A5100384554- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Diet and metabolism studies
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Neurological Disease Mechanisms and Treatments
- Clostridium difficile and Clostridium perfringens research
- Allergic Rhinitis and Sensitization
- Cardiac Ischemia and Reperfusion
- Gastroesophageal reflux and treatments
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Nutrition and Health in Aging
- Traditional Chinese Medicine Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Asthma and respiratory diseases
- Hematopoietic Stem Cell Transplantation
- Enhanced Recovery After Surgery
- Immune Cell Function and Interaction
- Complementary and Alternative Medicine Studies
Sichuan Cancer Hospital
2023-2025
University of Electronic Science and Technology of China
2023-2025
The 180th Hospital of PLA
2025
Hainan Medical University
2023-2024
Nanchang University
2024
Guizhou Provincial People's Hospital
2024
General Hospital of Shenyang Military Region
2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2023
Beijing Tian Tan Hospital
2023
Abstract A photothermal genome‐editing strategy is described to improve immune checkpoint blockade (ICB) therapy by CRISPR/Cas9‐mediated disruption of PD‐L1 and mild‐hyperthermia‐induced activation immunogenic cell death (ICD). This relies on a supramolecular cationic gold nanorod that not only serves as carrier deliver CRISPR/Cas9 targeting , but also harvests the second near‐infrared‐window (NIR‐II) light converts into mild hyperthermia induce both ICD gene expression Cas9. The genomic...
Background: Tumor PD-L1 levels have predictive value in PD-1/PD-L1 checkpoint blockade therapies, yet biopsies can only provide baseline information. Whether expression on circulating tumor cells (CTCs) could serve as an alternative biomarker is of great interest. Design: We established immunofluorescence assay for semi-quantitative assessment the CTCs with four categories (PD-L1negative, PD-L1low, PD-L1medium and PD-L1high). 35 patients different advanced gastrointestinal tumors were...
Abstract Deficiency or mutation in the p53 tumor suppressor gene commonly occurs human cancer and can contribute to disease progression chemotherapy resistance. Currently, although pro-survival pro-death effect of autophagy remains a controversial issue, increasing data seem support idea that facilitates cell resistance treatment. Here we report 5-FU treatment causes aberrant autophagosome accumulation HCT116 −/− HT-29 cells. Specific inhibition by 3-MA, CQ small interfering RNA targeting...
Anthracycline daunorubicin (DNR) is one of the major antitumor agents widely used in treatment myeloid leukemia. Unfortunately, clinical efficacy DNR was limited because its cytotoxity at high dosage. As a novel cytoprotective mechanism for tumor cell to survive under unfavorable conditions, autophagy has been proposed play role drug resistance cells. Whether can activate impair sensitivity cancer cells remains unknown. Here, we first report that induce level autophagy, which associated with...
ABSTRACT Copper deficiency, commonly observed in myocardial infarction, leads to cardiomyocyte loss and cardiac dysfunction, yet the mechanism driving copper efflux remains unclear. To further elucidate relationship between transporters during chronic ischemia, a rhesus monkey model was established by performing permanent ligation of left anterior descending coronary artery. A dramatic decrease concentration within ischemic cardiomyocytes alongside declining function. Among major...
The purpose of this study was to explore the genetic characteristics and immune cell infiltration related intervertebral disc degeneration through multidataset analysis, predict potential therapeutic drugs, provide a theoretical basis for clinical treatment. gene expression profile data GSE70362, GSE186542, GSE245147 datasets were downloaded from Gene Expression Omnibus (GEO) database, hub genes identified differentially expressed Ontology (GO) Kyoto Encyclopaedia Genes Genomes (KEGG)...
To explore the knowledge, attitude, and practice (KAP) towards enhanced recovery after surgery (ERAS) among colorectal cancer (CRC) patients. This cross-sectional study included CRC patients who underwent selective operation at author's Hospital, between April 2021 2023. Their demographic characteristics KAP ERAS were collected using a self-designed questionnaire. A total of 652 valid questionnaires collected, with scores 37.29 ± 11.35 (possible range: 11-55), 39.51 6.40 6.53 2.21 0-8),...
Pancreatic cancer is one of the leading causes cancer-related mortality in both developed and developing countries. The incidence pancreatic China accounts for about a quater global incidence, epidemiological characteristics therapeutic strategies differ due to social, economic, cultural, environmental, public health factors. Non-domestic guidelines do not reflect clinicopathologic treatment patterns Chinese patients. Thus, 2018, Society Clinical Oncology (CSCO) organized panel senior...
Nanobodies (VHHs) overcome many of the drawbacks conventional antibodies, and related technologies represent state-of-the-art advanced applications in scientific research, pharmaceuticals, therapies. In terms productivity economic cost, cytoplasmic expression VHHs Escherichia coli (E. coli) is a good process for their recombinant production. The environment host critical to affinity stability soluble form, yet effects have not been studied. For this purpose, anti-β2 microglobulin were...
Pancreatic adenocarcinoma has an exceedingly poor prognosis, accounting for five-year survival of less than 5%. Presently, improving the efficacy pancreatic treatment been focus medical researchers worldwide. Recently, it suggested that deregulation interleukin- (IL-) 6 is caused by a key gene involved in beginning and development adenocarcinoma. Herein, we investigated whether suppression IL-6 could augment gemcitabine sensitivity PANC-1 cells. We found considerably higher expression...
This study aimed to evaluate the efficacy, adverse events, patient compliance, and cost of dual therapy with Ilaprazole-amoxicillin (IA) at high dose versus Ilaprazole-amoxicillin-furazolidone-bismuth (IAFB) quadruple for Helicobacter pylori (H.pylori) infection among Chinese patients.
Preoperative noninvasive diagnosis of the benign or malignant solitary pulmonary nodule (SPN) is still important and difficult for clinical decisions treatment. This study aimed to assist in preoperative SPN using blood biomarkers.A total 286 patients were recruited this study. The serum FR+CTC, TK1, TP, TPS, ALB, Pre-ALB, ProGRP, CYFRA21-1, NSE, CA50, CA199, CA242 detected analyzed.In univariate analysis, age, CA19.9, CA242, TPS showed statistical significance a correlation with SPNs (P...
Circulating tumor cells (CTCs) or CTC clusters are considered as suitable and relevant targets for liquid biopsy they more accurately indicate cancer progression, the therapeutic effects of treatment allows monitoring metastasis in real‑time. Among various methods isolating CTCs, size‑based filtration is one most convenient methods. However, cell clogging makes process less efficient. In present study, an electromagnetic vibration‑based (eVBF) device was developed that efficiently isolated...
To assess the value of direct digital radiography (DR) and CT in screening tuberculosis. In a tuberculosis outbreak May, 2014, both chest DR were taken close contacts (n = 35 cases). The chi square test ROC curve used to evaluate calculate missed pulmonary lesions from natures these lesions. Abnormal shadow detection rates 22.9% (8/35) 40% (14/35) respectively, difference was statistically significant (χ2 16.154, P < 0.01). 6 cases DR, 3 showed with anatomical occult or overlap, such as...