A5101997469- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Cancer Treatment and Pharmacology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Drug Transport and Resistance Mechanisms
- Melanoma and MAPK Pathways
- Cancer, Lipids, and Metabolism
- Pain Mechanisms and Treatments
- Immune Cell Function and Interaction
- Botulinum Toxin and Related Neurological Disorders
- Metastasis and carcinoma case studies
XinHua Hospital
2013-2023
Shanghai Jiao Tong University
2013-2023
First Affiliated Hospital of Xi'an Jiaotong University
2022
CVS Health (United States)
2018
First Affiliated Hospital of Henan University of Science and Technology
2018
Shanghai First People's Hospital
2013-2016
Academy of Military Medical Sciences
2013-2016
Academy of Medical Sciences
2016
Second Affiliated Hospital of Nanjing Medical University
2016
Fudan University Shanghai Cancer Center
2016
Purpose There is currently no standard treatment strategy for patients with advanced metastatic gastric cancer experiencing progression after two or more lines of chemotherapy. We assessed the efficacy and safety apatinib, a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, in gastroesophageal junction adenocarcinoma whom at least prior chemotherapy had failed. Patients Methods This was randomized, double-blind, placebo-controlled phase III trial. from 32 centers...
Patients with metastatic gastric cancer (mGC) who do not respond to or experience progression second-line chemotherapy have no treatment options that clearly confer a survival benefit. This trial investigated the safety and efficacy of apatinib, an inhibitor vascular endothelial growth factor receptor, as option for heavily pretreated patients mGC.Patients experienced failure at least two chemotherapeutic regimens were randomly assigned receive placebo (group A), apatinib 850 mg once daily...
The V325 study showed that docetaxel, cisplatin, and fluorouracil (DCF) prolonged overall survival (OS) of patients with advanced gastric cancer, but a high incidence dose-limiting toxicities. We investigated the efficacy safety modified DCF (mDCF) regimen for Chinese cancer.Untreated cancer randomly received docetaxel cisplatin at 60 mg/m(2) (day 1) followed by 600 mg/m(2)/day (days 1-5; mDCF regimen) or 75 CF) every 3 weeks. primary end point was progression-free (PFS). secondary points...
Reliable biomarkers of apatinib response in gastric cancer (GC) are lacking. We investigated the association between early presence common adverse events (AEs) and clinical outcomes metastatic GC patients. conducted a retrospective cohort study using data on 269 apatinib-treated patients two trials. AEs were assessed at baseline until 28 days after last dose apatinib. Clinical compared with without hypertension (HTN), proteinuria, or hand foot syndrome (HFS) first 4 weeks. Time-to-event...
Gastric cancer remains a major health issue and leading cause of death worldwide. This study presented long-term survival data gastric registered in Shanghai China from 1972–2003, with aims to describe the trends as well age, sex, stage tumor sites specific characteristics. The main source information on cases was notification card sending registry. residential status confirmed by home-visits. methods follow-up have been mixture both active passive ones. We observed an increased trend...
The aim of this study was to perform a systematic review and meta-analysis evaluate the value Glasgow prognostic score (GPS) or modified (mGPS) in patients with colorectal cancer (CRC).A comprehensive medical literature search performed using online databases PubMed, Embase, Web Science, Cochrane Library. After extracting basic characteristics data from included studies, overall survival (OS) cancer-specific (CSS) were pooled as primary outcomes. Subgroup analyses according therapeutic...
Neuroblastoma (NB) is the most common pediatric solid tumor that originates from neural crest-derived sympathoadrenal precursor cells are committed to development of sympathetic nervous system. The well differentiated histological phenotype NB has been reportedly associated with favorable patient outcome. Retinoic acid (RA) can effectively induce cell differentiation, thereby being used in clinic as a treatment agent for inducing differentiation high-risk NB. However, underlying molecular...
Abstract Fulminant hepatic failure (FHF) is a potentially fatal liver disease that associated with intrahepatic infiltration of inflammatory cells. As the receptor polyunsaturated long chain fatty acids, GPR120 can regulate cell differentiation, proliferation, metabolism, and immune response. However, whether involved in FHF remains unknown. Using Propionibacterium acnes ( P. )-primed, LPS-induced mice, we found interference activity using pharmacological agonist attenuated severity injury...
Objective: This study aims to investigate the effects and feasibility of integrating music therapy into a family support system (FSS) for adolescent depression. Methods: In this retrospective study, 120 adolescents with depression who visited Wenzhou Seventh People’s Hospital between June 2022 2024 were selected categorized group conventional (60 cases in each group). The received FSS-assisted treatment medication, whereas was given based on treatment. Hamilton Depression Rating Scale...
Aberrant expression of a zinc transporter ZIP4 in pancreatic ductal adenocarcinoma (PDAC) has been shown to contribute tumor progression and is potential target for individualized therapy. The overall objective this study was determine whether could serve as novel diagnostic prognostic marker human PDAC, if it can be assessed by minimally invasive sampling using endoscopic ultrasound guided fine needle aspiration (EUS-FNA). Immunohistochemistry performed compare the PDAC samples obtained...
Pancreatic cancer is one of the leading causes cancer-related mortality in both developed and developing countries. The incidence pancreatic China accounts for about a quater global incidence, epidemiological characteristics therapeutic strategies differ due to social, economic, cultural, environmental, public health factors. Non-domestic guidelines do not reflect clinicopathologic treatment patterns Chinese patients. Thus, 2018, Society Clinical Oncology (CSCO) organized panel senior...
KRAS is widely mutated in human cancers, resulting unchecked tumor proliferation and metastasis, which makes identifying KRAS-targeting therapies a priority. Herein, we observe that mutant specifically promotes the formation of ERK2-p53 complex stomach/colorectal cells. Disruption this by applying MEK1/2 ERK2 inhibitors elicits strong apoptotic responses p53-dependent manner, validated genome-wide knockout screening. Mechanistically, p53 physically associates with phosphorylated through...
// Qi Shi 1, * , Wen Li Hongjia 1 Qiqi Le 3 Shanshan Liu Shaoqi Zong Leizhen Zheng 2 Fenggang Hou Oncology Department of Municipal Hospital Traditional Chinese Medicine, Shanghai University 200071, China Xin Hua Affiliated To Jiaotong School Shanghai, 200092, Digestive These authors contributed equally to this work Correspondence to: Hou, e-mail: fghou555@126.com Zheng, zhengleizhen2006@126.com Keywords: chemotherapy-induced nausea and vomiting (CINV), highly emetogenic chemotherapy,...
Predicting lymph node metastasis (LNM) accurately is very important to decide treatment strategies preoperatively. The aim of this study was explore risk factors that predict the presence LNM in early gastric cancer (EGC). A total 230 patients with EGC who underwent curative gastrectomy adenectomy at Xinhua Hospital from January 2006 July 2014 were retrospectively reviewed. We studied relationship between clinicopathological factors, biological markers (p53, ki67, nm23, vascular endothelial...
Gastric cancer (GC) is one of the most common malignant tumors in world. As anti-angiogenic therapy shows efficacy treatment GC, but only works certain patients, identification potential beneficiaries are urgently required order to apply appropriate treatments. The Lauren classification demonstrates numerous differences etiology, epidemiology and pathology; however, association between pro-angiogenic factors remains unclear. present study aimed investigate clinicopathological associated with...
The present study aimed to evaluate the efficacy and safety of acetyl-L-carnitine (ALC) for treatment chemotherapy-induced peripheral neuropathy (CIPN). was carried out as a prospective, randomized, double-blind, placebo-controlled paralleled clinical study. A total 239 patients with CIPN were selected subjects. Of subjects, 118 subjects received 3 g/day ALC orally 8 weeks 121 placebo. primary endpoint improvement by at least one grade. Patient status assessed week 4, 12 after enrollment...
Targeting the PD-1/PD-L1 pathway has emerged as a novel therapy for cancer. To identify rational candidates anti-PD-1/PD-L1 immunotherapy in gastric cancer (GC), abundance of PD-L1 expression was evaluated on kind biomarker-based molecular classification shaping prognosis and treatment planning.One hundred sixty-five GCs were classified into five subgroups using immunohistochemistry (IHC) situ hybridization (ISH) methods, based panel seven markers (MLH1, PMS2, MSH2, MSH6, E-cadherin, P53,...
This retrospective study was conducted to evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) ablation combined with Gemcitabine Oxaliplatin (Gemox) for treatment middle advanced pancreatic cancer in elderly patients.Forty-seven patients treated HIFU Gemox were evaluated inclusion, 38 cases finally included. The primary endpoint safety. Secondary endpoints included response rate, clinical benefit (CBR), overall survival (OS), progression-free (PFS).After combination...