A5100401227- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Total Knee Arthroplasty Outcomes
- Moyamoya disease diagnosis and treatment
- Orthopaedic implants and arthroplasty
- Spine and Intervertebral Disc Pathology
- Gestational Diabetes Research and Management
- Intracranial Aneurysms: Treatment and Complications
- Knee injuries and reconstruction techniques
- Bone fractures and treatments
- Pregnancy and preeclampsia studies
- Cancer Research and Treatments
- Cervical and Thoracic Myelopathy
- Congenital heart defects research
- Genomics and Phylogenetic Studies
- HIV Research and Treatment
- Spinal Fractures and Fixation Techniques
- Medical Imaging Techniques and Applications
- Neurological Complications and Syndromes
- Electrocatalysts for Energy Conversion
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
Beihang University
2012-2025
The 180th Hospital of PLA
2016-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Ministry of Industry and Information Technology
2025
Weifang People's Hospital
2025
Bohai University
2023-2024
Shandong University of Traditional Chinese Medicine
2022-2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Background and Purpose— Here we describe the clinical features outcomes of patients with moyamoya disease who were surgically treated at a single institution in China. Methods— Our cohort included 802 disease. Demographic characteristics obtained by retrospective chart review; follow-up information outcome through visits, telephone, or letter interview. We used Kaplan-Meier methods to estimate stroke risk treatment status. Results— The median age for onset symptoms was 28 (range, 0.5–77)...
Anisotropic meniscus engineered using biomechanical, biochemical, and structural cues demonstrates long-term knee chondroprotection in rabbits.
Background and Purpose— Predicting the risk of stroke determining intervention indications are highly important for patients with Moyamoya disease (MMD). Here, we evaluated a novel MMD grading system based on collateral circulation Suzuki stage to evaluate symptoms predict prognosis. Methods— In total, 301 idiopathic were retrospectively analyzed between 2014 2016. A scores ranging from 1 12 was established: anatomic extent pial blood flow posterior cerebral artery middle anterior scored 6;...
AP-2 transcription factors are sequence-specific DNA-binding proteins expressed in neural crest and other tissues during mammalian development. Three genes, <i>AP-2α</i>,<i>AP-2β</i>, <i>AP-2γ</i>, have been reported previously. A partial predicted <i>AP-2</i> gene was identified tandem with <i>AP-2β</i> on human chromosome 6p12-p21.1. The orthologous mouse gene, which we named <i>Ap-2δ</i>, from a fetal head cDNA library. Northern analysis revealed two transcripts embryonic newborn brain,...
Moyamoya disease (MMD) is a rare cerebral vasculopathy characterized by bilateral internal carotid artery stenosis and often leads to stroke in children or young adults. Although familial inheritance well recognized, the genetic basis of MMD remains poorly understood.A 2-stage genome-wide association study was conducted involving 1492 cases 5084 controls. In discovery stage, logistic regression used test associations, imputation based on genotyped single-nucleotide polymorphisms (SNPs)....
Curcumin is a chemical constituent extracted from Curcuma longa L. Several clinical and preclinical studies have demonstrated that it can mitigate exercise fatigue, but the exact mechanism still unknown. Therefore, we applied mouse model of fatigue to investigate possible molecular mechanisms curcuminâs anti-fatigue effect. Depending on body mass, Kunming mice were randomly divided into control, caffeine (positive drug), curcumin groups, given 28 days intragastric administration. Both...
An immunoassay protocol is described to detect tumor markers in human serum based on a sandwich structure consisting of nano-Si immune probes and SiC@Ag SERS-active substrate.
Abstract Cytokine storm (CS) is linked with macrophage dysfunction and acute lung injury (ALI), which can lead to patient mortality. Glycolysis preferentially exploited by the pro-inflammatory macrophages, in pyruvate kinase M2 (PKM2) a critical enzyme. The mechanism underlying link between CS ALI involves cell death, recently discovered programmed death known as ferroptosis being involved. However, relationship glycolysis context of CS-related remains unclear. CS-associated induced poly I:C...
Patent ductus arteriosus (PDA) is one of the most common forms congenital heart disease. Mutations in transcription factor TFAP2B cause Char syndrome, a human disorder characterized by PDA, facial dysmorphysm and hand anomalies. Animal research data are needed to understand mechanisms. The aim our study was elucidate pathogenesis syndrome at molecular level.Gene expression Tfap2b during mouse development studied, newborns Tfap2b-deficient mice were examined identify phenotypes. Gel shift...
The employment of stoichiometric alcohols and amines for imine synthesis under mild green reaction conditions is still a challenge in the field. In this work, based on our research foundation thermocatalytic imines over ceria, CdS/CeO2 heterojunction photocatalyst was constructed successfully realized atom-economic visible light without additives at room temperature. Mechanistic experiments corresponding characterizations indicated that can improve separation efficiency photogenerated...
The preparation of low-dimensional covalent–organic frameworks (COFs) is currently a hot and challenging research topic, especially for zero-dimensional (0D) COF quantum dots (COQDs). Herein, the first time we introduce facile efficient approach to fabricating COQDs by selectively disassembling hydrogen-covalent hybridized organic (H–COFs). By taking advantage disparate stabilities between noncovalent covalent bonds within periodic lamellar structures H–COFs, disrupt hydrogen through...
OBJECTIVE The object of this study was to summarize the long-term effect encephaloduroarteriosynangiosis (EDAS) for treatment pediatric moyamoya disease (MMD) and investigate factors influencing clinical outcomes EDAS. METHODS Clinical features, angiographic findings, were analyzed among MMD patients younger than 18 years who had been treated with EDAS between 2002 2007 at authors' institution. Kaplan-Meier method used estimate stroke risk after Predictors neurological outcome assessed....
Gestational diabetes mellitus (GDM) is a growing public health concern for many reasons, and its etiology remains unclear. Due to the similarity of pathophysiology with type 2 (T2DM), we evaluated relationship between published T2DM susceptibility genes risk GDM. A total 303 SNPs from including IRS1, IGF2BP2, CDKAL1, GCK, TCF7L2, KCNQ1, KCNJ11 GDM were examined in nested case-control study 321 cases 316 controls. The odds ratios (ORs) their 95% confidence interval (95% CI) estimated by...
Meniscus tears can change the biomechanical environment of knee joint and might accelerate development osteoarthritis. The aim this study was to investigate dynamic effects different medial meniscus tear positions gaps on during walking. Seven finite element models were constructed, including intact (IMM), radial stable in anterior, middle, posterior one-third regions (RSTA, RSTM, RSTP), corresponding unstable (RUTA, RUTM, RUTP). seven applied a 1000 N axial static load human walking load,...
The recent advances in information technology and artificial intelligence have fueled a rapid expansion of the data center (DC) industry worldwide, accompanied by an immense appetite for electricity to power DCs. In typical DC, around 30~40% energy is spent on cooling system rather than computer servers, posing pressing need developing new energy-saving optimization technologies DC systems. However, optimizing such real-world industrial systems faces numerous challenges, including but not...
Cancer cells evade immune detection through checkpoint molecules like PD-L1 and PD-L2 which suppress T-cell activation. While is well-studied, the role of remains unclear. Pyruvate kinase M2 (PKM2), a metabolic enzyme, influences regulation, but its in modulation not well defined. Here, we investigate pyruvate (PKM2) modulating via GATA3 cancer cells, with insights from both human mouse models. We find that PKM2 enhances expression while inhibiting PD-L2, dual regulatory mechanism...