters may induce higher risk, not all AAAs exceeding intervention threshold will rupture, highlighting need indicators besides to help prediction and treatment AAA ≥ mm. The study aims combine computation, experiment, statistics establish models explore optimal predictors with different by anatomical hemodynamic characteristics. Through...
To summarize a single-center experience using the single/double chimney technique in association with thoracic endovascular aortic repairs (TEVAR) for arch pathologies.From November 2007 to March 2016, 122 patients (mean age 50.4±12.7 years, range 29-80; 92 men) pathologies underwent TEVAR combined single (n=101) or double (n=21) grafts reconstruct supra-aortic branches: 21 innominate arteries, 114 left common carotid and 8 subclavian arteries (LSA). Pathologies included type B dissection...
Kaimin Zhou, Chang Shu, Binyang Li, Jey Han Lau. Proceedings of the 2019 Conference North American Chapter Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long and Short Papers). 2019.
Despite DNA methylation occurred in acute kidney injury (AKI), how it influenced progression of AKI remains unclear. Methyl-CpG-binding domain protein 2 (MBD2), a readers methylation, was used to analyze the impact on vancomycin (VAN)-induced AKI. Here, cultured human tubular epithelial cells (HK-2), we show that knockdown MBD2 by siRNA attenuated VAN-induced apoptosis, caspase activity, and expression BAX cleaved 3. Interestingly, associated with suppression miR-301a-5p. Mechanistic studies...
The prediction of mortality for septic acute kidney injury (AKI) has been assessed by a number potential biomarkers, including long noncoding RNAs (lncRNAs). However, the validation lncRNAs as particularly early stages AKI, is still warranted. Our results indicate that lncRNA TCONS_00016233 upregulated in plasma sepsis-associated non-AKI and AKI patients, but higher cutoff threshold (9.5 × 105, copy number) provided sensitivity 71.9% specificity 89.6% detection AKI. was highly correlated...
Limited biomarkers have been identified as prognostic predictors for stage III colon cancer. To combat this shortfall, we developed a computer-aided approach which combing convolutional neural network with machine classifier to predict the prognosis of cancer from routinely haematoxylin and eosin (H&E) stained tissue slides. We trained model by using 101 cancers West China Hospital (WCH). The predictive effectivity was validated 67 WCH 47 Cancer Genome Atlas Colon Adenocarcinoma database....
Revascularization of the supra-aortic major branches in thoracic endovascular aortic repair (TEVAR) is challenging owing to complex anatomic configuration arch pathologies. This study aims evaluate feasibility, effectiveness, and safety three techniques-chimney, fenestrated, in-situ fenestration-for patients with pathologies.A retrospective analysis was performed involving 234 lesions, who underwent TEVAR adaptations technique (chimney, or fenestration) between January 2016 December 2017.One...
Abstract The aortic dissection (AD) is a life-threatening disease. transcatheter endovascular repair (EVAR) affords minimally invasive technique to save the lives of these critical patients, and an appropriate stent-graft gets be key medical device during EVAR procedure. Herein, we report trilayer corresponding delivery system used for treatment AD made nitinol stents with asymmetric Z-wave design two expanded polytetrafluoroethylene (ePTFE) membranes. Each inner outer surfaces was covered...
Aim: We hypothesized that delivery of mesenchymal stem cells (MSCs) in a biomimetic collagen scaffold improves wound healing diabetic mouse model. Materials & methods: Rolled scaffolds containing MSCs were implanted or applied topically to C57BL/6 mice with excisional wounds. Results: hypoxic, inducing MSC synthesis and secretion VEGF. Diabetic wounds treated rolled showed increased compared controls. Histologic examination cellular proliferation, VEGF expression capillary density, numbers...