A5056287019- Bone health and osteoporosis research
- Forensic Toxicology and Drug Analysis
- Vitamin D Research Studies
- Poisoning and overdose treatments
- Metabolism and Genetic Disorders
- Monoclonal and Polyclonal Antibodies Research
- Pesticide Residue Analysis and Safety
- Clinical Laboratory Practices and Quality Control
- Antibiotics Pharmacokinetics and Efficacy
- Metabolomics and Mass Spectrometry Studies
- Glycosylation and Glycoproteins Research
- Growth Hormone and Insulin-like Growth Factors
- Complementary and Alternative Medicine Studies
- Pain Management and Opioid Use
- Opioid Use Disorder Treatment
- Multiple Myeloma Research and Treatments
- Bone Metabolism and Diseases
- Pediatric health and respiratory diseases
- Mercury impact and mitigation studies
- Ethics in Clinical Research
- Congenital Diaphragmatic Hernia Studies
- Cancer Risks and Factors
- Carcinogens and Genotoxicity Assessment
- Botanical Research and Chemistry
- Diet and metabolism studies
University of North Carolina Health Care
2016-2018
University of North Carolina at Chapel Hill
2007-2016
University of North Carolina Hospitals
2003-2008
University of Florida
1998-2000
Florida College
1998
United States Air Force
1995
Opioid misuse can complicate chronic pain management, and the non-medical use of opioids is a growing public health problem. The incidence risk factors for opioid in patients with pain, however, have not been well characterized. We conducted prospective cohort study to determine one-year predictors among enrolled disease management program within an academic internal medicine practice.One-hundred ninety-six opioid-treated chronic, non-cancer at least three months duration were monitored...
Abstract Few antimicrobial drugs meet the requirements for therapeutic drug monitoring. Those that are monitored include aminoglycosides (gentamicin, tobramycin, and amikacin), chloramphenicol, in some cases, vancomycin. For these drugs, there is evidence of a relationship between serum concentration, efficacy, and/or incidence adverse or toxic events. Monitoring begins with appropriate timing collection continues through analytical process to integration all data used guide clinician’s next...
Abstract Background: Cerebrospinal fluid (CSF) leaks are potentially life-threatening conditions that can be diagnosed by detection of β 2 -transferrin using protein electrophoresis. Another less commonly available test is β-trace quantitation immunoassay. The objectives this study were to evaluate a new immunofixation-based for CSF and compare it an existing agarose gel electrophoresis Methods: For method comparison, 63 consecutive samples from physician-ordered tests analyzed two different...
The AACC Academy, formerly the National Academy of Clinical Biochemistry, has developed a laboratory medicine practice guideline (LMPG)10 for using tests to monitor drug therapy in pain management patients. purpose this was compile evidence-based recommendations use and point-of-care (POC) urine relevant over-the-counter medications, prescribed nonprescribed drugs, illicit substances exact process preparing publishing LMPG is shown Table 1. View table: Table 1. Process...
The objective of this study was to compare gel- and capillary-based serum protein electrophoresis methods identify characterize monoclonal immunoglobulins (M proteins). Five reviewers interpreted 149 consecutively ordered specimens following agarose gel (AGE), capillary (CE), immunofixation (IFE), subtraction immunotyping (IT). As a screening test for detecting M proteins, AGE CE displayed similar sensitivity (91% 92%, respectively). less specific (74%) than (81%). An analysis...
Background: 5-Fluorouracil (5-FU) is the most widely used chemotherapy drug, primarily against gastrointestinal, head and neck, breast cancers. 5-FU has large pharmacokinetic variability resulting in unexpected toxicity or ineffective treatment. Therapeutic drug management of minimizes improves outcome. A nanoparticle-based immunoassay was developed to provide oncologists with a rapid, cost-effective tool for determining plasma concentrations. Methods: Monoclonal antibodies, bound...
The relative importance of body composition, lifestyle factors, bone turnover and hormonal factors in determining mineral density (BMD) is unknown. We studied younger postmenopausal women to determine whether modifiable or nonmodifiable risk for osteoporosis have stronger associations with BMD.In multivariable linear regression models, we tested between non-bone composition measures, self-reported measures physical activity dietary intake, urinary N-telopeptide (NTx), sex hormone...