A5100687046- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Acupuncture Treatment Research Studies
- Parathyroid Disorders and Treatments
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Biomarkers in Disease Mechanisms
- Ubiquitin and proteasome pathways
- Spinal Cord Injury Research
- Myofascial pain diagnosis and treatment
- Neonatal and fetal brain pathology
- Peptidase Inhibition and Analysis
- Atherosclerosis and Cardiovascular Diseases
Zhujiang Hospital
2015-2025
Southern Medical University
2015-2025
China Pharmaceutical University
2022-2025
Affiliated Hospital of Taishan Medical University
2024
Shandong First Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Wangjing Hospital of China Academy of Chinese Medical Sciences
2024
Chongqing Medical University
2023-2024
Shandong University
2023
Hainan Provincial Hospital of Traditional Chinese Medicine
2023
Although many self-reactive T cells are eliminated by negative selection in the thymus, some of these escape into periphery, where they must be controlled additional mechanisms. However, molecular mechanisms underlying peripheral cell tolerance and its maintenance remain largely undefined. In this study, we report that sirtuin 1 (Sirt1), a type III histone deacetylase, negatively regulates activation plays major role clonal anergy mice. vivo, found loss Sirt1 function resulted abnormally...
Abstract Vascular calcification is a common pathologic condition in patients with chronic kidney disease (CKD) and aging individuals. It has been established that vascular gene‐regulated biological process resembling osteogenesis involving osteogenic differentiation. However, there no efficient treatment available for so far. The natural polyamine spermidine demonstrated to increase life span protect against cardiovascular disease. unclear whether supplementation inhibits CKD. Alizarin red...
Vascular calcification (VC) is prevalent in pathological processes such as diabetes, chronic kidney disease (CKD), and atherosclerosis, but effective therapies are still lacking by far. Canagliflozin (CANA), a sodium-glucose cotransporter 2 inhibitor, has been approved for the treatment of type diabetes mellitus exhibits beneficial effects against cardiovascular disease. However, effect CANA on VC remains unknown. In this study, we hypothesize that protects VC.Micro-computed tomography...
Abstract Vascular calcification is an actively regulated process resembling bone formation and contributes to the cardiovascular morbidity mortality of chronic kidney disease (CKD). However, effective therapy for vascular still lacking. The ketone body β‐hydroxybutyrate (BHB) has been demonstrated have health‐promoting effects including anti‐inflammation protective effects. whether BHB protects against in CKD remains unclear. In this study, Alizarin Red staining calcium content assay showed...
Abstract Vascular calcification is an actively regulated biological process resembling bone formation, and osteogenic differentiation of vascular smooth muscle cells (VSMCs) plays a crucial role in this process. 1‐Palmitoyl‐2‐(5′‐oxo‐valeroyl)‐sn‐glycero‐3‐phosphocholine (POVPC), oxidized phospholipid, found atherosclerotic plaques has been shown to induce oxidative stress. However, the effects POVPC on VSMCs have yet be studied. In present study, we investigated using vitro ex vivo models....
We have investigated the plasma proteome by using 2D gel electrophoresis and MS from patients with severe acute respiratory syndrome (SARS). A complete proteomic analysis was performed on four SARS in different time courses, a total of 38 differential spots were selected for protein identification. Most proteins identified are phase proteins, their presence represents consequence serial cascades initiated SARS-coronavirus infection. There several that never been before electrophoresis, among...
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), key in chaperone-mediated autophagy (CMA) pathway, is elevated breast tumor tissues. However, exact effects and mechanisms CMA during cancer metastasis remain largely unknown. In this study, we found LAMP2A level was significantly human tissues, particularly metastatic carcinoma. The increased also positively correlated with histologic grade ductal cancer. High levels predicted shorter...
Ferroptosis is a novel form of programmed cell death that triggered by iron-dependent lipid peroxidation. Brusatol (BRU), natural nuclear factor erythroid 2-related 2 inhibitor, exhibits potent anticancer effects in various types cancer. However, the exact mechanism BRU treatment hepatocellular carcinoma (HCC) remains unknown. The HCC were detected using counting kit-8 and colony formation assays xenograft model. RNA sequencing (RNA-seq) bioinformatics analyses cells utilized to elucidate...
Decoy receptor 3 (DCR3) halts both Fas ligand– and LIGHT-induced cell deaths, which are required for pancreatic β damage in autoimmune diabetes. To directly investigate the therapeutic potential of DCR3 preventing this disease, we generated transgenic nonobese diabetic mice, overexpressed cells. Transgenic protected mice from cyclophosphamide-induced diabetes a dose-dependent manner significantly reduced severity insulitis. Local expression transgene did not alter diabetogenic properties...
In this study, we seek to determine independent risk factors of invasive fungal infection (IFI) in neonatal infants.The medical charts 5135 intensive care unit admissions the past 7 years between January 2004 and December 2010 were reviewed 45 neonates found with IFI. Two controls, matched by gestational age, birth weight category, admission date, ward, hospital stay, selected for each case.Candida parapsilosis was leading causative pathogen IFI isolated 33.3% patients. The mortality rate...
Introduction Local anesthetic blockade of the genicular nerves, known targets radiofrequency ablative techniques for knee pain, has not previously been studied in a randomized controlled trial evaluating acute pain after arthroplasty. We hypothesized that nerve added to an existing block regimen total arthroplasty would result reduction 24 hours opioid consumption. Methods Patients (American Society Anesthesiologists 1–3, aged 18–85 years) undergoing primary were receive single-injection...
Farnesoid X receptor (FXR) is widely accepted as a promising target for various liver diseases; however, panels of ligands in drug development show limited clinical benefits, without clear mechanism. Here, we reveal that acetylation initiates and orchestrates FXR nucleocytoplasmic shuttling then enhances degradation by the cytosolic E3 ligase CHIP under conditions injury, which represents major culprit limits benefits agonists against diseases. Upon inflammatory apoptotic stimulation,...
Abstract Vascular calcification is an important risk factor related to all‐cause mortality of cardiovascular events in patients with chronic kidney disease (CKD). extracellular matrix (ECM) proteins have been demonstrated regulate vascular calcification. ECM protein thrombospondin 1 (THBS1/TSP‐1) plays a critical role the regulation diseases. However, whether THBS1 involved CKD remains unclear. In this study, RNA sequencing datasets from Gene Expression Omnibus (GEO) database GSE146638...
ABSTRACT Vascular calcification is an independent predictor of cardiovascular mortality in patients with chronic kidney disease (CKD), yet no approved treatment exists. The cGAS‐STING signaling participates various diseases. Notably, DNA damage, important regulator vascular calcification, activates the signaling. However, it remains poorly understood whether STING regulates under CKD conditions. In current study, we showed that expression was elevated during calcification. knockdown or...
Coamorphous drug delivery systems have emerged as a promising formulation strategy to enhance the solubility, oral bioavailability, and physical stability of poorly water-soluble drugs. The molar ratio components in coamorphous plays critical role determining their stability. In this study, we investigated crystallization behavior celecoxib-carbamazepine (CEL-CBZ) at different ratios. growth rates CEL crystals, CBZ CEL-CBZ cocrystals were observed exhibit distinct dependencies on systems,...
Introduction: Electron microscopy (EM) is a crucial technique for identifying and distinguishing the specific location of deposits within glomeruli. Manual classification these deposit locations are not only time-consuming but also yields inconsistent results among pathologists. This study aimed to develop deep learning -based platform automatically classify electron-dense in EM images kidney biopsies. Methods: We retrospectively collected 4303 at magnifications 4000X 8000X from 1039...