A5108155448- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- Viral Infections and Vectors
- Entomopathogenic Microorganisms in Pest Control
- Mosquito-borne diseases and control
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Plant Virus Research Studies
- Viral Infections and Outbreaks Research
- Advanced biosensing and bioanalysis techniques
- Invertebrate Immune Response Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Advancements in Transdermal Drug Delivery
- Animal Virus Infections Studies
- Water Systems and Optimization
- CRISPR and Genetic Engineering
- Corrosion Behavior and Inhibition
- Toxic Organic Pollutants Impact
- COVID-19 Clinical Research Studies
- Electrocatalysts for Energy Conversion
- Viral gastroenteritis research and epidemiology
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- COVID-19 and Mental Health
- Advanced Drug Delivery Systems
Chinese Academy of Sciences
2016-2025
Wuhan Institute of Virology
2016-2025
Hainan University
2024-2025
Beihua University
2013-2025
Xuzhou Medical College
2025
University of Science and Technology of China
2023-2024
Zhejiang A & F University
2023-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2022-2024
Sun Yat-sen University
2021-2024
Shanghai Institute of Materia Medica
2014-2024
Hyperuricemia, the physiological prerequisite for gout, is linked to presence and severity of multiple comorbidities that affect longevity well-being. By using baseline data from China Health Retirement Longitudinal Study, a nationally representative survey, prevalence hyperuricemia in general middle-aged older Chinese was estimated. The potential effects health behaviours on were also explored. In 2010, among 6.4%. Hyperuricemia more prevalent males than females (7.9% vs. 4.9%). risk...
The discovery of novel drug candidates with anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) potential is critical for the control global COVID-19 pandemic. Artemisinin, an old antimalarial derived from Chinese herbs, has saved millions lives. Artemisinins are a cluster artemisinin-related drugs developed treatment malaria and have been reported to multiple pharmacological activities, including anticancer, antiviral, immune modulation. Considering broad-spectrum antiviral...
Nanoplastics (NPs), as emerging pollutants, have attracted global attention. Nevertheless, the adverse effects of NPs on female reproductive health, especially unexplained miscarriage, are poorly understood. Defects trophoblast cell migration and invasion associated with miscarriage. Migrasomes were identified cellular organelles largely unidentified functions. Whether might affect migration, invasion, migrasome formation induce miscarriage has been completely unexplored. In this study, we...
Abstract Background With rapid increase in the global use of various plastics, microplastics (MPs) and nanoplastics (NPs) pollution their adverse health effects have attracted attention. MPs been detected out human body both NPs showed female reproductive toxicological animal models. Miscarriage (abnormal early embryo loss), accounting for 15-25% pregnant women worldwide, greatly harms reproduction. However, on miscarriage never explored. Results In this study, we identified that polystyrene...
Defects of human trophoblast cells may induce miscarriage (abnormal early embryo loss), which is generally regulated by lncRNAs. Ferroptosis a newly identified iron-dependent programmed cell death. Hypoxia an important and unavoidable feature in mammalian cells. However, whether hypoxia might ferroptosis then miscarriage, as well lncRNA, was completely unknown. In this work, we discovered at the first time that could result miscarriage. We also novel lncRNA (lnc-HZ06) simultaneously...
Abstract In the context of smart city development and rapid urbanization worldwide, urban water supply system (UWSS) has been vital importance to this process. This paper presents a comprehensive review on transient flow research for UWSS management. consists two aspects as follows. The first aspect is about progress current theory, including models, unsteady friction turbulence numerical simulation methods. other utilization application transient-based methods effective diagnosis...
The type I interferon (IFN) system, including IFN induction and signaling, is the critical component of host defense line against viral infection, which, in turn, also a vulnerable target for immune evasion. Severe fever with thrombocytopenia syndrome virus (SFTSV) an emerging bunyavirus. Previous data have shown that SFTSV can interfere early IFNs through targeting kinases TBK1/IKKε. In this study, we demonstrated suppress IFN-triggered signaling interferon-stimulated gene (ISG) expression....
For antiviral signaling mediated by retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), the recruitment of cytosolic RLRs and downstream molecules (such as TBK1 IKKε) to mitochondrial platform is a central event that facilitates establishment host state. Here, we present an example viral targeting for immune evasion through spatial isolation TBK1/IKKε from platform, which was employed severe fever with thrombocytopenia syndrome virus (SFTSV), deadly bunyavirus emerging recently. We...
Objectives . Infectious disease knowledge and behaviors are key elements that ensure student health safety. This study explores the impact of education on toward infectious diseases determines factors affecting among students in Gansu, China. Methods A cross-sectional three sampling methods were used two counties, 12 schools, 32 classes China, from 2012 to 2013. Collected data included following: (1) sociodemographic characteristics 2002 (1001 participants intervention group 1001 control...
The application of pressure-sensitive adhesives (PSAs) in transdermal drug delivery systems (TDDSs) is limited. Insufficient cohesion TDDS can lead to cold flow, patch displacement, dose inaccuracies, and the 'dark ring' phenomenon. To address these issues, we developed a semi-interpenetrating network (semi-IPN) PSA using 2-hydroxyethylacrylate-modified acrylic copolymer as linear polymer poly[tri(propylene glycol) diacrylate] cross-linked network. Semi-IPN PSAs have better mechanical...
Objectives: This study aimed to identify and develop a novel, safe, effective transdermal penetration enhancer derived from the leaves of Perilla frutescens (L.) Britt, explore underlying mechanisms its enhancement effects. Methods: To evaluate safety profile enhancer, both skin irritation tests histopathological analyses were conducted. The capabilities assessed in vitro using five model drugs. Furthermore, gain insights into mechanism this novel range analytical methods used, including...
Men's active involvement in reproductive healthcare has shown to be positively associated with maternal and child health outcomes. Bangladesh made appreciable progress its pursuance of mortality related goals the framework MDGs. However, there remains a lot accomplished realise long-term for which participation male counterparts care is crucial. Therefore, objective present study was investigate factors among Bangladeshi men.We used data from Demographic Health Survey (BDHS) conducted 2011....
The rapid emergence and spread of escaping mutations severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has significantly challenged our efforts in fighting against the COVID-19 pandemic. A broadly neutralizing reagent these concerning variants is thus highly desirable for prophylactic therapeutic treatments SARS-CoV-2 infection. We herein report a covalent engineering strategy on protein minibinders potent neutralization such as B.1.617.2 (Delta), B.1.617.1 (Kappa), B.1.1.529...
Exploring effective and robust strategies for enhancing electrochemiluminescence (ECL) emissions of porphyrin-based metal–organic frameworks (MOFs) is great importance expanding their applications in bioassays. Herein, a simple, convenient, endogenous strategy post-synthesis-modified Zn2+ was proposed to enhance ECL nonmetal MOFs. The porphyrin-cobuilt UiO-66-NH2 (TCPP/UiO-66-NH2), PCN-224, PCN-222, Ce–TCPP–LMOF could be enhanced 31.9, 47.1, 49.9, 19.2 times, respectively. By studying...
Abstract Human trophoblast cells are crucial for healthy pregnancy. However, whether the defective homologous recombination (HR) repair of dsDNA break (DSB) in may induce miscarriage is completely unknown. Moreover, abundance BRCA1 (a protein HR repair), its recruitment to DSB foci, and epigenetic regulatory mechanisms, also fully unexplored. In this work, it identified that a novel lnc‐HZ10, which highly experssed villous tissues recurrent (RM) vs their control group, suppresses cell....
Baculoviridae is a family of large DNA viruses that infect insects. They have been extensively used as safe and efficient biological agents for the control insect pests. As result coevolution with their hosts, baculoviruses developed unique life cycles characterized by production two distinctive virion phenotypes, occlusion-derived virus budded virus, which are responsible mediating primary infection in midgut epithelia spreading systemic within infected insects, respectively. In this...