A5044283170- Muscle Physiology and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Clinical Laboratory Practices and Quality Control
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- Prenatal Substance Exposure Effects
- Chronic Kidney Disease and Diabetes
- Poisoning and overdose treatments
- Erythropoietin and Anemia Treatment
- Intestinal Malrotation and Obstruction Disorders
- Congenital heart defects research
- Health and Medical Research Impacts
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Body Composition Measurement Techniques
- Metabolomics and Mass Spectrometry Studies
- Blood groups and transfusion
- Chemical synthesis and alkaloids
- Metabolism and Genetic Disorders
- Silk-based biomaterials and applications
- Analytical Chemistry and Chromatography
- Neonatal Respiratory Health Research
- Adenosine and Purinergic Signaling
- HIV/AIDS drug development and treatment
- Hemodynamic Monitoring and Therapy
University of North Carolina at Chapel Hill
2012-2025
University of North Carolina Health Care
2023-2024
University of Delaware
2022
American Association for Clinical Chemistry
2020
American Society for Clinical Pathology
2020
Genomics (United Kingdom)
2019
Institute for Transfusion Medicine
2019
The Ohio State University Wexner Medical Center
2013-2018
The Ohio State University
2012-2016
Columbia University Irving Medical Center
1980
Abstract Background Chloride is an extracellular anion commonly measured using ion-selective electrode methods standardized to traceable reference materials. This study investigates the gradual appearance of a positive bias in chloride measurements Siemens Healthineers Atellica CH platform that was undetectable via routine quality control or proficiency testing. Methods The characterized retrospective analysis laboratory values from presumable healthy outpatients (ICD-10 code Z00.00),...
(R)-Lacosamide ((R)-2, (R)-N-benzyl 2-acetamido-3-methoxypropionamide) has recently gained regulatory approval for the treatment of partial-onset seizures in adults. Whole animal pharmacological studies have documented that (R)-2 function is unique. A robust strategy advanced discovery interacting proteins associated with and toxicity through use analogues, 3, which contain "affinity bait (AB)" "chemical reporter (CR)" functional groups. In covalent modification proceeds at AB moiety,...
Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes and regeneration. Dystrophin-deficient mdx mice in which myostatin knocked out or inhibited postnatally have less severe phenotype with greater total mass strength fibrosis fatty replacement muscles than wild-type expression. Dogs golden retriever muscular dystrophy (GRMD) previously been noted to increased reduced after systemic postnatal inhibition. Based partly on these results, inhibitors are development...
Screening for chronic kidney disease relies on accurate and precise creatinine measurements. Traditionally, is measured in serum or plasma using high-throughput chemistry analyzers. However, dried blood spots (DBS) can also be utilized to improve testing access. Samples were obtained from a 6mm DBS punch, which was reconstituted water before undergoing an acetonitrile crash. The resulting supernatant diluted 80:20 acetonitrile: injection. Creatinine identified isocratic gradient, detected...
Nucleobindin‐1 (NUCB1) and nucleobindin‐2 (NUCB2) are multifunctional proteins that interact with Ca 2+ , nucleic acids various regulatory in different signaling pathways. So far, our understanding of the regulation biological functions nucleobindins remains limited. In proteome‐wide selection for downstream caspase substrates, both NUCB1 NUCB2 found to be substrates caspases. We report here detailed analyses cleavage by Significantly, sites located exactly at one ‐binding EF‐hand motifs....
Abstract mRNA‐display is an amplification‐based, iterative rounds of in vitro protein selection technique that circumvents a number difficulties associated with yeast two‐hybrid and phage display. Because the covalent linkage between genotype phenotype, provides powerful means for reading amplifying peptide or sequence after it has been selected from library diversity range 10 12 –10 13 . In this paper, we briefly review recent progress using to identify affinity reagents, binding partners,...
Abstract Background Racial disparities in SARS-CoV-2 prevalence are apparent. Race is a sociocultural construct, necessitating investigation into how factors contribute. Methods This cross-sectional study linked laboratory data of adult patients between February 29 and May 15, 2020 with socio-demographics variables from the 2018 American Community Survey (ACS). Medical sites included healthcare organizations Michigan, New York, North Carolina, California, Florida, Pennsylvania, Washington....
Interpretation of body fluid (BF) results is based on published studies and clinical guidelines. The aim this study to determine whether the assays from five common commercial vendors produce similar in BFs for 12 analytes a BF cohort.BFs (n = 25) serum 5) were analyzed instruments (Roche cobas c501, Ortho 5600, Beckman AU5800 DXI800, Siemens Vista 1500, Abbott Architect c8000) measure albumin, amylase, total bilirubin, cholesterol, creatinine, glucose, lactate dehydrogenase (LDH), lipase,...
Patient: 1-month-old male