A5114778102- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Gene Regulatory Network Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related Molecular Pathways
- DNA and Biological Computing
- Genomics and Chromatin Dynamics
- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- Phase Change Materials Research
- User Authentication and Security Systems
- Clusterin in disease pathology
- Postharvest Quality and Shelf Life Management
- Neural dynamics and brain function
- Genomics, phytochemicals, and oxidative stress
- Sleep and Wakefulness Research
- Wireless Communication Security Techniques
- bioluminescence and chemiluminescence research
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Carcinogens and Genotoxicity Assessment
Minzu University of China
2024
Chengdu University of Traditional Chinese Medicine
2024
Fudan University
2024
West China Hospital of Sichuan University
2022-2023
Key Laboratory of Guangdong Province
2014-2023
Sichuan University
2022-2023
Nanjing Medical University
2023
South China Agricultural University
2023
Shanghai Jiao Tong University
2017-2022
Shenzhen Center for Disease Control and Prevention
2014-2022
Background: The treatment of critical-size bone defect is a great difficulty in orthopedics. Osteogenesis and angiogenesis are critical issue during the process repair remodeling. Mesenchymal stem cells (MSCs)-derived exosomes have same therapeutic effect to MSCs-based therapies. human umbilical cord MSCs-derived sEVs (hUC-MSCs-sEVs) on vascularized regeneration potential mechanism remains be investigated. Herein, we aimed explore hUC-MSCs-sEVs defect. Methods: To investigate osteogenesis...
Recent breakthroughs of cell phenotype reprogramming impose theoretical challenges on unravelling the complexity large circuits maintaining phenotypes coupled at many different epigenetic and gene regulation levels, quantitatively describing phenotypic transition dynamics. A popular picture proposed by Waddington views differentiation as a ball sliding down landscape with valleys corresponding to types separated ridges. Based theories dynamical systems, we establish novel 'epigenetic state...
Our previous observations indicated that extractable organic matter (EOM) from PM2.5 induced malformations in the heart of zebrafish embryos by activating AhR and inhibiting canonical Wnt/β-catenin signal pathway. As a nutritional factor, folic acid (FA) is reported to prevent cardiac defects during embryo development. Hence, we hypothesize FA may PM2.5-induced interfering with signaling pathways. results showed supplementation alleviated EOM-induced embryos, both inhibitor CH223191 Wnt...
Abstract Background The incidence rates of thyroid tumors and nodular goiter show an upward trend worldwide. There are limited reports on the risk perchlorate iodine tumors, but evidence from population studies is scarce, their impact function still uncertain. Therefore, objective this study was to investigate association with (NG), papillary microcarcinoma (PTMC), carcinoma (PTC) assess correlation between indicators. Methods A case–control consisting 184 pairs matched by gender age (±2...
SUMMARY Reactive oxygen species (ROS) have been emerging as a key regulator in plant organ abscission. However, the mechanism underlying regulation of ROS homeostasis abscission zone (AZ) is not completely established. Here, we report that DOF (DNA binding with one finger) transcription factor LcDOF5.6 can suppress litchi fruitlet through repressing accumulation AZ (FAZ). The expression LcRbohD , homolog Arabidopsis RBOHs are critical for production, was significantly increased during...
Molecular glues are typically small chemical molecules that act at the interface between a target protein and degradation machinery to trigger ternary complex formation. Identifying molecular is challenging. There scarcity of target-specific upregulating glues, which highly anticipated for numerous targets, including P53. P53 degraded in proteasomes through polyubiquitination by specific E3 ligases, whereas deubiquitinases (DUBs) remove conjugates counteract these ligases. Thus,...
Mitochondrial serine hydroxylmethyltransferase 2 (SHMT2) is a key enzyme in the serine/glycine synthesis pathway. SHMT2 has been implicated as critical component for tumor cell survival. The aim of present study was to evaluate prognostic value and efficiency biomarker patients with breast cancer. Individual pooled survival analyses were performed on five independent cancer microarray datasets. Gene signatures enriched by also analyzed these protein expression detected using...
Evaluating toxicity and decoding the underlying mechanisms of active compounds are crucial for drug development. In this study, we present an innovative, integrated approach that combines air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI), time-of-flight secondary ion (ToF-SIMS), spatial metabolomics to comprehensively investigate nephrotoxicity nitidine chloride (NC), a promising anti-tumor candidate. Our quantitive AFADESI-MSI analysis unveiled...
Objective: Inflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted response to inflammatory stimuli and oxidative stress, participating tissue or systemic inflammation. We investigated relationship between CypB MetS both humans mice. Methods: Serum levels were determined 211 subjects with 292 without (non-MetS) (133 healthy controls 159 high-risk one two components). Additionally, expression organs was examined...
Summary Enhancer of zeste 2 ( EZH 2), a polycomb histone methyltransferase, is overexpressed in various cancers, including cervical cancer. Gene expression analysis revealed that increased associated with cancer progression, particularly the progression to invasive squamous cell carcinoma. known trimethylate lysine 27 on H3, leading gene silencing contributes tumours into more aggressive form However, specific molecular mechanisms by which development remain largely unknown. Recently, an...
DNA damage repair is considered to be an important mechanism of cisplatin resistance, and the roles iron homeostasis in action mechanisms have not been studied yet. Herein, a Pt(IV) prodrug (DFX-Pt) integrating clinical oral iron-chelating agent deferasirox (DFX) found highly active toward cisplatin-insensitive triple-negative breast cancer cells both vitro vivo. RNA-sequencing shows that DFX-Pt can downregulate genes related double-strand break (DSB) pathway significantly. reduce cellular...
Abstract Mendelian genetics spark the century‐old revolution in genetic engineering. DNA structural engineering may well a similar chemistry. The first few man‐made structures are purely but increased interest hybrid with other molecules is regaining popularity. Nucleic acids can interact non‐nucleic acid‐based materials, showing their materialistic flexibility and potential prospect of forming new future materials. This review provides deep background based on interaction nucleic these...
Trichloroethylene (TCE), a common environmental contaminant, causes hepatocellular carcinoma in mice but not rats. To understand the mechanisms of species-specific hepatocarcinogenecity TCE, we examined methylation status DNA liver rats exposed to TCE at 0 or 1000 mg/kg b.w. for 5 days using MeDIP-chip, bisulfite sequencing, COBRA, and LC-MS/MS. The related mRNA expression levels were measured by qPCR. Although no global change was detected, 806 genes hypermethylated 186 hypomethylated. with...
Objectives The study aimed to investigate the effects of sleep and exercise, individually jointly, on depressive symptoms in Chinese adolescents. Methods Cluster sampling was used conduct a cross-sectional, electronic survey among 11,563 students from five primary high schools Sichuan Province Western China. questionnaire contained custom-designed items concerning while it Center for Epidemiologic Studies Depression Scale assess Core Self-Evaluations core self-evaluation. Data were analyzed...
Inflammatory factors have specific value in acute myocardial infarction (AMI). Our previous studies identified the prognostic of interleukin (IL)-34 during chronic heart failure. However, potential impact IL-34 on AMI remains unknown.Serum was measured 287 patients, and they were followed up for composite endpoint, including cardiovascular death, failure hospitalization, recurrent nonfatal (MI), stroke.IL-34 levels significantly associated with presence at baseline its aggravation after a...
Densely connected patterns in biological networks can help biologists to elucidate meaningful insights. How detect dense subgraphs effectively and quickly has been an urgent challenge recent years. In this paper, we proposed a local measure named the edge density coefficient, which could indicate whether locates subgraph or not. Simulation results showed that improve both accuracy speed detecting subgraphs. Thus, G-N algorithm be extended large by measure.