A5021292004- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Gastroesophageal reflux and treatments
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Crystallization and Solubility Studies
- Gut microbiota and health
- Cytomegalovirus and herpesvirus research
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Alcohol Consumption and Health Effects
- Cancer Mechanisms and Therapy
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- MicroRNA in disease regulation
- Adolescent and Pediatric Healthcare
- Biliary and Gastrointestinal Fistulas
Second Affiliated Hospital of Xi'an Jiaotong University
2018-2025
Shaanxi Blood Center
2024
Shaanxi Provincial People's Hospital
2024
Xi'an Jiaotong University
2023
The University of Texas MD Anderson Cancer Center
2020
Shenzhen Center for Disease Control and Prevention
2011
Background Previous studies have shown inconsistent findings regarding the association of alcohol consumption with sarcopenia. Therefore, this study comprehensively investigated sarcopenia in a nationally representative sample US adults. Methods This population-based included adults aged 18 years and older from National Health Nutrition Examination Survey (NHANES) III. Alcohol exposure was defined as daily intake, drinking history, number days per week, frequency binge month. Weighted...
Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study was compare the efficacy 100 mg rectal versus on PEP incidences. This multicentre, double-blinded, randomised controlled trial conducted nine tertiary centres China. Patients with low and high risk for native papilla were randomly allocated (1:1) receive or rectally before ERCP. primary outcome occurrence...
Hepatocellular carcinoma (HCC) is a common abdominal cancer with dissatisfactory therapeutic effects. The discovery of cuproptosis lights on new approach for treatment and assessment. So far, there extremely limited research investigating the roles cuproptosis-related (CR) genes in cancers.A novel CR risk signature was constructed using Lasso regression analysis. Its prognostic value assessed via series survival analyses validated three GEO cohorts. effects tumor immune microenvironment...
BACKGROUNDAcute variceal bleeding is one of the deadliest complications cirrhosis, with a high risk in-hospital rebleeding and mortality.Some scoring systems to predict clinical outcomes in patients upper gastrointestinal have been developed.However, for cirrhotic bleeding, data regarding predictive value these prognostic scores predicting are limited controversial. AIMTo validate compare overall performance selected bleeding. METHODSFrom March 2017 June 2019, acute were retrospectively...
Acute bleeding due to esophageal varices (EVs) is a life-threatening complication in patients with cirrhosis. The diagnosis of EVs mainly through upper gastrointestinal endoscopy, but the discomfort, contraindications and complications endoscopic screening reduce patient compliance. According risk EVs, Baveno VI consensus divides into high (HEVs) low (LEVs). We sought identify non-invasive prediction model based on spleen stiffness measurement (SSM) liver (LSM) as an alternative screening.To...
Abstract Lysyl‐oxidase‐like 3 (LOXL3) was reported to be essential in epithelial‐mesenchymal transition (EMT) of cancers. However, the role LOXL3 hepatocellular carcinoma (HCC) remained unclear. In this study, we explored clinical significance, biological functions, and regulatory mechanisms HCC. Our study found that expression markedly associated with tumor size stage HCC, it highly expressed tissues metastatic HCC patients. High predicted a poor prognosis TGF‐β1 treatment elevated protein...
Abstract Irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder, is recognized for its association with alterations in the gut microbiome and metabolome. This study delves into largely unexplored domain of virome IBS patients. We conducted comprehensive analysis fecal metagenomic data set from 277 patients 84 healthy controls to characterize viral community. Our findings revealed distinct compared individuals, marked by significant variances between‐sample diversity...
Abstract Hepatic ischemia‐reperfusion (IR) injury is a complex systemic process causing series clinical problem. C/EBPα key transcription factor for hepatocyte function, but its role and mechanism in regulating hepatic IR are largely unknown. Occluding portal vein artery was used to establish mouse model of injury. expression decreased IR‐injured liver compared with the sham, accompanied by increased contents serum alanine transaminase (ALT), aspartate (AST), high mobility group box‐1,...
Endoplasmic reticulum stress (ERS) and unfolded protein response are the critical processes of tumour biology. However, roles ERS regulatory genes in pancreatic adenocarcinoma (PAAD) remain elusive. A novel ERS-related risk signature was constructed using Lasso regression analysis. Its prognostic value, immune effect, metabolic influence, mutational feature therapeutic correlation were comprehensively analysed through multiple bioinformatic approaches. The biofunctions KDELR3 YWHAZ cancer...
Pancreatic cancer (PC) is a highly aggressive malignancy with poor prognosis, making early diagnosis crucial for improving patient outcomes. While the gut microbiome, including bacteria and viruses, believed to be essential in pathogenicity, potential contribution of virome PC remains largely unexplored. In this study, we conducted comparative analysis viral compositional functional profiles between patients healthy controls, based on fecal metagenomes from two publicly available data sets...
Rationale: Chronic kidney disease (CKD) is a progressively debilitating condition leading to dysfunction and severe complications. While dysbiosis of the gut bacteriome has been linked CKD, alteration in viral community its role CKD remain poorly understood. Methods: Here, we characterize virome using metagenome-wide analyses faecal samples from 425 patients 290 healthy individuals. Results: associated with remarkable shift profile that occurs regardless host properties, stage, underlying...
There are two types of esophageal varices (EVs): high-risk EVs (HEVs) and low-risk EVs, HEVs pose a greater threat to patient life than EVs. The diagnosis is mainly conducted by gastroscopy, which can cause discomfort patients, or non-invasive prediction models. A number models for predicting have been reported; however, those that based on the formula calculation liver spleen volume in not reported.To establish model patients with viral cirrhosis.Data from 86 EV cirrhosis were collected....
<b><i>Introduction:</i></b> The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) with renal insufficiency in recent years and the association between MAFLD are not entirely clear, especially overweight/obesity. aim this study was to analyze risk factors overweight/obese adults. <b><i>Methods:</i></b> Individuals who attended checkup at Second Affiliated Hospital Xi’an Jiaotong University from 2016 2021 were included....
Patients with inflammatory bowel disease are at high risk for opportunistic infections, and fungal infections relatively uncommon among various infections.This case is the first reported ulcerative colitis accompanied Cryptococcus neoformans infection after infliximab treatment. In course of disease, patients had a variety including viruses, fungi bacteria.This highlights importance paying continued attention to disease.
This study characterized the concentration-time profile of melamine in heart, liver, spleen, lungs, kidneys, bladder, feces, urine, and plasma after (MM) administration. Female Sprague-Dawley rats received a single oral dose 1.0 g/kg body weight. Samples (n = 4 per time point) were collected at 12, 24, 48, 72, 96, 120, 144, 168 h. Based on calculations area under curves dosing, ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) was used to detect MM concentration...