To investigate the diagnostic efficiency and prognostic value of 68Ga-Pentixafor PET/CT in comparison with adrenal vein sampling (AVS) for functional lateralization primary aldosteronism (PA). Histology long-term clinical follow-up normally serve as gold standard such diagnosis. We prospectively recruited 26 patients diagnosed PA. All underwent AVS. Postsurgical biochemical outcomes unilateral (UPA), by or AVS, were assessed applying standardized Primary Aldosteronism Surgical Outcome (PASO)...

The abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs and long ncRNAs, often contribute to the development cancers. miR-200c functions a tumour suppressor that impacts growth bladder cancer cells epithelial-to-mesenchymal transition (EMT). LncRNA X inactive specific transcript (XIST) is highly expressed in tissues, promotes progression might act an miRNA molecular sponge. This study aimed examine relationship between lncRNA XIST assess their regulation stemness properties...

The prediction of mortality for septic acute kidney injury (AKI) has been assessed by a number potential biomarkers, including long noncoding RNAs (lncRNAs). However, the validation lncRNAs as particularly early stages AKI, is still warranted. Our results indicate that lncRNA TCONS_00016233 upregulated in plasma sepsis-associated non-AKI and AKI patients, but higher cutoff threshold (9.5 × 105, copy number) provided sensitivity 71.9% specificity 89.6% detection AKI. was highly correlated...

Abstract Bladder cancer (BCa) is an aggressive malignancy because of its distant metastasis and high recurrence rate. Circular RNAs (circRNAs) exert critical regulatory functions in progression. However, the expression patterns roles circRNAs BCa have not been well investigated. In this study, we first screened circRNA profiles using a microarray paired normal tissues, circST6GALNAC6 was confirmed by qRT-PCR fluorescence situ hybridization (FISH). MTT, colony formation Transwell assays were...

DNA methylation plays a pivotal role in the progression of renal fibrosis. Methyl-CpG-binding domain protein 2 (MBD2), reader methylation, is involved development acute kidney injury (AKI) caused by vancomycin. However, and mechanism action MBD2 remain unclear. In this study, mediated extracellular matrix (ECM) production induced TGF-β1 Boston University mouse proximal tubule (BUMPT) cells，and upregulated expression EGR1 to promote ECM murine embryonic NIH 3T3 fibroblasts. ChIP analysis...

The thalamus has been reported to be associated with pain modulation and processing. However, the functional changes that occur in of vestibular migraine (VM) patients remain unknown.In total, 28 VM healthy controls who were matched for age sex underwent resting-state magnetic resonance imaging. They also responded standardized questionnaires aimed at assessing clinical features vertigo. Differences amplitude low-frequency fluctuation (ALFF) analyzed brain regions altered ALFF two groups...

Background/Aims: Emerging studies have shown that the neutrophil-lymphocyte ratio (NLR) is a potential predictor in various tumors. Our study was conducted to assess prognostic value of pretreatment NLR bladder cancer and metastatic or unresectable urothelial carcinoma (mUC uUC) patients up July 2017. The correlation between pathological characteristics also evaluated patients. Methods: hazard (HR) odds (OR) with 95% confidence interval (CI) were extracted calculated from included for...

Abstract Recent studies reported that Methyl-CpG–binding domain protein 2 (MBD2) promoted M2 macrophages accumulation to increase bleomycin-induced pulmonary fibrosis. However, the role and mechanism of action MBD2 in differentiation renal fibrosis remain largely unknown. In current study, not only resting M0 polarized macrophages, but also induced them M1 transition macrophages. ChIP analysis demonstrated physically interacted with promoter region CpG islands G0S2 genes, then activated...

In this study, we investigated the role of circular RNA_30032 (circRNA_30032) in renal fibrosis and underlying mechanisms. The study was carried out using TGF-β1-induced BUMPT cells unilateral ureteral obstruction (UUO)-induced mice, respectively, as vitro vivo models. CircRNA_30032 expression significantly increased by 9.15- 16.6-fold on days 3 7, tissues UUO model mice. TGF-β1-treated cells, circRNA_30032 induced activation p38 mitogen-activated protein kinase signaling pathway....

Abstract Objective We aimed to reveal the role of structural and functional alterations cingulate gyrus in early cognitive impairment Type 2 diabetes mellitus (T2DM) patients. Methods Fifty‐six T2DM patients 60 healthy controls (HCs) underwent a neuropsychological assessment sagittal three‐dimensional T1‐weighted resting‐state MRI. Differences cortical thickness cortex connectivity (FC) nine subregions whole brain were compared between HCs. Correlation analysis was performed FC participants'...

This paper presents a novel approach for simulating acoustic-shell interaction, specifically focusing on seabed reflection effects. The interaction between acoustic waves and shell vibration is crucial in various engineering applications, particularly underwater acoustics ocean engineering. study employs the finite element method (FEM) with Kirchhoff-Love elements to numerically analyze thin-shell vibrations. boundary (BEM) applied simulate exterior fields reflections, using half-space...

To explore the glymphatic dysfunction in relapsing-remitting multiple sclerosis (RRMS) and its potential associations with brain structural damage, clinical disability, cognitive impairment (Co-I). The study involved 70 patients RRMS 44 healthy controls. Neurological MRI assessments were performed, performance was assessed via Brief Repeatable Battery of Neuropsychological Tests (BRB-N). assess function, we calculated choroid plexus volume (CPV) diffusion tensor imaging along perivascular...

Background : Increasing evidence suggests that the temporal and parietal lobes are associated with multisensory integration vestibular migraine. However, lobe structural functional connectivity (FC) changes related to migraine need be further investigated. Methods Twenty-five patients (VM) 27 age- sex- matched healthy controls participated in this study. Participants completed standardized questionnaires assessing vertigo-related clinical features. Cerebral cortex characteristics [i.e.,...

Abstract Circular RNAs (circRNAs) are involved in the pathogenesis of certain renal diseases, however, function and mechanism them fibrosis remains largely unknown. In present study, RNA expression data unilateral ureteral obstruction (UUO) kidneys was obtained from our previous circRNA Microarray public Gene Expression Omnibus datasets to construct a ceRNA network. The effects target as long homologous human on examined vitro vivo. ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...

Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM), and early cognitive dysfunction may be associated with abnormal changes in the cerebral cortex. This retrospective study aimed to investigate cortical thickness-based structural topological network T2DM patients without mild (MCI). Fifty-six 59 healthy controls underwent neuropsychological assessments sagittal 3-dimensional T1-weighted magnetic resonance imaging. Then, we combined graph theoretical analysis...

Background This study aimed to identify disruptions in white matter integrity type 2 diabetes mellitus (T2DM) patients by utilizing the tract (WMTI) model, which describes compartment-specific diffusivities intra- and extra-axonal spaces, investigate relationship between WMTI metrics clinical cognitive measurements. Methods A total of 73 with T2DM 57 healthy controls (HCs) matched for age, sex, education level were enrolled underwent diffusional kurtosis imaging assessments. Tract-based...

Background Atherosclerosis (AS) is the main cause of macrovascular disease. Previous studies have found sex differences in prevalence type 2 diabetes mellitus (T2DM) and its associated disease outcomes. However, relationship between differences, T2DM, AS not fully understood. This study attempts to explore possible associations sex, treatment, burden intracranial atherosclerosis (ICAS) patients with T2DM who experienced an acute ischemic cerebrovascular Methods We focused on stroke or...

Cerebellar dysfunction is a key aspect of schizophrenia, with the cerebello-thalamo-cortical (CTC) hyperconnectivity serving as neural signature. Abnormalities in gamma-aminobutyric acid (GABA) and glutamate + glutamine (Glx) levels also contribute to this pathology. Transcranial magnetic stimulation (TMS) applied cerebellum shows potential alleviating schizophrenia symptoms, possibly by modulating functional connectivity or neurotransmitter levels. This study aims explore immediate effects...

Purpose We aimed to investigate the differences in plaque characteristics and hemodynamics patients with ischemic stroke transient attack (TIA), comparing diagnostic abilities of high-resolution magnetic resonance imaging (HRMRI) arterial spin labeling (ASL) for stroke. Methods This retrospective analysis included who underwent HRMRI ASL between October 2020 December 2023. compared clinical risk factors, vascular characteristics, presence transit artifacts (ATAs) at post-labeling delays...

Abstract Background CXCR4 PET/CT imaging has emerged as a tool for diagnosis and subtyping of primary aldosteronism (PA). But its prognostic value postoperative blood pressure recovery not been fully discussed. Results The lesional SUVmax to the contralateral adrenal tissue SUVmean ratio (LCR) was identified an independent predictor clinical success at both 3-month 6-month assessments. AUC LCR 0.894 0.832 6-month. Patients were divided into high low groups according optimal cut-off 3.240....

Sex is a crucial determinant in the clinical manifestations of diseases. However, previous studies have not clarified whether altered brain morphology shows sex-specific patterns patients with Parkinson's disease (PD) or without possible rapid eye movement sleep behavior disorder (RBD). This study aimed to investigate differences morphological changes among different subgroups PD. High-resolution T1-weighted magnetic resonance imaging and scale data were collected from 278 participants...