A5101542801- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- Cardiovascular Effects of Exercise
- Nanoparticle-Based Drug Delivery
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Heat shock proteins research
- Viral Infections and Vectors
- Reconstructive Surgery and Microvascular Techniques
- Diabetes Management and Education
Guangdong Provincial Center for Disease Control and Prevention
2015-2024
Jiangsu T-mab BioPharma (China)
2024
Gannan Normal University
2022
Zhejiang Chinese Medical University
2022
Guangzhou Vocational College of Science and Technology
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2021
Beijing Hospital
2018-2021
Case Western Reserve University
2021
Southern Medical University
2019-2020
Peking Union Medical College Hospital
2019
The reduced protein expression of SIRT6 tumor suppressor is involved in tumorigenesis. molecular mechanisms underlying downregulation human cancers remain unknown. Using a proteomic approach, we have identified the ubiquitin-specific peptidase USP10, another suppressor, as one SIRT6-interacting proteins. USP10 suppresses ubiquitination to protect from proteasomal degradation. antagonizes transcriptional activity c-Myc oncogene through SIRT6, well p53, inhibit cell-cycle progression, cancer...
The ubiquitin pathway plays critical roles in antigen presentation. However, the ligases that regulate MHC gene transcription remain unidentified. We showed ligase Hrd1, expression of which is induced by Toll-like receptor (TLR) stimulation, required for MHC-II but not MHC-I dendritic cells (DCs). Targeted Hrd1 deletion DCs diminished expression. As a consequence, Hrd1-null failed to prime CD4+ T without affecting activation CD8+ cells. catalyzed ubiquitination and degradation...
The elevated level of CCNB1 indicates more aggressive cancer and poor prognosis. However, the factors that cause upregulation remain enigmatic. Herein, we identify USP22 as a interactor discover both are dramatically with strong positive correlation in colon tissues. stabilizes by antagonizing proteasome-mediated degradation cell cycle-specific manner. Phosphorylation CDK1 enhances its activity deubiquitinating CCNB1. ubiquitin ligase anaphase-promoting complex (APC/C) targets for using...
Identification of positive regulators T-cell immunity induced during autoimmune diseases is critical for developing novel therapies. The endoplasmic reticulum resident ubiquitin ligase Hrd1 has recently emerged as a regulator dendritic cell antigen presentation, but its role in unknown. Here we show that genetic deletion mice inhibits proliferation, production IL-2, and differentiation Th1 Th17 cells, consequently protects from experimental encephalomyelitis. facilitates proliferation by the...
The usage of doxorubicin is hampered by its life-threatening cardiotoxicity in clinical practice. Dexrazoxane the only cardioprotective medicine approved FDA for preventing doxorubicin-induced cardiac toxicity. Nevertheless, mechanism dexrazoxane incompletely understood. aim our study to investigate possible molecular against cardiotoxicity. We established a mouse and cardiomyocyte injury model. Male C57BL/6J mice were randomly distributed into control group (Con), treatment (DOX), plus...
Guangdong province attracted more than 31 million migrants in 2010. But few studies were performed to estimate the complete and age-appropriate immunization coverage determine risk factors of migrant children. 1610 children aged 12–59 months from 70 villages interviewed Guangdong. Demographic characteristics, primary caregiver's knowledge attitude toward immunization, child's history obtained. UTD rates for following five vaccines overall series (1:3:3:3:1 series) assessed: one dose BCG,...
Herpes zoster (HZ) exists widely in China and most cases occur among old people, but no epidemiology information of HZ was available. We aimed to investigate the characteristics adults aged 50 over Guangdong, China. A total 34 counties/districts were randomly selected 7149 residents investigated by local CDC professionals using accidental sampling method. There 247 respondents having had before; lifetime prevalence people above study area 3.46%. The females higher than that males. Pearl...
To provide a scientific basis for the prevention and treatment of cervical cancer (CC), we investigated distribution characteristics genotypes human papillomavirus (HPV) prevalence multiple HPV infections in women different ages seeking management abnormal cytology Foshan City. Screening 21 was carried out 9945 females results using rapid flow-through hybridization nucleic acid molecules. The overall prevalence, genotype age-specific were examined. Our indicate that overall, high-risk,...
Currently, the sole treatment option for patients with heart failure is transplantation. The battle of prolonging graft survival and modulating innate adaptive immune responses still being waged in clinic research labs. transcription factor Nrf2 controls major cell pathways central to moderating inflammation responses. In this study effect levels host recipient C57BL/6 mice on Balb/c allogeneic was examined. Importantly, Nrf2(-/-) could not support longer than 7.5 days average, whereas...
Abstract Alternative NF-κB signaling is crucial for B cell activation and Ig production, it mainly regulated by the inhibitor of κ kinase (IKK) regulatory complex. Dysregulation alternative in cells could therefore lead to hyperactive overproduction. In our previous, study we found that deleted breast cancer 1 (DBC1) a suppressor pathway attenuate activation. this study, report loss DBC1 results spontaneous overproduction mice after 10 mo age. Using double mutant genetic model, confirm...
Regulated necrosis (necroptosis) is crucially involved in cardiac ischaemia-reperfusion injury (MIRI). The aim of our study to investigate whether shock wave therapy (SWT) capable exerting protective effects by inhibiting necroptosis during myocardial (I/R) and the possible role autophagy this process. We established a hypoxia/reoxygenation (H/R) model vitro using HL-1 cells simulate MIRI. MTS assays LDH cytotoxicity assay were performed measure cell viability damage. Annexin V/PI staining...
CD40 and BAFFR signaling play important roles in B cell proliferation Ig production. In this study, we found that cells from mice with deletion of Dbc1 gene (Dbc1(-/-)) show elevated proliferation, IgG1 IgA production upon vitro BAFF, but not BCR LPS stimulation, indicating DBC1 inhibits CD40/BAFF-mediated activation a cell-intrinsic manner. Microarray analysis chromatin immunoprecipitation experiments reveal function by selectively suppressing the transcriptional activity alternative NF-κB...
This study aimed to develop and validate a simple risk score for detecting individuals with impaired fasting glucose (IFG) among the Southern Chinese population. A sample of participants aged ≥20 years without known diabetes from 2006–2007 Guangzhou cross-sectional survey was used separate scores men women. The completed self-administered structured questionnaire underwent clinical measurements. were developed by multiple logistic regression analysis. External validation performed based on...
Adiponectin is a small peptide secreted and key component of the endocrine system immune system. Although globular adiponectin protects myocardial ischemia/reperfusion-induced cardiomyocyte injury, protective mechanisms remain largely unresolved. Using neonatal rat ventricular myocyte hypoxia/reoxygenation model, we investigated role its potential necroptosis in adiponectin-mediated protection hypoxia/reoxygenation-induced injury as compared to apoptosis. We found that treatment attenuated...
Abstract Background: Anti-CD3-based bispecific T cell engagers (BiTE) showed limited clinical efficacy in solid tumors and caused significant cytokine storm. Similar to BiTE where cells are activated by CD3 antibody, we constructed a novel bi-specific macrophage engager (BiME) platform is anti-SIRPa that directed particular tumor via the targeting of tumor-associated antigen (TAA), resulting phagocytosis cells. This BiME does not lead storm particularly applicable for treatment whose...
Cardiac shock wave therapy (SWT) has been described as a novel therapeutic strategy that is able to alleviate myocardial ischemic injury. microRNA (miRNA/miR)‑210 plays cytoprotective role in cardiomyocytes response hypoxia by regulating cell apoptosis. The aim of the present study was investigate whether cardiac SWT could protect from hypoxia‑induced injury miR‑210 expression. murine adult cardiomyocyte line HL‑1 incubated for 5 h hypoxic conditions, followed reoxygenation 12 and treatment...
e14523 Background: Adenosine and TGF-β are two key immune suppressors in tumor microenvironment (TME) that cause broad suppression resulting resistance to current CPI immunotherapies. Cancer cells, other cell types within TME, frequently express TGFβ, which inhibits CD8 + T Th1 cells promotes epithelial–mesenchymal transition. We have designed a bi-specific targeting molecules blocking the inhibitory pathways, aiming create an immune-friendly TME. Methods: created bifunctional...
In 2019, we conducted a cross-sectional study for polio virus seroprevalence in Guangdong province, China. We assessed the positivity rates of poliomyelitis NA and GMT serum across various demographic groups, current findings were compared with pre-switch data from 2014. Using multistage random sampling method, four counties/districts randomly selected per city, within each, one general hospital two township hospitals chosen. Healthy individuals coming medical checkups or vaccination...
<h3>Background</h3> TGF-β has a dual action in different tumor cells at stages, exerting context-dependent effects as suppressor and promoter. In early-stage cancers, signaling suppresses formation. advanced acquires range of tumor-promoting effects, including on immune cells, endothelial cancer-associated fibroblasts within the microenvironment. To selectively inhibit its pro-tumorigenic while preserving suppressive we have developed bifunctional antibody-ligand trap called ES014 which...