A5101916092- Hepatitis B Virus Studies
- Non-Invasive Vital Sign Monitoring
- Cancer-related molecular mechanisms research
- ECG Monitoring and Analysis
- Bacteriophages and microbial interactions
- Hepatitis C virus research
- interferon and immune responses
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Virus-based gene therapy research
- GDF15 and Related Biomarkers
- Phonocardiography and Auscultation Techniques
- Signaling Pathways in Disease
- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Liver Disease Diagnosis and Treatment
- Plant Disease Resistance and Genetics
- Plant Molecular Biology Research
- Plant Virus Research Studies
- Gait Recognition and Analysis
- Context-Aware Activity Recognition Systems
- Inflammation biomarkers and pathways
- Immune Cell Function and Interaction
First Hospital of Lanzhou University
2025
Air Force Medical University
2013-2024
Beijing Institute of Petrochemical Technology
2022-2024
Second Affiliated Hospital of Zhejiang University
2024
Chongqing University
2024
First People's Hospital of Chongqing
2024
China Academy of Safety Sciences and Technology
2022-2023
Lanzhou University
2020-2023
Heriot-Watt University
2020-2022
Zhejiang University
2021
To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells secrete a large number non-coding RNA-containing exosomes that facilitate development and metastasis. However, precise mechanisms cell-derived during hypoxia are unknown. Here, we aim to clarify whether affects growth progression by transferring long RNA-urothelial cancer-associated 1 (lncRNA-UCA1) enriched secreted from bladder cancer cells. We used 5637 with high expression lncRNA-UCA1 as exosome-generating UMUC2...
Recent evidence shows that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon (IFN) genes (STING) signaling is essential for antitumor immunity by inducing the production type I IFN and thus activating both innate adaptive based on gene knockout mouse models. However, extensive detection expression cGAS/STING in human cancer mining roles this pathway have not been performed until now. In study, we revealed four key molecules (cGAS, STING, TANK binding kinase 1 [TBK1], regulatory factor...
A motion artefact is a kind of noise that exists widely in wearable electrocardiogram (ECG) monitoring. Reducing challenging ECG signal preprocessing because the spectrum usually overlaps with very important spectral components signal. In this paper, performance finite impulse response (FIR) filter, infinite (IIR) moving average median wavelet transform, empirical mode decomposition, and adaptive filter reduction studied compared. The results study demonstrate performs better than other...
Abstract Background Radiation exerts direct antitumor effects and is widely used in clinics, but the efficacy severely compromised by tumor resistance. Therefore uncovering mechanism of radioresistance might promote development new strategies to overcome manipulating activity key molecules. Methods Immunohistochemistry were find whether mTOR over-activated radioresistant patients’ biopsies. Then Western blot, real-time PCR transfection radiotherapy regulates expression modulating its...
The core protein (HBc) of hepatitis B virus (HBV) has been implicated in the malignant transformation chronically-infected hepatocytes and displays pleiotropic functions, including RNA- DNA-binding activities. However, mechanism by which HBc interacts with human genome to exert effects on hepatocyte function remains unknown. This study investigated distribution binding promoters evaluated its related genes' expression.Whole-genome chromatin immunoprecipitation microarray (ChIP-on-chip)...
The DNA damage response (DDR) is one of the most important mechanisms platinum resistance in ovarian cancer. Some miRNAs have been identified to be involved regulatory network DDR, thus abnormal expression might affect chemosensitivity In this study, by assessing simultaneously targeting a set DDR genes that exhibited platinum, we found miR-211 inhibited those genes, and proposed sensitivity cancer cells multiple thereby determine prognosis To verify hypothesis, analyzed association between...
Human activity recognition (HAR) is becoming increasingly important, especially with the growing number of elderly people living at home. However, most sensors, such as cameras, do not perform well in low-light environments. To address this issue, we designed a HAR system that combines camera and millimeter wave radar, taking advantage each sensor fusion algorithm to distinguish between confusing human activities improve accuracy settings. extract spatial temporal features contained...
Nonalcoholic steatohepatitis (NASH) is a metabolism-associated fatty liver disease with accumulated mitochondrial stress, and targeting function potential therapy. The genome-encoded bioactive peptide MOTS-c plays broad physiological roles, but its effectiveness direct targets in NASH treatment are still unclear. Here, we show that long-term preventive short-term therapeutic effects of treatments alleviate NASH-diet-induced steatosis, cellular apoptosis, inflammation, fibrosis. Mitochondrial...
Pulmonary fibrosis (PF) is always exacerbated by the comorbidity of lung adenocarcinoma (LUAD), and patients frequently died from complications PF instead cancer. Although many studies have unveiled mechanisms underlying exacerbation due to cancer resection radiotherapy, influence itself on remains enigmatic. We cocultivated mouse pulmonary cells with LUAD explore pathogenesis progression PF. Additionally, a model was established in mice via intratracheal injection bleomycin (BLM) followed...
A combination administration of chemical agents was highlighted to treat tumors. Recently, tumor cell has been found be different from normal in metabolic manner. Most cancer cells prefer aerobic glycolysis mitochondrial oxidative phosphorylation (OXPHOS) satisfy energy and biomass synthesis requirement survive, grow proliferate, which provides novel potential therapeutic targets for chemotherapy. Here, 2-deoxy-d-glucose (2-DG), a potent inhibitor glucose metabolism, used inhibit cells;...
Macrophages, characterized by considerable diversity and plasticity, play a crucial role in broad spectrum of biological processes, including inflammation. However, the molecular mechanisms underlying diverse phenotypes macrophages are not well defined. Here, we show that RNA-binding protein, quaking (QKI), dynamically modulates macrophage polarization states. After lipopolysaccharide (LPS) stimulation, QKI-silenced RAW 264.7 cells displayed pro-inflammatory M1 phenotype increased expression...
It has been revealed that 2'3'-cyclic-GMP-AMP (cGAMP), a second messenger activates the antiviral stimulator of IFN genes (STING), elicits an antitumoral immune response. Since cGAMP cannot cross cell membrane, it is not clear how intracellular STING activated by extracellular until SLC19A1 was identified as importer to transport into cytosol. However, SLC19A1-deficient cells also sense cGAMP, suggesting presence mechanisms other than facilitating transporters for sensing cGAMP. Here, using...
Noise is a common problem in wearable electrocardiogram (ECG) monitoring systems because the presence of noise can corrupt ECG waveform causing inaccurate signal interpretation. By comparison with electromagnetic interference and its minimization, reduction motion artifact more difficult challenging time-frequency characteristics are unpredictable. Based on artifacts, this work uses adaptive filtering, specially designed device, an Impedance Pneumography (IP) data acquisition system to...
ObjectivesDihydroartemisinin (DHA), an artemisinin derivative extracted from the traditional Chinese medicinal herb Artemisia annua, has potential to suppress head and neck squamous cell carcinoma (HNSCC) progression. However, mechanisms underlying these effects remain unclear. Therefore, we aimed examine of DHA on tumor invasion migration.MethodsHuman HNSCC lines CAL-27 FaDu were exposed varying concentrations (0, 5, 20, 80 μM) for 24 h. Cell proliferation, invasion, migration assessed...
Human activity recognition (HAR) can effectively improve the safety of elderly at home. However, non-contact millimeter-wave radar data on activities is often challenging to collect, making it difficult accuracy neural networks for HAR. We addressed this problem by proposing a method that combines improved principal component analysis (PCA) and VGG16 model (a pre-trained 16-layer network model) enhance HAR under small-scale datasets. This used PCA features extracted components reduce...
The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar C1q mannose-binding lectin (MBL) participate in microbe infection apoptotic cell clearance by activating the complement pathway or primitive opsonophagocytosis. It remains unknown whether interplay ficolins immunosurveillance. Here we report natural killing different types cells sera...
Idiopathic Pulmonary Fibrosis (IPF) is identifiable by the excessive increase of mesenchyme paired with loss epithelium. Total flavonoids Astragalus (TFA), main biologically active ingredient traditional Chinese medicine, membranaceus (Huangqi), shows outstanding effects on treating pulmonary disorders, including COVID-19-associated dysfunctions. This study was designed to evaluate efficacy TFA fibrosis and possible mechanisms behind these effects. A549 cells were treated TGF-[Formula: see...
Various factors play key roles in maintaining intestine homeostasis. Disruption of the balance may lead to inflammatory bowel diseases and even colorectal cancer (CRC). Loss or gain function many proteins can result dysregulated intestinal Our research demonstrated that neural precursor cells expressed developmentally downregulated 4-like protein (NEDD4L, NEDD4-2), a type HECT family E3 ubiquitin ligase, played an important role NEDD4L expression was significantly inhibited epithelial (IECs)...
Abstract Inflammatory bowel disease (IBD) is a refractory chronic inflammatory illness of the gastrointestinal (GI) tract. Macrophage exerts an important role in IBD development. QKI, as RNA binding protein, was related with responses bacterial infections by regulating polarization macrophages. Therefore, we suspected that QKI-regulated macrophages have potential to play certain and underlying mechanism. Our results demonstrated mice macrophage-specific deletion QKI induced dextran sodium...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through interactions with its receptor, Angiotensin-converting enzyme (ACE2), causing severe and death in a considerable proportion of people. Patients infected SARS-CoV-2 experience digestive symptoms. However, the precise protein expression atlas ACE2 gastrointestinal tract remains unclear. In this study, we aimed to explore pattern underlying function tract, including colon, stomach, liver, pancreas.We...
BACKGROUND: Chemotherapy-related hepatic dysfunction affected the prognosis of non-small cell lung cancer (NSCLC). However, predictive factors chemotherapy-related remained undefined. OBJECTIVE: To identify for during cytotoxic chemo therapy in Chinese patients with advanced NSCLC. METHODS: We retrospectively reviewed medical records NSCLC who received chemotherapy at Division Respiratory Medicine, affiliated Drum Tower Hospital Nanjing University, from July 2012 to January 2015....