A5114374733- Synthesis and biological activity
- Metal complexes synthesis and properties
- Molecular Sensors and Ion Detection
- Crystal structures of chemical compounds
- DNA and Nucleic Acid Chemistry
- Magnetism in coordination complexes
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Melanoma and MAPK Pathways
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Luminescence and Fluorescent Materials
- X-ray Diffraction in Crystallography
- Porphyrin and Phthalocyanine Chemistry
- Synthetic Organic Chemistry Methods
- Cytokine Signaling Pathways and Interactions
- Asymmetric Synthesis and Catalysis
- Click Chemistry and Applications
- Crystallography and molecular interactions
- Cancer Mechanisms and Therapy
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Cancer therapeutics and mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
Guangdong Academy of Sciences
2020-2025
Institute of Zoology
2021-2025
University of Washington
2025
Nanjing University of Chinese Medicine
2025
Shanghai Institute of Pharmaceutical Industry
2023
Sun Yat-sen University
2022
Fifth Affiliated Hospital of Sun Yat-sen University
2022
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Southwest University
2021
Novel indazole and benzimidazole analogues were designed synthesized as tubulin inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the strongest inhibitory effects on growth of cancer cells an average IC50 value 50 nM, slightly better than colchicine. nearly equal potency against both, a paclitaxel-resistant cell line (A2780/T, = 9.7 nM) corresponding parental (A2780S, 6.2 nM), thus effectively overcoming paclitaxel resistance in vitro. The crystal...
The one-step synthetic strategy for the preparation of hitherto unknown calix[3]carbazole from readily available starting materials is described. Calix[3]carbazole obtained in 20% yield, and it could selectively bind N(C2H5)4(+) cation (tetraethylammonium, TEA) via cation-π interactions. experimental modeling results indicate that possesses a larger π-cavity as well better chromophoric property than traditional phenol-based macrocycles, thus capable binding to optically responding relatively...
Background Patient‐derived organoid (PDO) models are highly valuable and have potentially widespread clinical applications. However, limited information is available regarding of non‐small cell lung cancer (NSCLC). This study aimed to characterize the consistency between primary tumors in NSCLC PDOs explore applications as preclinical understand predict treatment response during cancer. Methods Fresh tumor samples were harvested for culture. Primary analyzed via whole‐exome sequencing....
The polysaccharides from Stemona tuberosa Lour, a kind of plant used in Chinese herbal medicine, have various pharmacological activities, such as anti-inflammatory and antioxidant properties. However, the effects extraction methods activity different parts are still unknown. Therefore, this study aimed to evaluate on yields, chemical compositions, bioactivity extracted Lour. Six were leaves, roots, stems Lour through use hot water (i.e., SPS-L1, SPS-R1, SPS-S1) an ultrasound-assisted method...
A highly stereoselective [4 + 3] cycloaddition of N-substituted pyrroles with allenamide-derived nitrogen-stabilized chiral oxyallyl cations is described here. This method provides an approach for constructing tropinone alkaloids.
Acute lung injury (ALI) is an inflammation-mediated respiratory disease with a high mortality rate. Medications anti-inflammatory small molecules have been demonstrated in phase I and II clinical trials to considerably reduce the ALI mortality. In this study, two series of lansiumamide analogues were designed, synthesized, evaluated for activity treatment. We found that compound 8n exhibited best through inhibiting LPS-induced expression proinflammatory cytokines interleukin-6 (IL-6)...
The ground film of a triphenylamine modified benzothiazole derivative can detect volatile acid vapors with high performance.
Pulmonary inflammation is the main cause of lung injury. Phosphodiesterase 4 (PDE4) a promising anti-inflammatory target for treatment respiratory diseases. Herein, we designed and synthesized 43 compounds in two novel series benzimidazole derivatives as PDE4 inhibitors. Among them, compound A5 showed highly selective inhibition PDE4, good safety, liver microsomal stability vitro. administration remarkably attenuated inflammatory infiltration pathologic injury models acute mice chronic...
For partially observable cooperative tasks, multi-agent systems must develop effective communication and understand the interplay among agents in order to achieve goals. However, existing reinforcement learning (MARL) with methods lack evaluation metrics for information weights information-level modeling. This causes neglect aggregation of multiple messages, thereby significantly reducing policy efficiency. In this paper, we propose pluggable adaptive generative networks (PAGNet), a novel...
ABSTRACT Wogonin and wogonoside are derived from the traditional Chinese medicine Scutellaria baicalensis. Due to their various biological activities, research on properties has simulated great interest. In this work, we systematically theoretically studied intra‐ inter‐ interactions of wogonin wogonoside. For interactions, details were exhibited with help IRI, BO, LOL‐π. To predict inter‐interactions, results ESP, van der Waals potential, hydrogen hydrophobic shown. Our meaningful will...
Abstract DNA three‐way junctions (TWJ‐DNA) are intermediate structures in replication and/or recombination. They play very important roles biological processes, but more subtle functions still unknown due partially to the lack of a fluorescent ligand. In this study, cationic calix[3]carbazole ( 2 ) has been synthesized and its properties interacting with TWJ‐DNA have evaluated by UV/Vis fluorescence spectroscopy, circular dichroism (CD), gel electrophoresis, 1 H NMR studies. The results show...