A5101997485- Effects and risks of endocrine disrupting chemicals
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Injury Epidemiology and Prevention
- Immune Response and Inflammation
- Health, Environment, Cognitive Aging
- Mercury impact and mitigation studies
- Toxic Organic Pollutants Impact
- Melamine detection and toxicity
- RNA modifications and cancer
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Computational Drug Discovery Methods
- Trace Elements in Health
- Carcinogens and Genotoxicity Assessment
- Heavy Metal Exposure and Toxicity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- Chromium effects and bioremediation
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Pesticide Exposure and Toxicity
- Bone health and treatments
- Clusterin in disease pathology
Qingdao University
2025
Ningbo No.6 Hospital
2025
Botswana Geoscience Institute
2024
Kunming Medical University
2024
Yan'an Hospital Affiliated To Kunming Medical University
2024
Shenzhen Center for Disease Control and Prevention
2014-2023
Shanghai University of Traditional Chinese Medicine
2023
Xuzhou Medical College
2023
Shihezi University
2019-2023
Cancer Hospital of Shantou University Medical College
2023
Abstract Background Nanometer silicon dioxide (nano-SiO 2 ) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological proteomic effects nano-SiO exposure toxic mechanisms remain far from clear. Results Here, we evaluated amorphous (15-nm, 30-nm SiO ). on cellular viability, cycle, apoptosis protein expression HaCaT cells by using biochemical morphological analysis, two-dimensional differential gel electrophoresis (2D-DIGE) as...
Ischemic stroke (IS) is a major cause of morbidity and mortality globally. Environmental exposure to metals may be linked the risk IS, but association remains uncertain in Chinese populations. The present study aimed examine associations between concentrations 11 (aluminum, arsenic, cadmium, cobalt, copper, iron, manganese, molybdenum, selenium, thallium, zinc) plasma IS population. A total 1277 pairs newly diagnosed patients controls matched on age (±3 years) sex were recruited our study....
To evaluate the prevalence of abnormal vitamin B12, folate, total homocysteine (tHcy), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) levels, to analyze relationship between these parameters and severity anxiety or depressive symptoms, explore possible factors associated with levels in adolescents symptoms.Adolescent (aged 12-18 years) outpatients symptoms were recruited. The patient health questionnaire-9 generalized disorder scale-7 used measure depression...
Trichloroethylene-induced hypersensitivity dermatitis is one of the serious occupational health events in China, however, little known about clinical features and possible mechanism this disorder. The objective present study was to report some typical trichloroethylene-induced patients investigate their exposure as well features. We sampled tested cleaning agents from companies where TCE-induced skin disorder occurred, trichloroethylene concentrations were also monitored workplace air....
Circulating microRNAs (miRNAs) are emerging as novel disease biomarkers. Using a miRNA microarray, we previously showed that the whole blood level of let-7e-5p was significantly higher in ischemic stroke patients than control subjects. However, association between expression and occurrence remains unknown. In this study, validated levels two case-control populations using TaqMan assays further investigated potential targets let-7e-5p. The results suggest with controls (p<0.05). Higher were...
Exposure to phthalate esters may be linked the risk of high blood pressure (HBP), but limited evidence is available in Chinese children.To investigate associations between nine metabolites (mPAEs) and systolic/diastolic BP, pulse (PP), mean arterial (MAP), HBP.In this cross-sectional study, a total 1044 primary school children (6-8 years old) were enrolled from Shenzhen, China, 2016 2017. Nine mPAEs analyzed urine using ultra-performance liquid chromatography tandem mass spectrometry. A...
Chronic obstructive pulmonary disease (COPD) is a prevalent and progressive form of respiratory in which patients exhibit persistent damage affecting the alveoli and/or airway due to exposure toxic gases or particulate matter. C57BL/6 mice were exposed cigarette smoke lipopolysaccharide establish COPD model mice, followed by scATAC (Assay for Transposase Accessible Chromatin) sequencing scRNA lung tissue samples. The resultant data revealed consistent findings between scATAC-seq scRNA-seq...
Cyclist: individuals who ride bicycles as a mode of transportation or recreation. Cyclist Road Injuries (CRI): road traffic injuries sustained by cyclists, including collisions with motor vehicles, pedestrians, other well single-vehicle crash's (e.g., falls crashes without external collision). Detailed analyses the global burden CRI among youth and young adults aged 15-39 remain limited. This study evaluates disease from 1990 to 2021 using Global Burden Disease (GBD) data. Age-standardized...
The aim of our study was to explore the role nuclear factor erythroid 2 (NF-E2)-related (Nrf2) on exposure SiO2 nanoparticles (NPs) and its influence.To understand mechanism NP-induced oxidative stress, involvement oxidative-stress-responding transcription factors Nrf2/antioxidant reactive element (ARE) signaling pathway in toxicity NPs' investigated via vivo vitro models.A549 cells showed a significant cytotoxic effect while A549-shNrf2 decreased cell viability after nm-SiO2 exposure....
Alzheimer's disease (AD) is the most common age-related neurodegenerative threatening health of elderly, but available therapeutic and preventive drugs remain suboptimal. Loganin, an iridoid glycoside extracted from Cornus officinalis, reported to have anti-inflammatory memory-enhancing properties. This study aimed explore influence loganin on cognitive function in 3xTg-AD mice underlying mechanism associated with its neuroprotection. According results behavioral tests, we found that...
Abstract Context and Objective This case control study was designed to investigate the association between mutation of 10 single nucleotide polymorphism (SNP) loci (rs1132506, rs5780218, rs192636495, rs4889, rs184749, rs12985070, rs708910, rs932491, rs8074995, rs2306877) in all 5 genes (KISS1, GPR54, PLCB1, PRKCA, ITPR1) kisspeptin/GPR54 pathway risk early puberty Chinese Han girls. Design Participants A total 314 pairs girls on their first visit hospital age-matched controls (± 3 months)...