A5053260700- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Phytochemical compounds biological activities
- Inflammasome and immune disorders
- Circadian rhythm and melatonin
- Bladder and Urothelial Cancer Treatments
- Catalytic Processes in Materials Science
- Single-cell and spatial transcriptomics
- S100 Proteins and Annexins
- Organoselenium and organotellurium chemistry
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Catalysis and Oxidation Reactions
- Synthesis and Biological Activity
- Delphi Technique in Research
- Oral microbiology and periodontitis research
- Immune Cell Function and Interaction
- PARP inhibition in cancer therapy
- Cancer Cells and Metastasis
- Antimicrobial Peptides and Activities
- 14-3-3 protein interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Mechanisms and Therapy
Chongqing Medical University
2022-2025
Xuzhou University of Technology
2025
Southern Medical University
2024
Jilin University
2024
The translocation of an aryl group from selenium into carbon enabled by the cleavage C-Se bond is reported using nitrogen atom-linked 1,7-diynes and diaryl diselenides as starting materials, leading to various selenophene derivatives in a regioselective manner. This method enables construction two bonds C-C through sequential radical bicyclization 1,2-aryl migration under metal-free conditions. Control experiments mechanistic studies suggest that this reaction proceeds inert C(Ph)-Se bond,...
Ferroptosis is a novel form of programmed cell death that triggered by iron-dependent lipid peroxidation. Brusatol (BRU), natural nuclear factor erythroid 2-related 2 inhibitor, exhibits potent anticancer effects in various types cancer. However, the exact mechanism BRU treatment hepatocellular carcinoma (HCC) remains unknown. The HCC were detected using counting kit-8 and colony formation assays xenograft model. RNA sequencing (RNA-seq) bioinformatics analyses cells utilized to elucidate...
The aim of the research was to develop novel gallic acid (GA)-modified amphiphilic nanoparticles polyethylenimine (PEI)–polypropylene carbonate (PPC)–PEI (PEPE) and comprehensively assess its properties as an antiperiodontitis nanoparticle targeting Toll-like receptor (TLR). first step is evaluate binding potential GA core trigger receptors TLR2 TLR4/MD2 for periodontitis using molecular docking techniques. Following this, we conducted NMR, transmission electron microscopy, dynamic light...
Background: Osteoarthritis (OA) is a common joint disease with long-term pain and dysfunction that negatively affects the quality of life patients. Neutrophil extracellular traps (NETs), consisting DNA, proteins cytoplasm, are released by neutrophils play an important role in variety diseases. However, relationship between OA NETs unclear. Methods: In our study, we used bioinformatics to explore potential biological markers. GSE55235, GSE55457, GSE117999 GSE98918 were downloaded from Gene...
The interaction between T cells, particularly naïve CD4 cells (CD4Tn), and colorectal cancer (CRC) is highly complex. CD4Tn play a crucial role in modulating immune responses within the tumor microenvironment, yet precise mechanisms by which they influence progression remain elusive. This study aims to explore relationship CRC CD4Tn, identify biomarkers therapeutic targets, focus on of shaping environment CRC. Single-cell transcriptomics, alongside scPagwas algorithm, were employed pivotal...
Brusatol (BRU) is an important compound extracted from Brucea javanica oil, whose pharmacological effects are able to induce a series of biological effects, including inhibition tumor cell growth, anti‐inflammatory, antiviral, and antitumor. Currently, there so few studies about the brusatol on colorectal cancer that its anticancer mechanism has not been clearly defined. In this study, we made in‐depth investigation into effect towards proliferation metastasis colon possible mechanism. The...
Berberine hydrochloride (BBR) could inhibit the proliferation, migration, and invasion of various cancer cells. As only enzyme for de novo synthesis ribonucleotides, RRM2 is closely related to development tumorigenesis. However, not much currently known about functional roles in breast (BRCA), whether BBR regulates migration BRCA cells by regulating expression remains be determined. We study effects on cell proliferation vitro tumorigenesis vivo using colony formation assays, EdU xenograft...
Objective The relationship between macrophages and the gut microbiota in patients with atherosclerosis remains poorly defined, effective biological markers are lacking. This study aims to elucidate interplay microbial communities macrophages, identify biomarkers associated destabilization of atherosclerotic plaques. goal is enhance our understanding underlying molecular pathways pave new avenues for diagnostic approaches therapeutic strategies disease. Methods employed Weighted Gene...
Due to poor prognosis and immunotherapy failure of skin cutaneous melanoma (SKCM), this study sought find necroptosis-related biomarkers predict improve the situation with predicted drugs.The Cancer Genome Atlas (TCGA) The Genotype-Tissue Expression Program (GTEx) database were utilized recognize differential genes (NRGs). Univariate Cox (uni-Cox) least absolute shrinkage selection operator (LASSO) analysis for prognostic signature establishment. was verified in internal cohort. To assess...
The objective is to create an IRGPI (Immune-related genes prognostic index), which could predict the survival and effectiveness of immune checkpoint inhibitor (ICI) treatment for lung adenocarcinoma (LUAD).By applying weighted gene co-expression network analysis (WGCNA), we ascertained 13 associated with functions. An was constructed using four through multicox regression, its validity assessed in GEO dataset. Next, explored immunological molecular attributes advantages ICI subcategories...
Circadian rhythm disruption impacts the efficiency of both chemotherapy and immunotherapy, yet identifying key factors involved remains challenging. can trigger aberrant fibroblasts activation, suggesting potential roles cancer-associated (CAFs) in addressing this issue. In paper, TCGA-BLCA patients were classified into two subgroups based on expression core circadian genes (CCRGs). The CCRG-based showed distinct fibroblast-related signals, from which a risk model composed five was finally...
To establish a pyroptosis-related gene (PRG) signature that could be utilized to predict hepatocellular carcinoma (HCC) survival and clinical features.The Cancer Genome Atlas (TCGA) database was identify differentially expressed PRGs. Univariate Cox least absolute shrinkage selection operator (LASSO) regression analyses were the prognostic signature. The verified in International Consortium cohort (ID: LIHC-US). Based on medium-risk score, HCC samples classified into high- or low-risk...
To investigate the injury of cyanate on pulmonary function and morphology C57/BL6N mice.Forty male mice were randomly divided into two groups: normal control group (20 mice) mice). Mice exposed to 100 mmol/L feeding for 4 weeks, Raw (Resistance in Air Way) was measured at beginning end experiment. The sacrificed fourth week experiment, lung tissues collected pathological observation molecular detection E-Cadherin Fibronectin. Well-growing A549 cells logarithmic growth phase treated with...