A5101800263- Chronic Kidney Disease and Diabetes
- Circular RNAs in diseases
- Prostate Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Ferroptosis and cancer prognosis
- Viral gastroenteritis research and epidemiology
- Advanced Glycation End Products research
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Renal cell carcinoma treatment
- Mitochondrial Function and Pathology
- Urinary Bladder and Prostate Research
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Renal Diseases and Glomerulopathies
- Hepatitis Viruses Studies and Epidemiology
- Epigenetics and DNA Methylation
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
Second Xiangya Hospital of Central South University
2006-2025
Central South University
2006-2025
Guangxi Academy of Fishery Sciences
2023
BGI Group (China)
2023
BGI Research
2023
University of Chinese Academy of Sciences
2023
University of Electronic Science and Technology of China
2021
Sichuan Cancer Hospital
2021
Xiamen University
2018-2019
Southern Medical University
2019
Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN). However, the role and regulation proximal tubular DsbA-L for tubulointerstitial fibrosis (TIF) remains unclear. In current study, we found a tubules-specific knockout mouse (PT-DsbA-L-KO) attenuated UUO-induced TIF, cell apoptosis inflammation. Mechanistically, interacted with Hsp90 mitochondria BUMPT cells which activated...
The prediction of mortality for septic acute kidney injury (AKI) has been assessed by a number potential biomarkers, including long noncoding RNAs (lncRNAs). However, the validation lncRNAs as particularly early stages AKI, is still warranted. Our results indicate that lncRNA TCONS_00016233 upregulated in plasma sepsis-associated non-AKI and AKI patients, but higher cutoff threshold (9.5 × 105, copy number) provided sensitivity 71.9% specificity 89.6% detection AKI. was highly correlated...
The pathogenesis of acute kidney injury (AKI) is still not fully understood, and effective interventions are lacking. Here, we explored whether methyltransferase 3 (METTL3) was involved in the progression AKI via regulation cell death. We reported that PT(proximal tubule)-METTL3-knockout (KO) noticeably suppressed ischemic-induced inhibition renal apoptosis. Furthermore, also found expression mmu-long non-coding RNA (lncRNA) 121686 upregulated antimycin-treated Boston University mouse...
Recent studies suggest that paclitaxel, an anticancer agent, may modulate the injury and inflammatory responses in normal tissues. However, underlying mechanism is not fully understood. Here we have examined effect of paclitaxel on lipopolysaccharide (LPS)–induced acute kidney (AKI) mice further studied mechanism. At relatively low doses, protected against LPS-induced AKI improved animal survival. The beneficial effects were accompanied by downregulation tumor necrosis factor-α,...
DNA methylation plays a pivotal role in the progression of renal fibrosis. Methyl-CpG-binding domain protein 2 (MBD2), reader methylation, is involved development acute kidney injury (AKI) caused by vancomycin. However, and mechanism action MBD2 remain unclear. In this study, mediated extracellular matrix (ECM) production induced TGF-β1 Boston University mouse proximal tubule (BUMPT) cells，and upregulated expression EGR1 to promote ECM murine embryonic NIH 3T3 fibroblasts. ChIP analysis...
Abstract Previous studies reported that RAGE participated in the process of kidney fibrosis, but function and regulation pathway proximal tubular cells this remains unclear. Here, we found expression was increased by TGF-β1 treatment unilateral ureteral obstruction (UUO). Knock down ameliorated renal fibrosis treatment, vimentin, Collagen I&III, fibronectin are decreased. Mechanistically, mediated TGF-β1-induced phosphorylation Stat3 directly upregulated Atg7 to increase level autophagy,...
Abstract Recent studies reported that Methyl-CpG–binding domain protein 2 (MBD2) promoted M2 macrophages accumulation to increase bleomycin-induced pulmonary fibrosis. However, the role and mechanism of action MBD2 in differentiation renal fibrosis remain largely unknown. In current study, not only resting M0 polarized macrophages, but also induced them M1 transition macrophages. ChIP analysis demonstrated physically interacted with promoter region CpG islands G0S2 genes, then activated...
The pathogenesis of Diabetic kidney disease(DKD) involves pathological changes in both tubulo-interstitium and the glomerulus. Surprisingly, tubulo-interstitial fibrosis (TIF), does not develop significantly until late stage DKD. Here, it is demonstrated that PR domain-containing 16 (PRDM16) a key to low level TIF In experiments, PRDM16 upregulated high glucose-treated renal tubular cells, DKD mouse kidneys, biopsy human patients via activation NF-κB signal pathway. High glucose-induced...
In this study, we investigated the role of circular RNA_30032 (circRNA_30032) in renal fibrosis and underlying mechanisms. The study was carried out using TGF-β1-induced BUMPT cells unilateral ureteral obstruction (UUO)-induced mice, respectively, as vitro vivo models. CircRNA_30032 expression significantly increased by 9.15- 16.6-fold on days 3 7, tissues UUO model mice. TGF-β1-treated cells, circRNA_30032 induced activation p38 mitogen-activated protein kinase signaling pathway....
Metformin has shown great potential for anti-tumor therapy according to laboratory results, but there is currently no consensus on the role it playing in pathogenesis of urogenital malignancies. Initially, a systematic review was conducted clinical research examining association between use metformin and incidence prognosis prevalent Then, retrospective analysis participants NHANES performed strengthen study. Given distinct methodological advantages Mendelian randomization (MR) design,...
Abstract Circular RNAs (circRNAs) are involved in the pathogenesis of certain renal diseases, however, function and mechanism them fibrosis remains largely unknown. In present study, RNA expression data unilateral ureteral obstruction (UUO) kidneys was obtained from our previous circRNA Microarray public Gene Expression Omnibus datasets to construct a ceRNA network. The effects target as long homologous human on examined vitro vivo. ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...
To provide a scientific basis for the prevention and treatment of cervical cancer (CC), we investigated distribution characteristics genotypes human papillomavirus (HPV) prevalence multiple HPV infections in women different ages seeking management abnormal cytology Foshan City. Screening 21 was carried out 9945 females results using rapid flow-through hybridization nucleic acid molecules. The overall prevalence, genotype age-specific were examined. Our indicate that overall, high-risk,...
Acute kidney injury (AKI) presents as a condition marked by sudden and rapid decrease in function over short timeframe, resulting from diverse causes. As transcription factor, PR domain-containing 16 (PRDM16), has recently been implicated brown fat biogenesis heart diseases. Our recent works indicated that PRDM16 could suppress the occurrence of renal interstitial fibrosis diabetic disorder. Nonetheless, effect regulatory mechanism AKI remain elusive. study demonstrated inhibited apoptosis...
Abstract Our recent investigation has indicated that the global deletion of MBD2 can mitigate progression AKI induced by VAN. Nevertheless, role and regulatory mechanisms proximal tubular in this pathophysiological process have yet to be elucidated. preceding revealed autophagy played a crucial advancing Consequently, we postulated present tubule could upregulate autophagic expedite onset AKI. In study, found for first time mediated production Through utilization miRNA chip analysis,...
Abstract Cell‐cell interaction is one of the major modalities for transmitting information between cells and activating effects functional cells. However, construction high‐throughput analysis technologies from cell omics focusing on impact interactions targets has been relatively unexplored. Here, they propose a droplet‐based microfluidic platform cell‐cell sequencing (c‐c‐seq) screening in vitro to address this challenge. A class interacting pre‐labeled using molecular tags, additional...
Background Previous surgical strategy of transperitoneal laparoscopic partial nephrectomy (TLPN) and retroperitoneal (RLPN) for treatment renal cell carcinoma (RCC) mainly depend on surgeons’ preference. The aim this study was to evaluate whether performing TLPN anterior tumors RLPN posterior is a more beneficial strategy. Method 214 patients underwent or at our center were retrospectively collected 1:1 matched approach, tumor complexity as well operator. Baseline characteristics...