A5103167448- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Cancer Treatment and Pharmacology
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Medical Research and Treatments
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Sinusitis and nasal conditions
- Neutropenia and Cancer Infections
- Lung Cancer Treatments and Mutations
- Olfactory and Sensory Function Studies
- Voice and Speech Disorders
- Heart Failure Treatment and Management
- Colorectal Cancer Treatments and Studies
- Antimicrobial Peptides and Activities
- Nasal Surgery and Airway Studies
- Metastasis and carcinoma case studies
- Chronic Myeloid Leukemia Treatments
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Reproductive Biology and Fertility
- Breast Lesions and Carcinomas
- Respiratory and Cough-Related Research
Taiyuan Central Hospital
2009-2025
Guangzhou University of Chinese Medicine
2009-2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2008-2025
First Hospital of Shijiazhuang
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Southwest University
2024
RELX Group (United States)
2024
Chongqing Medical University
2024
Hebei Medical University
2022
Abstract Polycystic ovary syndrome (PCOS) is an endocrine disorder that occurs in women of reproductive age. Anovulation caused by abnormal follicular development still the main characteristic PCOS patients with infertile. Granulosa cell (GC) important part microenvironment, dysfunction which can affect development. Increasing evidence indicates exosomal miRNAs derived from fluid (FF) play critical roles during PCOS. However, fluid-derived a pivotal role controlling granulosa function and...
Ferroptosis is a novel form of programmed cell death that triggered by iron-dependent lipid peroxidation. Brusatol (BRU), natural nuclear factor erythroid 2-related 2 inhibitor, exhibits potent anticancer effects in various types cancer. However, the exact mechanism BRU treatment hepatocellular carcinoma (HCC) remains unknown. The HCC were detected using counting kit-8 and colony formation assays xenograft model. RNA sequencing (RNA-seq) bioinformatics analyses cells utilized to elucidate...
Abstract Background Acute pharyngitis is frequently seen in primary care. viral may be easily misdiagnosed as acute bacterial pharyngitis. Laboratory-confirmed diagnosis of respiratory viruses recommended. The purpose this study was to compare the sensitivities among oropharyngeal swab (OPS), nasopharyngeal (NPS), and nasal wash (NW) adults with Methods OPS, NPS, NW were obtained from each participant specimens tested for 15 by TaqMan real-time polymerase chain reaction. A sample considered...
Background: 5-Fluorouracil (5-FU) is the most widely used chemotherapy drug, primarily against gastrointestinal, head and neck, breast cancers. 5-FU has large pharmacokinetic variability resulting in unexpected toxicity or ineffective treatment. Therapeutic drug management of minimizes improves outcome. A nanoparticle-based immunoassay was developed to provide oncologists with a rapid, cost-effective tool for determining plasma concentrations. Methods: Monoclonal antibodies, bound...
Aims This prospective, randomized study was initiated to assess the impact of pharmacokinetically (PK)‐guided paclitaxel (PTX) dosing on toxicity and efficacy compared with body‐surface area (BSA)‐based in Chinese non‐small cell lung cancer patients. Methods A total 319 stage IIIB/IV patients receiving first‐line chemotherapy were enrolled. Patients receive 3‐weekly carboplatin plus PTX at a starting dose 175 mg/m 2 subsequent based either BSA or PK‐guided targeting time above plasma...
<title>Abstract</title> <bold>Objectives</bold> To compare the effect of low-flow mask oxygenation (LFMO) with breathing training (BT) for psychogenic hyperventilation syndrome (PHVS), providing more options and evidence clinical treatment. <bold>Methods</bold> A randomized double-blinded controlled experiment was registered in Chinese Clinical Trial Registry on 01/06/2023 a defined number (ChiCTR2300072044) approved by Ethics Committee (REDACT) (GYZXLL2023070) then conducted there from 10...
Rhinosinusitis is an inflammation of the paranasal sinuses and nasal cavity. It managed with intra-nasal steroids, saline irrigation, oral antibiotics and/or biologics. Chinese herbal medicines (CHMs) have long been used for disorders, including rhinosinusitis, feature in clinical guidelines rhinosinusitis. Systematic reviews suggest some CHM formulations may be beneficial management this condition. This text mining study established methodology to search a database containing full texts...
To evaluate the clinical efficacy of a high-efficiency air purifier in patients with allergic rhinitis.We conducted randomised, double-blind, controlled trial active and inactive versions an purifier. Our study included rhinitis who were sensitive to Artemisia pollen treatment indoor environment using filtration at night. We evaluated during scattering season Yulin City Shanxi Province, China.The First Hospital (Yulin City, China).A total 90 allergens randomly assigned one two groups equal...
Radix Astragali (RA) has been recognized for its therapeutic potential in allergic rhinitis (AR), yet pharmacological mechanisms remain elusive. This study systematically investigated the physicochemical properties and biological activities of RA's phytochemicals, aiming to elucidate their targets AR treatment. We identified 775 key phytochemicals intersected these with 29,544 AR-related disease targets, pinpointing 747 shared targets. A protein-protein interaction network analysis...
Self-supervised learning achieves close to supervised results on remote sensing image (RSI) scene classification. This is due the current popular self-supervised methods that learn representations by applying different augmentations images and completing instance discrimination task which enables convolutional neural networks (CNNs) invariant augmentation. However, RSIs are spatial-temporal heterogeneous, means similar features may exhibit characteristics in scenes. Therefore, performance of...
Background Perennial allergic rhinitis (PAR) has a high and increasing prevalence worldwide. Ear acupressure (EAP) is noninvasive semi–self-administered form of acupuncture. Previous studies indicated that EAP could be effective safe for AR symptom management. However, there was insufficient evidence to confirm this. This study investigated whether EAP, clinical alternative acupuncture, PAR. Methods an international, multicenter, randomized, single-blind, sham-controlled trial. The trial...
High-dose busulfan is an important component of many bone marrow transplantation-preparative regimens. High plasma levels have been shown to increase the chance venoocclusive disease and low are associated with recurrence or graft rejection. Currently, monitored by physical methods that expensive time consuming, resulting in relatively overall use testing for dose adjustment. Novel highly selective antibodies generated a microtiter plate immunoassay capable quantifying has developed. The...
3574 Background: Multiple studies have demonstrated how PK-guided dosing to optimize infusional 5FU exposure improves both response rates and toxicities. With PK testing now available using a rapid, reliable immunoassay, we present US-based oncologists' experience with individualizing based on in patients adjuvant or metastatic CRC. Methods: Between June 5, 2013 January 17, 2014, Saladax Biomedical Laboratories (a CLIA-certified lab) determined plasma levels (My5-FU assay) 631 samples...
Area under time-concentration curve (AUC) of docetaxel is related with its toxicity and efficacy. The aim this study to investigate the target range AUC in Chinese head neck cancer (HNC) patients.Eligible HNC patients were enrolled received at least 2 cycles docetaxel-based chemotherapy. A simplified pharmacokinetic (PK) strategy (2 monitored samples) was developed simulate using nonlinear mixed-effect modelling program. Preliminary pre-set as 2.5-3.7 µg·hr/mL according pooled analysis from...
Allergic rhinitis is a global health problem that can potentially be managed through acupressure. Our clinical observations have identified Rhinitis Acupressure Therapeutic (ARAT) as novel acupressure treatment acting on specific acupoints, which may enhance the effectiveness of Therefore, we propose three-arm randomized controlled trial will conducted to investigate efficacy and safety ARAT for perennial allergic (PAR).In this trial, eligible 111 participants diagnosed with PAR randomly...
Paclitaxel (PTX; Taxol, Abraxane) is used in many regimens for breast cancer, non-small cell lung cancer (NSCLC), and ovarian cancer. Multiple studies have demonstrated that PTX exhibits a greater than 10-fold interpatient variability of clearance rates when patients are dosed according to body surface area (BSA). Pharmacokinetic pharmacodynamic relationships been elucidated from BSA-based dosing. candidate dose management, shown therapeutic management (TDM) feasible may provide improved...
Background: Docetaxel (Taxotere) (DTX) is a widely used chemotherapy agent in many regimens for the treatment of solid tumors, example breast cancer, non–small cell lung gastric, prostate, and head neck cancers. This drug meets criteria therapeutic dose management, that it associated with high pharmacokinetic variability dose-limiting toxicity; has narrow window, there significant pharmacokinetic–pharmacodynamic relationship. Measures exposure area under time–concentration curve have been...