A5100664723- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
- Brain Metastases and Treatment
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- Head and Neck Cancer Studies
- Gestational Trophoblastic Disease Studies
- Mesenchymal stem cell research
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Pleural and Pulmonary Diseases
- Respiratory viral infections research
- Nerve injury and regeneration
- Hip and Femur Fractures
- Effects of Radiation Exposure
- Influenza Virus Research Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Tianjin Medical University Cancer Institute and Hospital
2015-2023
Center for Cancer Research
2020
National Clinical Research
2015
Tianjin Medical University
2014
Institute of Microbiology
2009
Academy of Military Medical Sciences
2009
Abstract Lessons Learned Background We conducted a phase Ib study of radiotherapy plus programmed cell death protein 1 (PD-1) monoclonal antibody camrelizumab as first-line treatment for locally advanced esophageal squamous carcinoma (ESCC). Methods planned to enroll 20 patients with newly diagnosed ESCC. Patients received 60 Gy radiation (2.0 Gy/fraction, 5 fractions/week), (200 mg every 2 weeks) starting and continuing 32 weeks (i.e., 16 cycles). The primary endpoints were safety...
Abstract Objective The purpose of this study is to verify the correlation between medium and low radiation doses pelvic-bone marrow incidence lymphocytic toxicity during concurrent chemoradiotherapy for cervical cancer. Materials methods This research included 117 cancer patients, who received chemoradiotherapy. Radiotherapy external-beam therapy brachytherapy. dosimetry parameters include Volume receiving 5 Gy (V5), 10 (V10), 20 (V20), 30 (V30), 40 (V40), 50 (V50), mean dose (D mean) bone...
Clinical tools are unavailable for accurate prediction of pathologic responses to chemoradiation therapy (CRT) among patients with esophageal squamous cell carcinoma (ESCC) before surgery. We evaluated tumor remission and tumor-infiltrating lymphocytes (TILs) during CRT as predictors response prognostic markers locally advanced ESCC treated neoadjuvant (neo-CRT) or definitive CRT.We analyzed (N = 164) who underwent neo-CRT 48) 116). Patients endoscopic ultrasonography biopsies when induction...
In this retrospective study, we developed nomograms for predicting the efficacy of post-operation radiotherapy (PORT) in IIIA-N2 non-small cell lung cancer (NSCLC) patients. total, 334 patients received post-operational chemotherapy and were included analysis. Of those, 115 also either concurrent or sequential (PORT). Nomograms using Cox proportional hazard regression models to identify clinicopathological characteristics that predicted progression free survival (PFS) overall (OS), subgroup...
To evaluate the clinical outcomes of simultaneous dose reduction elective nodal area with intensity-modulated radiotherapy (SIR-IMRT) versus conventional IMRT (C-IMRT) in patients limited-stage small-cell lung cancer (LS-SCLC), LS-SCLC who received definitive SIR-IMRT or C-IMRT were retrospectively analyzed. In group, prescribed was 60Gy to planning gross target volume (PTVG), and 54Gy (PTV). whole PTV. Radiation-related toxicities estimated according Common Terminology Criteria for Adverse...
Objective: The use of postoperative radiotherapy (PORT) remains controversial for Stage IIIA-N2 non-small-cell lung cancer (NSCLC) patients, a possible reason is that IIIA-pN2 NSCLC diseases are heterogeneous group with different clinicopathologic features. aim this research was to prove whether the mediastinal lymph nodes' (LNs) skipping status could indicate necessity PORT pN2 patients. Methods: skip metastasis defined as pN0N2 (no N1 LN involved), and nonskip pN1N2 (one or more LNs...
Reappraisal of the role postoperative radiotherapy in pN2 non-small cell lung cancer (NSCLC) patients according to N1 lymph node involvement. A total 218 pIIIa-N2 NSCLC who underwent complete surgical resection with systematic nodal dissections were enrolled. Propensity scores used for matching Overall survival (OS) and disease-free (DFS) analyzed retrospectively. After matching, pN2b without involvement (pN0N2b) exhibited better prognoses than those (pN1N2b) (5-year OS: 37.5% vs. 7.1%, P =...
To investigate the short-term efficacy and radiotoxicity 3.543of chronoradiotherapy in patients with cervical cancer. We also examined overall symptom score quality of life (QOL) who underwent morning radiotherapy evening radiotherapy.We conducted a multicenter randomized controlled trial to compare effects (9:00-11:00 AM) (7:00-9:00 PM) cancer receiving radiotherapy. From November 2021 June 2022, 114 admitted eight center hospitals Tianjin, Chongqing, Hubei, Shanxi, Shandong, Shaanxi,...
Radiotherapy is the major approach and well tolerated in locally advanced esophageal squamous cell carcinoma (ESCC).And nowadays, no effective biological markers have been identified for predicting prognosis of patients with ESCC.Platelet-derived growth factor (PDGF) associated a poor various malignancies.The present study aimed to assess effect PDGF-BB on radiotherapeutic responses ESCC underlying mechanisms its roles ESCC.Serum from 68 cases that received neoadjuvant or radical...
To evaluate and analyze the efficacy prognostic factors of intensity-modulated radiotherapy in 250 patients with cervical upper esophageal carcinoma.From September 2009 to 2016, we retrospectively analyzed carcinoma treated (IMRT). In our study, all received IMRT, 54 196 carcinoma. Treatment response, survival status failure modes treatment were observed, analyzed.The median time was 22.60 months 3-year rate 42%. The progress-free 14.52 29.3%. for 20.40 15.15 months, respectively. 25.80...
This study aimed to analyze the prognostic significance of positive nodal chain ratio (NCR) in non-small-cell lung cancer (NSCLC). A total 208 pIIIa-N2 NSCLC patients who underwent complete surgical resections with a systematic dissection were enrolled. The median values NCR and lymph node (LNR) used grouping patients. differences overall survival (OS) disease-free (DFS) between different groups compared. LNR 0.31 0.45, respectively. separated into group (NCR ≤0.45 ≤0.31; 91 cases), B >0.31...
The aim of the study was to compare clinical outcomes induction chemotherapy (IC) followed by definitive concurrent chemoradiotherapy (dCCRT) versus alone in patients with esophageal squamous cell carcinoma (ESCC) on basis a scoring model.A retrospective review 599 ESCC treated dCCRT at our institution from 2010 2019 conducted. were divided into two groups based whether they received IC. A model performed using significant variables obtained multivariate analysis. PFS and OS rates estimated...
Objective To investigate the impact of postoperative radiotherapy (PORT) on prognosis early-stage small-cell lung cancer (SCLC). Methods The clinical data 71 patients who were clinically diagnosed with stage T1-2N0M0 SCLC and underwent radical resection surgery in our hospital from 1997 to 2010 retrospectively analyzed. Thirty-one received PORT, fifty-five preoperative or chemotherapy. The locoregional recurrence (LRR), distant metastasis, overall survival (OS) rates calculated using...
e13024 Background: Previous researches indicated the enhanced radiosensitivity in HER2-positive cancer cells by pyrotinib. For patients with treatment-naive brain metastases and central nervous system (CNS) symptoms, whether radiotherapy (current mainstay treatment) combined pyrotinib-based systemic regimen is more beneficial remains unclear. This study explored pyrotinib plus capecitabine this population. Methods: In exploratory trial (NCT04767828), aged 18-75 years who had metastatic...
Abstract Objective The eighth edition of the American Joint Committee on Cancer/Union International Cancer Control esophageal cancer staging system was proposed in early 2018. includes clinical staging, pathological and neoadjuvant which fills blank non‐operative cancer. However, there are few reports purpose present study to verify prognostic value new for patients who undergo radical radiation therapy. Methods A total 544 with from Tianjin Medical University Institute Hospital between...
Abstract Background: The purpose of this study was to verify the radiation dose pelvic bone marrow different anatomical bony sitesand incidence neutrophil toxicity during concurrent chemoradiotherapy for cervical cancer. Methods: There were 117 cancer patients who received included in research. radiotherapy includedexternal-beam therapy (EBRT) and brachytherapy. dosimetric parameters V5, V10, V20, V30, V40, V50, Dmean. final count defined as lowest after 2 circles chemotherapy, or within 1...