A5100756370- Glioma Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Liver Disease Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Pediatric Hepatobiliary Diseases and Treatments
- Brain Metastases and Treatment
- Hematopoietic Stem Cell Transplantation
- Estrogen and related hormone effects
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Chronic Myeloid Leukemia Treatments
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Biliary and Gastrointestinal Fistulas
- Lung Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Liver physiology and pathology
- Nanoparticle-Based Drug Delivery
Second Affiliated Hospital of Xi'an Jiaotong University
2012-2025
Weifang People's Hospital
2025
Jilin University
2015-2024
First Hospital of Jilin University
2015-2024
Shanghai East Hospital
2015-2024
Tianjin Medical University Cancer Institute and Hospital
2014-2024
Third Affiliated Hospital of Southern Medical University
2024
Soochow University
2016-2024
Chongqing Academy of Animal Science
2024
Renji Hospital
2022-2023
Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as oncogenic driver in hematological malignancies and promotes tumor growth solid tumors. However, little is known about the mechanisms underlying activation of this proto-oncogene Immunohistochemical staining showed that FLI1 aberrantly overexpressed advanced stage metastatic breast cancers. Using a CRISPR Cas9-guided immunoprecipitation assay, we identify circular RNA promoter chromatin complex,...
In human and murine models of nonalcoholic steatohepatitis (NASH), increased hepatocyte apoptosis is a critical mechanism contributing to inflammation fibrogenesis. Caspase 8 (Casp8) essential for death-receptor-mediated activity therefore its modulation might be the pathogenesis NASH. The aim was dissect role Casp8 in model steatohepatitis. We generated hepatocyte-specific knockout (Casp8(Δhep) ) mice. Animals were fed with methionine-choline-deficient (MCD) diet. Liver injury assessed by...
The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety intrathecal chemotherapy (IC) combined concomitant involved‐field radiotherapy (IF‐RT) treating LM Fifty‐nine various were enrolled between May 2010 December 2014. Concurrent therapy consisted IC (methotrexate 12.5–15 mg dexamethasone 5 mg, weekly) IF‐RT (whole brain and/or spinal...
// Zhiyun Yu 1 , Gang Zhao Guifang Xie 2 Liyan 3 Yong Chen Hongquan Zhonghua Zhang Cai Li 4 Yunqian Department of Neurosurgery, First Hospital Jilin University, Changchun, China Obstetrics and Gynecology, Clinical Laboratory, Second Experimental Pharmacology Toxicology, School Pharmacy, Correspondence to: Li, e-mail: 664857729@qq.com Keywords: AMPK, AKT-mTOR, glioma stem cell, metformin, temozolomide Received: May 20, 2015 Accepted: September 14, Published: 26, ABSTRACT Glioblastoma (GBM) is...
Abstract Lessons Learned Background We conducted a phase Ib study of radiotherapy plus programmed cell death protein 1 (PD-1) monoclonal antibody camrelizumab as first-line treatment for locally advanced esophageal squamous carcinoma (ESCC). Methods planned to enroll 20 patients with newly diagnosed ESCC. Patients received 60 Gy radiation (2.0 Gy/fraction, 5 fractions/week), (200 mg every 2 weeks) starting and continuing 32 weeks (i.e., 16 cycles). The primary endpoints were safety...
Patients with locally advanced esophageal squamous cell carcinoma (ESCC) show poor survival after concurrent chemoradiotherapy. This study investigated the safety and feasibility of combining chemoradiotherapy anti-PD-1 antibody camrelizumab as first-line treatment for these patients. In this phase 1b (ClinicalTrials.gov NCT03671265), patients received chemotherapy (cisplatin [25 mg/m2] plus docetaxel 4 weeks) radiotherapy (2.0 Gy/fraction, total 60 Gy) (200 mg every 2 weeks 32 weeks)....
Abstract Ferroptosis, characterized by iron accumulation and lipid peroxidation (LPO), can avoid the intrinsic apoptotic resistance of tumor cells have been explored for glioblastoma (GBM) therapy. However, direct delivery species may trigger severe adverse side effects. Using nonferrous to induce LPO‐mediated ferroptosis maybe a promising strategy GBM treatment, but there is still no report till now. Therefore, in this study, first an intelligent blood–brain barrier (BBB)‐permeable...
The development of a radioresponsive delivery platform has led to an innovative combination radioimmunotherapy strategy for treating tumors. However, controlling the release immunomodulators by local radiotherapy in vivo remains significant challenge order minimize off-target toxicity, reduce radiation-induced immunosuppression, and maximize synergistic efficacy. In this study, we report core-cross-linked diselenide nanoparticles (dSeNPs) as carriers toll-like receptors 7/8 agonist through...
// Guangtong Zhou 1 , Xinrui Liu Yunqian Li Songbai Xu Chengyuan Ma Xinmin Wu Ye Cheng Zhiyun Yu Gang Zhao Yong Chen Department of Neurosurgery, First Hospital Jilin University, Changchun, China Correspondence to: Chen, e-mail: cy_9201982@aliyun.com Zhao, zhao_gangjlu@aliyun.com Keywords: telomere, G-quadruplex, telomerase, DNA damage, T-loop Received: August 19, 2015     Accepted: January 29, 2016     Published: February 18, 2016 ABSTRACT Interference...
AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I II clinical trials for treatment of several cancers. However, mechanisms by which targets kills glioma cells tissues remain unclear. Here we report that induces cell apoptosis cycle arrest, inhibits viability up-regulation p53 down-regulation Bcl-2 Akt1 in human cells. NCL was overexpressed both nucleus cytoplasm U87, U251 SHG44 compared normal astrocytes (NHA). bound inhibited proliferation but not...
In this study, we examined the characteristics and aimed to increase knowledge of clinical features leptomeningeal metastasis (LM). The data, including initial diagnosis treatment primary tumor, manifestations, neuroimaging findings, cerebrospinal fluid (CSF) examination, were analyzed. For patients with adenocarcinoma/breast cancer, incidence cranial lesions nerve paralysis was obviously higher than small cell lung cancer. Whereas, involvement intravertebral canal lower that Patients cancer...
Abstract Romidepsin (FK228), a histone deacetylase inhibitor (HDACi), has anti-tumor effects against several types of solid tumors. Studies have suggested that HDACi could upregulate PD-L1 expression in tumor cells and change the state immune responses vivo. However, influence enhanced induced by romidepsin on is still under debate. So, purpose this study was to explore colon cancer. The results indicated inhibited proliferation, G0/G1 cell cycle arrest increased apoptosis CT26 MC38 cells....
Background The first clinical study (NCT03671265) of first-line chemoradiotherapy combined with PD-1 blockade showed promising treatment outcomes in locally advanced esophageal squamous cell carcinoma (ESCC). However, partial patients did not respond to the combination treatment. roles dendritic cells (DCs) and macrophages this remain poorly understood. Methods We performed multiplexed immunofluorescence method identify CD11c + DCs, CD68 macrophages, their PD-L1 - or subpopulations paired...
Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study was compare the efficacy 100 mg rectal versus on PEP incidences. This multicentre, double-blinded, randomised controlled trial conducted nine tertiary centres China. Patients with low and high risk for native papilla were randomly allocated (1:1) receive or rectally before ERCP. primary outcome occurrence...
Exercise can increase skeletal muscle sensitivity to insulin, improve insulin resistance and regulate glucose homeostasis in rat models of type 2 diabetes. However, the potential mechanism remains poorly understood. In this study, we established a male Sprague–Dawley model diabetes, with β cell dysfunction, which was induced by high-fat diet low-dose streptozotocin replicate pathogenesis metabolic characteristics diabetes humans. We also investigated possible chronic acute exercise improves...
// Feng Li 1,2 , Zhichao Liao Jun Zhao Gang 2,3 Xubin 2,4 Xiaoling Du 5 Yun Yang and Jilong 1 Department of Bone Soft Tissue Tumor, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People's Republic China 2 National Clinical Research Center Cancer, 3 Pathology, 4 Radiology, Diagnostics, University, Correspondence to: Yang, email: Keywords : sarcoma; Apatinib; efficacy; progression free survival; clinical benefit response Received October 06, 2016 Accepted March 01, 2017...
Intrauterine adhesions (IUA) are a significant cause of menstrual disturbance and infertility, but their pathogenesis still remains unclear. Here, we investigated the expression TGF-β CCN2 in IUA endometrial tissue by immunohistochemistry, western blotting qRT-PCR assays, found was significantly increased compared to normal endometrium uterine septum (P<0.01), suggesting that may play an important role formation IUA. Moreover, activity NF-κB signaling pathway also enhanced (P<0.01)...