A5055054623- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Cancer, Lipids, and Metabolism
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cell Image Analysis Techniques
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Ginseng Biological Effects and Applications
- Phytochemical compounds biological activities
- Protein Tyrosine Phosphatases
- Curcumin's Biomedical Applications
- Telomeres, Telomerase, and Senescence
- Peptidase Inhibition and Analysis
- Multiple Myeloma Research and Treatments
Guangxi Normal University
2025
University of Science and Technology of China
2025
Sun Yat-sen University Cancer Center
2024-2025
Sun Yat-sen University
2024-2025
Zhongda Hospital Southeast University
2022-2025
Tianjin Medical University Cancer Institute and Hospital
2016-2024
State Key Laboratory of Oncology in South China
2024
Lishui City People's Hospital
2023
Soochow University
2020-2022
First Affiliated Hospital of Soochow University
2020-2022
Immunosuppressive phenotype compromised immunotherapy efficacy of hepatocellular carcinoma. Tumor cells intrinsic mitochondria dynamics could pass effects on the extracellular microenvironment through mtDNA stress. PGAM5 anchors at and regulates functions. We aim to explore whether regulation tumor-intrinsic affects tumor-infiltrating immune in can be a therapeutic target enhance carcinoma (HCC). analyzed correlation expression infiltration using Gene Expression Omnibus (GEO) The Cancer...
The anticancer drug camptothecin (CPT) was successfully in situ loaded into a hydrogen-bonded organic framework (HOF) by one-pot method with high loading efficiency of 42 wt%, and the resultant...
To investigate the effects of selenium nanoparticles (nano-Se) combined with radiotherapy on proliferation, migration, invasion, and apoptosis non-small cell lung cancer (NSCLC) A549 NCI-H23 cells.Nano-Se was synthesized characterized by transmission electron microscope (TEM), X-ray diffractometer, Ultraviolet-visible (UV)-Vis Spectroscopy, separately. The uptake nano-Se cells detected flow cytometry. Cell counting kit-8 (CCK-8) method used to detect antiproliferative activity radiotherapy....
PurposeTelomerase is reactivated in non-small cell lung cancer (NSCLC), and it increases resistance to irradiation through protecting damaged telomeres enhancing DNA damage repair. We investigated the radiosensitizing effect of BIBR1532, a highly selective telomerase inhibitor, its corresponding mechanism NSCLC.Methods MaterialsCell proliferation, activity, telomere dysfunction-induced foci were measured with CCK-8 assay, real-time fluorescent quantitative polymerase chain reaction,...
Background The first clinical study (NCT03671265) of first-line chemoradiotherapy combined with PD-1 blockade showed promising treatment outcomes in locally advanced esophageal squamous cell carcinoma (ESCC). However, partial patients did not respond to the combination treatment. roles dendritic cells (DCs) and macrophages this remain poorly understood. Methods We performed multiplexed immunofluorescence method identify CD11c + DCs, CD68 macrophages, their PD-L1 - or subpopulations paired...
T cell receptor (TCR) repertoire as a biomarker for predicting immunotherapy efficiency has been widely studied. However, its dynamics during radiotherapy combined with PD-1 blockade is little known. Using paired tumor and blood samples from the phase Ib clinical study (NCT03222440), we investigate time-spatial TCR in esophageal squamous carcinoma (ESCC) patients treated first-line definitive concurrently anti-PD-1 antibody camrelizumab, also evaluate association between outcomes. sequencing...
Homologous recombination deficiency (HRD) refers to the dysfunction of homologous repair (HRR) at cellular level. The assessment HRD status has important significance for formulation treatment plans, efficacy evaluation, and prognosis prediction patients with ovarian cancer. This study aimed construct a deep learning-based classifier identifying tumor regions from whole slide images (WSIs) stratify cancer (OC). learning models were trained on 205 H&E-stained sections which contained...
Doxorubicin is widely used in cancer treatment, and an effective drug carrier usually needed to overcome its serious side effects. In this study, highly monodisperse hollow covalent organic framework...
Objective: To examine the association between serum lipids, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C) and low-density (LDL-C), risk progression of breast cancer in postmenopausal premenopausal women. Methods: A review analysis female patients who underwent surgery blood lipid metabolism testing Tianjin One Hospital, from January 2013 to October 2013, was performed. 1 081 were included final analysis. The control group consisted 2 981 women without...
To investigate the relationship between baseline nutrition status and radiation esophagitis in patients with esophageal cancer treated by therapy.A retrospective study was performed on 100 who definitive chemoradiotherapy, preoperative chemoradiation radiotherapy at Tianjin Medical University Cancer Institute Hospital from October 2018 2019. We documented clinical characteristics of patients, including tumor location, stage, treatment, dose, gross volume (GTV), planning (PTV) Atkinson's...
The systematic immune status of cancer patients undergoing immunotherapy is little known. We prospectively identified the function and differentiation traits peripheral CD8+ T cells based on our phase 1b clinical trial (NCT03222440) radiotherapy combined with camrelizumab in locally advanced esophageal squamous cell carcinoma (ESCC) compared it concurrent chemoradiotherapy (CCRT). 19 18 were included cohort plus CCRT treatment. By using flow cytometry, we evaluated expression levels PD-1,...
Acute kidney injury (AKI) is a critical clinical disease characterized by an acute decrease in renal function. Long non-coding RNAs (LncRNAs) are important AKI. This study aimed to explore the mechanism of lncRNA Kcnq1ot1 AKI sponging microRNA (miR)-204-5p as competitive endogenous RNA (ceRNA). mouse model and hypoxia/reoxygenation (H/R) human (HK) cells were established. expression, cell proliferation, apoptosis measured. Binding relations among Kcnq1ot1, miR-204-5p, NLRP3 verified....
Abstract Despite the widely recognition of K-ras oncogenic role, underlying biochemical pathways and metabolic regulation that promote cancer development remain to be characterized. Here we show SQLE, a key enzyme in cholesterol synthesis, is upregulated by its expression levels are closely correlated with poor prognosis pancreatic patients. Mechanistically, SQLE essential for timely removal endogenous squalene, which at high concentration inhibits PGC-1α-mediate mitochondrial biogenesis via...
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small cell lung cancer (NSCLC) with poor prognosis. The skipping mutation in exon 14 MET, an oncogenic driver NSCLC, occurs more frequently PSC than other subtypes. Treatment options for patients include targeted therapies and immunotherapies, while the best treatment regimen has not been established due to limited number patients. In this report, we presented case metastatic harboring MET mutation. patient received crizotinib...
Abstract Our previous phase Ib trial (NCT03222440) showed that radiotherapy plus the anti–PD-1 antibody camrelizumab is a safe and feasible first-line therapy for locally advanced esophageal squamous cell carcinoma. In this study, we divided peripheral CD8 T-cell differentiation subsets into 4 subpopulations (naive T cells, central memory effector CD45RA+ cells). We then investigated influence of on proportions their PD-1, TIGIT, CTLA-4 expression as well proliferative activity compared...
There is no remedial strategy other than definitive chemoradiotherapy for patients with advanced esophageal squamous cell carcinoma (ESCC) who are not eligible to undergo surgical treatment.To introduce a novel therapy called endoscopic debulking resection (EdR) followed by additive (CRT) and evaluate its efficacy safety.Advanced, inoperable ESCC between 1 January 2015 30 December 2019 were investigated retrospectively. Patients received EdR CRT deemed the + group those without group....
Compelling research to explore the effectiveness of simultaneous integrated dose reduction in clinical target volume (CTV) with intensity-modulated radiotherapy (SIR-IMRT) for locally advanced esophageal squamous cell carcinoma (ESCC) are limited. This study aimed compare efficacy and treatment-related toxicity between SIR-IMRT conventional IMRT (C-IMRT) treatment ESCC.From March 2010 September 2016, data 257 patients ESCC who received definitive Tianjin Medical University Cancer Institute...