A5100451397- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Gastrointestinal Tumor Research and Treatment
- Urologic and reproductive health conditions
- Acute Ischemic Stroke Management
- Helicobacter pylori-related gastroenterology studies
- Renal and related cancers
- Circular RNAs in diseases
- Minimally Invasive Surgical Techniques
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Lung Cancer Treatments and Mutations
- S100 Proteins and Annexins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Protease and Inhibitor Mechanisms
Central South University
2014-2025
Second Xiangya Hospital of Central South University
2015-2025
Zhengzhou University
2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2017-2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sichuan University
2024
Henan Cancer Hospital
2024
Chinese Academy of Sciences
2024
Ruijin Hospital
2018-2023
Abstract Neoadjuvant chemotherapy with docetaxel, oxaliplatin, fluorouracil, and leucovorin (FLOT regimen) has shown promising results in terms of pathological response survival rate patients locally advanced resectable gastric cancer (LAGC). However, tegafur gimeracil oteracil potassium capsule (S-1) plus oxaliplatin (SOX is the preferred regimen Eastern countries. Here, we conduct an open label, two-arm, phase II randomized interventional clinical trial (Dragon III; ClinicalTrials.gov:...
Clear cell renal carcinoma (ccRCC) is the most common subtype of and has highest mortality rate.For metastatic RCC, systemic drug therapy important method in addition to surgical tumor reduction.In recent years, tyrosine kinase inhibitors (TKIs) targeting angiogenesis have been applied treat ccRCC achieved profound therapeutic effects.It reported that patients receiving antiangiogenic will develop resistance within 15 months.The mechanism targeted extremely complex not clarified.Ovarian...
Abstract Background Tyrosine kinase inhibitors (TKIs) alone and in combination with immune checkpoint (ICIs) have been shown to be beneficial for the survival of metastatic renal cell carcinoma (mRCC) patients, but resistance targeted therapy ICIs is common clinic. Understanding underlying mechanism critical further prolonging cancer patients. Nuclear factor activated T 1 (NFAT1) expressed nonimmune cells, dysregulation NFAT1 contributes progression various type malignant tumors. However,...
Abstract With fusion or fission, mitochondria alter their morphology in response to various physiological and pathological stimuli, resulting elongated, tubular, interconnected, fragmented forms. Immunohistochemistry Western blot analysis were performed at 2 days, 7 14 28 days after 90 min of transient middle cerebral artery occlusion (tMCAO) mice. This study showed that mitochondrial fission protein dynamin‐related 1 (Drp1) optic atrophy (Opa1) both upregulated the ischemic penumbra, with...
Both transforming growth factor-beta (TGF-β) and lipopolysaccharide (LPS) can activate hepatic stellate cells (HSCs), thus increasing expressions of alpha smooth muscle actin (α-SMA) type I collagen 1 (Col1α1) promoting liver fibrosis.However, whether TGF-β LPS have a common downstream reactor remains unclear.Recently, strong relationship circular RNAs (circRNAs) fibrogenesis has been elucidated.In this study, we compared the several circRNAs in TGF-β-and LPS-activated HSCs, found that...
Abstract Background Early diagnosis of muscular tuberculosis (TB) without coexistent active skeletal involvement is often challenging because the disease very rare and its clinical manifestation nonspecific misleading. To raise awareness emphasize early TB, we present a case multiple tuberculous muscle abscesses in systemic lupus erythematosus (SLE) female, but pulmonary (PTB), order to increase stress need detection TB. Case presentation A 44-year-old woman with 6-year history SLE who had...
Stroke is the major cause of death and decrease in activities daily living. This study sought to evaluate effects commonly used antiplatelet drugs on spontaneous cerebral infarction relation neurovascular protection associated with angiogenesis pericyte proliferation. Stroke‐prone spontaneously hypertensive rats (SHR‐SP) were treated vehicle, aspirin, clopidogrel, or cilostazol from 8 10 weeks age. The interaction components among endothelial cells, pericytes, astrocytic endfeet...
Adolescent idiopathic scoliosis (AIS) is a complex genetic disorder characterized by three-dimensional spinal curvatures, affecting 2%-3% of school age children, yet the causes underlying AIS are not well understood. Here, we first conducted whole-exome sequencing and linkage analysis on three-generation Chinese family with autosomal-dominant (AD) AIS, then performed targeted in discovery cohort comprising 20 AD families 86 simplex patients, finally identified three disease-associated...
Introduction: Cutaneous malignant melanoma (CMM) is the most lethal form of skin cancer worldwide. The precise prediction lymph node metastasis critical for personalized treatment and improved patient outcomes. However, no prior study has employed interpretable machine learning techniques to predict in CMM. This aimed utilize integrate multidimensional data from Surveillance, Epidemiology, End Results (SEER) database—encompassing clinical characteristics, pathological information, biomarkers...
MicroRNAs (miRNAs) are small non-coding RNAs that silence their cognate target genes by specifically binding and cleaving messenger or inhibiting translation. In this study, we explored whether miRNA-141 miRNA-200b involved in regulation of the invasive ability epithelial-mesenchymal transition (EMT) bladder cancer cells vitro. We also evaluated potential as biomarkers for deciding extent pelvic lymph node dissection (PLND) required during radical cystectomy.Pri- anti-miR cell lines were...
Abstract Circular RNAs (circRNAs) are involved in the pathogenesis of certain renal diseases, however, function and mechanism them fibrosis remains largely unknown. In present study, RNA expression data unilateral ureteral obstruction (UUO) kidneys was obtained from our previous circRNA Microarray public Gene Expression Omnibus datasets to construct a ceRNA network. The effects target as long homologous human on examined vitro vivo. ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...
Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localizes the distal ends microtubules and regulate dynamics. We speculated it might be involved in epithelial-mesenchymal transition (EMT) progression bladder cancer (BC). Western blotting RT-PCR were used detect changes at mRNA levels BC cell lines. Cell proliferation, clonogenic formation, wound healing chamber invasion assay investigate abilities cellular migration...
Background: Anxiety-driven clinical interventions have been queried due to the nondeterminacy of pure ground-glass nodules (pGGNs). Although radiomics and radiogenomics aid diagnosis, standardization reproducibility challenges persist. We aimed assess a risk score system for invasive adenocarcinoma in pGGNs. Methods: In retrospective, multi-center study, 772 pGGNs from 707 individuals The Affiliated Cancer Hospital Zhengzhou University & Henan were grouped into training (509 patients with...
Abstract Detection and protection of the neurovascular unit (NVU) are essential for treatment acute stroke patients, especially use tissue plasminogen activator (tPA). In present study, we conducted in vivo ex optical imaging detecting activation matrix metalloproteinases (MMPs) evaluated protective effect intracerebral transplantation bone marrow stromal cells (BMSCs) obtained from green fluorescent protein (GFP) transgenic (Tg) mice on NVU tPA‐mediated brain damage after transient middle...
Aim: Low grade glioma (LGG) is a lethal brain cancer with relatively poor prognosis in young adults. Thus, this study was performed to develop novel molecular biomarkers effectively predict the of LGG patients and finally guide treatment decisions. Methods: survival-related genes were determined by Kaplan-Meier survival analysis multivariate Cox regression using expression clinical data 506 from The Cancer Genome Atlas (TCGA) database independently validated Chinese Glioma (CGGA) dataset. A...
Renal cell carcinoma (RCC) is a kind of malignant tumor originating from the renal tubular epithelium. Approximately 30% patients with cancer are found to have metastasis when first diagnosed. Exploring other effective treatment methods in addition surgery an urgent need research field carcinoma. Polybromo 1 (PBRM1) second most mutated gene RCC, mutation rate ~40%. Notably, posttranscriptional modification PBRM1 RCC unclear. In this study, we performed unbiased mass spectrometry and...