A5101594662- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Tracheal and airway disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Nuclear Receptors and Signaling
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Adenosine and Purinergic Signaling
Capital Medical University
2022-2025
Sichuan Cancer Hospital
2021-2025
University of Electronic Science and Technology of China
2021-2025
Zhejiang Chinese Medical University
2025
East China Normal University
2021-2024
Second Affiliated Hospital of Zhejiang University
2014-2024
Chizhou University
2024
Jining Traditional Chinese Medicine Hospital
2020-2023
First Affiliated Hospital of Soochow University
2018-2023
Soochow University
2018-2023
8500 Background: Neoadjuvant immune checkpoint inhibitors (ICIs) plus chemotherapy have a promising efficacy in resectable non-small-cell lung cancer (NSCLC), yet the period of neoadjuvant immunochemotherapy is undetermined. This phase II study compared and safety two cycles with three sintilimab stage IB-IIIA NSCLC. Methods: randomized, open-label trial recruited patients aged 18 or older histologically confirmed, treatment-naïve, American Joint Committee on Cancer-defined IB-IIIA, Eligible...
PIWI-associated RNAs (piRNAs or piRs), a new-found class of small non-coding RNAs, which are mainly expressed in germline cells and partly somatic lines, have vital role carcinogenesis by maintaining genomic integrity regulation epigenetics. The previous studies confirmed that the expression piR-651 is upregulated several cancer tissue cell including lung cancer. However, mechanism remains to be elucidated. Therefore, present study assessed 95-D high metastasis human line detect effect on...
Piwi‑interacting RNAs (piRNAs/piRs) are small non‑coding that can serve important roles in genome stability by silencing transposable genetic elements. piR651, one of these novel piRNAs, regulates a number biological functions, as well carcinogenesis. Previous studies have reported piR651 is overexpressed human gastric cancer tissues and several cell lines, including non‑small lung (NSCLC) lines. However, the role piRNAs carcinogenesis has not been clearly defined. In present study,...
Hepatocellular carcinoma (HCC) is one of the most common types cancer worldwide and its incidence continues to increase year by year. Endoplasmic reticulum stress (ERS) caused protein misfolding within secretory pathway in cells has an extensive deep impact on cell progression survival. Growing evidence suggests that genes related ERS are closely associated with occurrence HCC. This study aimed identify ERS-related signature for prospective evaluation prognosis HCC patients. RNA sequencing...
CD19-specific CAR-T immunotherapy has been extensively studied for the treatment of B-cell lymphoma. Recently, cholesterol metabolism emerged as a modulator T lymphocyte function and can be exploited in to increase efficacy CAR-based systems. Acetyl-CoA acetyltransferase 1 (ACAT1) is major esterification enzyme. ACAT1 inhibitors previously shown modulate cardiovascular diseases are now being implicated immunotherapy. In present study, we achieved knockdown cells via RNA interference...
Matrine has been reported to be an effective anti‑tumor therapy; however, the anti-metastatic effects of matrine on hepatocellular carcinoma (HCC) and molecular mechanism(s) involved remain unclear. Therefore, aims present study were evaluate hepatoma determine associated involved. In study, was confirmed prevent proliferation HCC cells it observed that also inhibited migratory, invasive capabilities at non‑toxic concentrations. Additionally, increased epithelial‑cadherin expression...
Background: Limited resection has gradually become an acceptable treatment for lung adenocarcinomas (ADCs) presenting as ground-glass nodules (GGNs). However, its role in ADCs pure solid (PSN) remains unclear. In this study, we aimed to identify potential candidates limited PSN. Methods: We retrospectively reviewed 772 patients from seven hospitals with ⩽2 cm, PSN on computed tomography scans, who had undergone surgery between 2009 and 2013. Histological subtypes were listed 5% increments....
Celastrol, a naturally occurring bioactive compound, has demonstrated potential in treating inflammation, obesity, and tumors, particularly colorectal, gastric, breast cancers. However, its therapeutic effects on thyroid cancer (TC), which have poor clinical outcomes, remain unclear. This study aimed to investigate Celastrol's using cell lines. The viability proliferation of cells treated with or without Celastrol were analyzed by CCK-8 colony formation assay. state observed microscopy....
ABSTRACT Copper deficiency, commonly observed in myocardial infarction, leads to cardiomyocyte loss and cardiac dysfunction, yet the mechanism driving copper efflux remains unclear. To further elucidate relationship between transporters during chronic ischemia, a rhesus monkey model was established by performing permanent ligation of left anterior descending coronary artery. A dramatic decrease concentration within ischemic cardiomyocytes alongside declining function. Among major...
Mesenchymal stem cell (MSC) transplantation has been proposed as a potential therapeutic approach for ischemic heart disease, but the regenerative capacity of these cells decreases with age. In this study, we genetically engineered old human MSCs (O-hMSCs) tissue inhibitor matrix metalloproteinase-3 (TIMP3) and vascular endothelial growth factor (VEGF) evaluated effects on efficacy cell-based gene therapy in rat myocardial infarction (MI) model. Cultured O-hMSCs were transfected TIMP3...
Background: Conventional video-assisted thoracoscopic surgery (VATS) lobectomy for locally advanced non-small cell lung cancer (NSCLC) is a feasible and safe in high-volume centers with significant VATS experience. Uniportal has been recently reported to be promising, less invasive approach. The purpose of this study explore the safety feasibility uniportal (U-VATS) treatment patients NSCLC.
Immunotherapy has shown excellent therapeutic effects on various malignant tumors; however, to date, immunotherapy for osteosarcoma is still suboptimal. In this study, we performed comprehensive bioinformatic analysis of immune-related genes (IRGs) and tumor-infiltrating immune cells (TIICs). Datasets differentially expressed IRGs were extracted from the GEO database (GSE16088). The functions prognostic values these systematically investigated using a series bioinformatics methods. addition,...
Abstract Pancreatic carcinoma (PC) is one of the most common malignancies. Chimeric antigen receptor (CAR)-modified T cells has achieved remarkable efficacy in treatment hematological However, lack tumor-specific targets and existence inhibitory factors limit function CAR when treating solid tumors. 4.1R been reported to suppress anti-tumor activity cell responses. In this study, we investigated deletion natural killer group 2D (NKG2D)-CAR against PC. The were obtained by transfecting with...
Non-small cell lung cancer (NSCLC) is currently a problem in the clinic and society. Tumor-related macrophages (TAMs) tumor microenvironment (TME) play vital role development of NSCLC.Bioinformatics was used to analyze Indoleamine 2,3-dioxygenase 1 (IDO1) NSCLC correlation its expression with CD163 expression. The IDO1 measured by immunohistochemistry, their colocalization assessed immunofluorescence. M2 macrophage polarization induced, coculture model cells established.Bioinformatics...
ABSTRACT This study investigated the effects of cyclin D1 gene silencing on cell proliferation and apoptosis interleukin‐1β (IL‐1β)‐induced osteoarthritis (OA) chondrocytes. Chondrocytes from healthy sprague‐dawley rats were divided into blank, OA model (chondrocytes underwent IL‐1β inducement), trial inducement with D1‐shRNA treatment), negative control (NC; chondrocytes control‐shRNA treatment) groups. Cell was assessed by CCK‐8 assay, cycle flow cytometry. qRT‐PCR Western blotting...
Objective: To study the general efficacy of hydromorphone as a systemic analgesic in postoperative pain management following single-port video-assisted thoracoscopic surgery (VATS) and to explore optimal administration regimen. Methods: A prospective, randomized, double-blind was designed conducted tertiary hospital. In total, 157 valid patients undergoing VATS were randomly allocated into three groups. total 53 received morphine bolus only for analgesia (Group Mb); 51 background infusion...