A5043924795- Nuclear Receptors and Signaling
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Synthesis of Tetrazole Derivatives
- Natural product bioactivities and synthesis
- Retinoids in leukemia and cellular processes
- Fluorine in Organic Chemistry
- Estrogen and related hormone effects
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Organic Chemistry Cycloaddition Reactions
- Chemical Synthesis and Reactions
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- interferon and immune responses
- SARS-CoV-2 detection and testing
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Circular RNAs in diseases
- Nanopore and Nanochannel Transport Studies
- Retinal Imaging and Analysis
- GDF15 and Related Biomarkers
- Membrane Separation Technologies
- Retinal Diseases and Treatments
Xiamen University
2017-2024
Zhejiang Normal University
2023-2024
Fujian Medical University
2020-2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Provincial Hospital
2020
East China University of Science and Technology
2013-2016
Sichuan University
2016
Abstract Obesity, a global health challenge, is major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There an ongoing need to identify safe tolerable therapeutics obesity management. Herein, we show that treatment with artesunate, artemisinin derivative approved by the FDA of severe malaria, effectively reduces body weight improves metabolic profiles in preclinical models obesity, male mice overnutrition-induced cynomolgus macaques...
A hindered para-hydroxyl group-directed remote benzylic C(sp3)–H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcohols and alkyl ethers into various aromatic carbonyl compounds. The ligand- additive-free Cu(OAc)2-catalyzed atmospheric oxidation mediated by ethylene glycol unlocks a facile, atom-economical, environmentally benign CO formation functionalization primary secondary benzyl groups. Due...
Abstract We recently demonstrated that retinoic acid receptor-γ (RARγ) is overexpressed and acts as a tumor promoter in hepatocellular carcinoma (HCC). The oncogenic activity of RARγ mainly attributed to its physiological interaction with p85α regulatory subunit PI3K leading constitutive activation AKT. Here we report negative regulator p53 signaling thus extend the potential new role controlling balance between AKT p53. A natural flavonoid acacetin then identified be capable modulating...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Angiotensin-converting enzyme (ACE2) is an entry receptor for SARS-CoV-2. The full-length membrane form of ACE2 (memACE2) undergoes ectodomain shedding to generate shed soluble (solACE2) that mediates SARS-CoV-2 via receptor-mediated endocytosis. Currently, it not known how the physiological regulation contributes etiology COVID-19 in vivo. present study identifies Membrane-type 1 Matrix...
A facile, atom-economical, and efficient Cu(OAc)<sub>2</sub>-catalyzed oxidative esterification of substituted <i>p</i>-cresols was developed with ambient air as the terminal oxidant. This ligand- additive-free protocol allows an environmentally benign reagent-economical access to benzyl esters.
The androgen receptor (AR, Uniprot: P10275) signaling plays a key role in the progression of prostate cancer, various AR-related ligands have been reported to treat cancer. However, some resistance mechanisms limited treating effect these ligands. Since DBD binding or allosteric sites LBD AR may allow circumvention drug mechanisms, anti-resistance is expected especially through NTD (N-terminal domain) targeting. What's more, studies shown that compounds including EPI-001 and its derivatives...
In this paper, liquid-liquid chromatography was introduced for the first time separation of fingered citron (Citrus medica L. var. sarcodactylis Swingle). The cultivated in Jinhua is significant industrial and medicinal value, with several major coumarin compounds detected its extract. Therefore, further higher purity necessity. A preparative chromatographic method developed by combining two elution modes (isocratic step-gradient) selection according to different polarities target sample....
Abstract Background Cervical cancer is the most common gynecological worldwide and associated with high morbidity mortality. Despite improvements in therapeutic strategies, network regulation mechanism remains unclear treatment effect not satisfactory. Therefore, there a need to continue studying of cervical explore effective gene targets precise targeted therapy drugs. Methods First, three paired tissues (cancer noncancerous tissues) from patients squamous cell carcinoma were collected,...
Abstract The undecorated Cu(OAc) 2 ‐catalyzed para ‐hydroxy group triggered oxidative coupling of 2,6‐disubstituted 4‐cresols with fluorinated β‐keto esters or malonates leading to benzylic C(sp 3 )–C(sp ) bond formation was investigated. This formal double )–H method features mild conditions, atom economy, ligand‐ and additive‐free catalysis, ambient air as the terminal oxidant. ecofriendly allows rapid access highly functionalized 3‐phenylpropanoate derivatives containing quaternary...
Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety tumors. Many agonists have been reported to significant anticancer effects. Our previous studies found introduction bicyclic aromatic rings, such as naphthalyl quinoline groups, into N′-methylene position indoles’ modulators can effectively improve anti-tumor activity target compounds. Following our studies, series novel 1-(2-(6-methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-substituted...
Abstract 54 examples
Abstract Highly functionalized 3‐arylpropanoate derivatives containing a fluorinated quaternary carbon center are rapidly and ecofriendly obtained by oxidative coupling of 2,6‐disubstituted 4‐cresols with β‐ketoesters or malonates using ambient air as the terminal oxidant.
Objective: On the premise of ensuring sensitivity and specificity nucleic acid detection, explore choice number gene targets on detection reagent severe acute respiratory syndrome virus 2 (SARS-CoV-2), to reduce national medical burden.Methods: From February 25, 2020 March 11, 2020, a quality control material (each including 5 samples) were distributed 50 participating laboratories by Fujian Clinical Laboratory Center, each laboratory used different kits detect SARS-COV-2. As we received...