A5101420403- Pediatric Urology and Nephrology Studies
- Neonatal Respiratory Health Research
- Kidney Stones and Urolithiasis Treatments
- Ureteral procedures and complications
- Liver Disease Diagnosis and Treatment
- Neurobiology and Insect Physiology Research
- Cystic Fibrosis Research Advances
- Lymphatic System and Diseases
- Cancer Cells and Metastasis
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Immunotherapy and Immune Responses
- Insect and Arachnid Ecology and Behavior
- Diet, Metabolism, and Disease
- Chemokine receptors and signaling
- Insect Utilization and Effects
- Asthma and respiratory diseases
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Urological Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Thermoregulation and physiological responses
- Histone Deacetylase Inhibitors Research
University of Michigan
2021-2025
First Affiliated Hospital of Xinxiang Medical University
2025
First Affiliated Hospital of Gannan Medical University
2020-2025
People's Hospital of Cangzhou
2024
Hangzhou Red Cross Hospital
2024
Michigan Medicine
2024
Huazhong University of Science and Technology
2024
Huashan Hospital
2024
Fudan University
2024
Zhejiang Normal University
2022-2023
To compare the safety and efficacy of novel tip-flexible suctioning ureteral access sheath (NTFS-UAS) traditional (T-UAS) combined with flexible ureteroscope for treating unilateral renal calculi.The clinical data 214 patients calculi treated by NTFS-UAS (n = 102) T-UAS 112) from August 2021 to April 2022 were analyzed retrospectively. Demographic characteristics, stone-related parameters, operative time, stone-free rates (SFR), hospitalization time complication rate (CR) analyzed.No...
Metamorphosis in insects is regulated by juvenile hormone (JH) and ecdysteroids. The mechanism of 20-hydroxyecdysone (20E), but not JH action, well understood. A basic helix-loop-helix (bHLH)-Per-Arnt-Sim (PAS) family member, methoprene tolerant (Met), plays an important role action. Microarray analysis RNA interference (RNAi) were used to identify 69 genes that require Met for their hydroprene-regulated expression the red flour beetle, Tribolium castaneum. Quantitative real time PCR...
Juvenile hormones (JH) regulate a wide variety of developmental and physiological processes in insects. Comparison microarray data on JH-induced genes the fruit fly, Drosophila melanogaster, L57 cells honey bee, Apis mellifera, identified 16 that are induced both species. Analysis promoter regions these D. melanogaster DmJHRE1 (D. JH response element 1). In cells, reporter gene regulated by was III. Two proteins (FKBP39 Chd64) bind to were identified. FKBP39 Chd64 double-stranded RNA...
Abstract Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to not fully explained variation at robustly risk loci. To move towards saturation map susceptibility we meta-analysed 18 GWAS comprising 36,466 cases and 458,078 controls 109 distinct loci, 45 that been previously reported. These include variants loci in which...
Cystic fibrosis transmembrane conductance regulator gene (CFTR) expression in human airway epithelial cells involves the recruitment of distal cis-regulatory elements, which are associated with airway-selective DNase hypersensitive sites at -44 kb and -35 from gene. The -35-kb site encompasses an enhancer that is regulated by immune mediators interferon regulatory factor 1 2 nuclear Y. Here we investigate -44-kb element, also has activity vitro but inactive intestinal cells. This contains...
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by myofibroblast accumulation extracellular matrix deposition, which lead to irreversible damage of the lung’s architecture formation fibrotic lesions. IPF also sequela in serious patients with coronavirus 2019 (COVID-19). The molecular mechanisms under remain unclear, there no satisfactory treatment currently available. Piceatannol (PIC) naturally occurring resveratrol analog...
Molecular glues are typically small chemical molecules that act at the interface between a target protein and degradation machinery to trigger ternary complex formation. Identifying molecular is challenging. There scarcity of target-specific upregulating glues, which highly anticipated for numerous targets, including P53. P53 degraded in proteasomes through polyubiquitination by specific E3 ligases, whereas deubiquitinases (DUBs) remove conjugates counteract these ligases. Thus,...
The effect of the diurnal temperature range (DTR) on human health in diverse geographic areas and potential confounding factors are not fully understood. Additionally, while a robust association has been reported between cardiomyopathy (CM), evidence impact DTR is relatively limited. Here, we determined whether an exists CM hospitalisations vulnerable populations. admission data (2016-2021) were collected from seven tertiary hospitals Henan.We used GAM combined with distributed lag...
The low levels of CFTR gene expression and paucity protein in human airway epithelial cells are not easily reconciled with the pivotal role lung cystic fibrosis pathology. Previous data suggested that regulatory mechanisms controlling might be different epithelium comparison to intestinal where mRNA is much more abundant. Here we examine chromatin structure modification across locus primary tracheal (HTE) bronchial (NHBE) cell lines including 16HBE14o- Calu3. We identify regions open appear...
<title>Abstract</title> Inflammatory skin diseases (ISDs) exhibit varying prevalence across different ancestry background and geographical regions. Genetic research for complex ISDs has predominantly centered on European Ancestry (EurA) populations genetic effects immune cell responses but generally failed to consider contributions from other types in skin. Here, we utilized 273 signals seven ISDs: acne, alopecia areata (AA), atopic dermatitis (AD), psoriasis, systemic lupus erythematosus...
To evaluate the safety and efficacy of sotn ureteroscope system with vacuum suctioning device for treating complicated steinstrasse. The medical records 22 patients steinstrasse who underwent ureteroscopic lithotripsy via from January 2020 to March 2023 were summarized retrospectively. Five had ipsilateral renal calculi. 11.5/12.5 F ureteral access sheath (sotn-UAS) was placed below lowermost section assisted by a 7.5/9.8 standard ureteroscope, then 4.0/6.0 console laser fiber replaced used...
An airway-selective DNase-hypersensitive site (DHS) at kb -35 (DHS-35kb) 5' to the cystic fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell lines and primary human tracheal epithelial cells but absent from intestinal epithelia. The DHS-35kb contains an element with enhancer activity 16HBE14o- airway enriched for monomethylated H3K4 histones (H3K4me1). We now define a 350-bp region within which has full binds interferon regulatory factor 1 (IRF1) nuclear Y...
C-C chemokine receptor type 7 (CCR7) has been implicated in lymph node metastasis of various cancers. Previous studies have revealed that epithelial‑mesenchymal transition (EMT) is involved the chemotactic process mediated by CCR7 and its ligands types carcinoma. However, underlying mechanism this remains to be fully elucidated. The present study investigated whether (C‑C motif) ligand 21 (CCL21)/CCR7 may activate EMT lung cancer cells their associated signaling pathways. A549 H520 cell...
Nucleosome positioning on the chromatin strand plays a critical role in regulating accessibility of DNA to transcription factors and modifying enzymes. Hence, detailed information nucleosome depletion or movement at cis -acting regulatory elements has potential identify predicted binding sites for trans factors. Using novel method based enrichment mononucleosomal by bacterial artificial chromosome hybridization, we mapped positions deep sequencing across 250 kb, encompassing cystic fibrosis...
Multidrug resistance (MDR) of hepatocellular carcinoma is a serious problem. Although CD13 biomarker in human liver cancer stem cells, the relationship between and MDR remains uncertain. This study uses cell model to understand role enhancing cytotoxic effect chemotherapy agents. Cytotoxic agents can induce expression. inhibitor, bestatin, enhances antitumor Meanwhile, CD13-targeting siRNA neutralizing antibody enhance 5-fluorouracil (5FU). overexpression increases survival upon treatment,...
Abstract To present our experience with laparoscopic ureteroneocystostomy bladder flap (LUCBF) for treating benign ureteral stenosis and evaluate its feasibility efficacy. The clinical data of 27 patients who underwent LUCBF were retrospectively analyzed. After identification excision the segment, healthy stump was dissected incised longitudinally. A U-shaped or spiral harvested from anterolateral wall ureteroplasty. All successfully, including 14 combined psoas hitch technique, between 90...
Abstract Objective To analyze the risk factors associated with colorectal adenoma and to investigate associations of metabolism-related fatty liver disease (MAFLD) obesity, high-risk adenoma. Methods A total 1395 subjects were enrolled divided into a group (593 subjects) control (802 according inclusion exclusion criteria. The characteristics patients in compared by chi-square test. Univariate multivariate logistic analyses used independent different MAFLD subtypes. Colorectal proportion...
The aim of the present study was to investigate underlying mechanisms thymus‑expressed chemokine (TECK) autocrine signaling, and its effect on carcinogenesis development breast cancer. also assessed epithelial‑mensenchymal transition (EMT) cell migration, invasion, proliferation apoptosis. Breast cancer lines MCF‑7 MDA‑MB‑231 were used in study, TECK basic expression cells investigated using western blotting (WB). EMT markers, Akt pathway molecules apoptosis indicators detected by reverse...
Objectives We aimed to probe the safety and effectiveness of flexible ureteroscopic lithotripsy (FURL) with a suctioning ureteral access sheath (S-UAS) for removing upper urinary calculi under local anesthesia (LA). Materials methods The clinical data 56 patients treated by FURL an S-UAS LA during period between September 2019 November 2022 were analyzed retrospectively. For LA, intramuscular pethidine (1.0–2.0 mg/kg) phenergan (25 mg) administered 30 min prior surgery, oxybuprocaine...
Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety tumors. Many agonists have been reported to significant anticancer effects. Our previous studies found introduction bicyclic aromatic rings, such as naphthalyl quinoline groups, into N′-methylene position indoles’ modulators can effectively improve anti-tumor activity target compounds. Following our studies, series novel 1-(2-(6-methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-substituted...