A5102899935- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Galectins and Cancer Biology
- Drug-Induced Hepatotoxicity and Protection
- Cardiac Fibrosis and Remodeling
- Trace Elements in Health
- Cardiac electrophysiology and arrhythmias
- Systemic Lupus Erythematosus Research
- Molecular Biology Techniques and Applications
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- COVID-19 and healthcare impacts
Sichuan Cancer Hospital
2021-2025
University of Electronic Science and Technology of China
2021-2025
Dalian Medical University
2019
Nanfang Hospital
2014-2017
Southern Medical University
2014-2017
Eighth Affiliated Hospital of Sun Yat-sen University
2017
Sun Yat-sen University
2017
The metastasis-associated lung adenocarcinoma transcription 1 (Malat1) is a long non-coding RNA (lncRNA), exerts oncogenic role in multiple cancers, including hepatocellular carcinoma (HCC). This study was aimed to investigate its posttranscriptional regulation HCC cells. RT-PCR performed monitor the expression levels of Malat1 normal liver and cell lines. Malat1, microRNA (miR)-195, epidermal growth factor receptor (EGFR) HepG2 MHCC97 cells respectively or synchronously altered by...
Idiopathic pulmonary fibrosis (IPF) is a chronic lethal disease in the absence of demonstrated efficacy for preventing progression. Although macrophage-mediated alveolitis determined to participate myofibrotic transition during development, paradigm continuous macrophage polarization still under-explored due lack proper animal models. Here, by integrating 2.5 U/kg intratracheal Bleomycin administration and 10 Gy thorax irradiation at day 7, we generated murine model with alveolitis-mediated...
ABSTRACT Copper deficiency, commonly observed in myocardial infarction, leads to cardiomyocyte loss and cardiac dysfunction, yet the mechanism driving copper efflux remains unclear. To further elucidate relationship between transporters during chronic ischemia, a rhesus monkey model was established by performing permanent ligation of left anterior descending coronary artery. A dramatic decrease concentration within ischemic cardiomyocytes alongside declining function. Among major...
Sialylation is up-regulated during the development of cardiac hypertrophy. Sialyltransferase7A (Siat7A) mRNA consistently over-expressed in hypertrophic left ventricle hypertensive rats independently genetic background. The aims this study were: (i) to detect Siat7A protein levels and its roles pathological cardiomyocyte hypertrophy; (ii) elucidate effect sialylation mediated by on transforming-growth-factor-β-activated kinase (TAK1) expression activity (iii) clarify hypoxia-inducible factor...
Abstract Objectives Autoimmune diseases are a heterogeneous group of which lose the immunological tolerance to self‐antigens. It is well recognized that irregularly provoked T cells participate in pathological immune responses. As novel nanomaterial with promising applications, tetrahedral framework nucleic acid (TFNA) nanostructure was found have regulatory effects on this study. Materials and Methods To verify successful fabrication TFNA, morphology TFNA observed by atomic force microscopy...
This study examined the application of 64-slice spiral double-low computed tomography (CT) to evaluate degree coronary artery stenosis. We 45 patients with heart disease by CT and angiography (CAG) determine accuracy in evaluating Imaging analysis from identified 199 segments stenosis patients, including 46 mild stenosis, 38 moderate 115 severe or occlusion. agreed CAG on identification 122 segments, an overall 61.3%. The for serious occlusion was highest at 69.6%. also found a strong...
Objective To investigate the validity of ultrasonic index (USI) in detecting compensated hepatitis B cirrhosis and improvement by stepwise combination transient elastography (TE) USI.Methods Total 222 patients with undergone liver biopsies were retrospectively investigated.Patients' hematology,serum biochemical index,coagulation index,TE ultrasonography liver,gallbladder spleen statistically analyzed to evaluate diagnostic efficiency.Results There statistical differences between without...
The term seizure refers to certain physical or behavioral actions that may occur after an episode of abnormal electrical activity in the brain. Epileptic seizure, one major types, affects about 1% population currently and has affected 4% at some point time. Most those by seizures (nearly 80%) live developing countries. Soman, also known as GD, is extremely toxic man‐made organophosphorous chemical. Exposure GD frequently results seizures, well neuropathological neurochemical abnormalities...