A5060279706- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Urinary Bladder and Prostate Research
- RNA regulation and disease
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Advanced Proteomics Techniques and Applications
- Pelvic floor disorders treatments
- Viral Infections and Immunology Research
- Prostate Cancer Diagnosis and Treatment
- Microbial Metabolic Engineering and Bioproduction
- Cancer, Hypoxia, and Metabolism
- Molecular Biology Techniques and Applications
- Microwave Engineering and Waveguides
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Advanced Nanomaterials in Catalysis
- Renal Diseases and Glomerulopathies
- Antenna Design and Analysis
- Biofuel production and bioconversion
- RNA modifications and cancer
- interferon and immune responses
- Interpreting and Communication in Healthcare
- Connexins and lens biology
First Affiliated Hospital of Zhengzhou University
2020-2025
Second Hospital of Shandong University
2021-2024
Beijing University of Chemical Technology
2024
Guangzhou University of Chinese Medicine
2022-2024
Danone (China)
2024
Juntendo University
2024
Juntendo University Hospital
2024
Qinghai Provincial Peoples Hospital
2024
Air Force Medical University
2001-2023
VA Boston Healthcare System
2009-2023
Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile posttranslational modifications involved in neoantigen formation. Using mass spectrometry, identified panel of cysteine residues differentially modified carboxyethylation required 3-hydroxypropionic acid generate patients with AS. The lysosomal degradation integrin αIIb [ITGA2B (CD41)] carboxyethylated at Cys96 (ITGA2B-ceC96)...
Cytoplasmic STAT3, after activation by growth factors, translocates to different subcellular compartments, including nuclei and mitochondria, where it carries out biological functions. However, the precise mechanism which STAT3 undergoes mitochondrial translocation subsequently regulates tricarboxylic acid (TCA) cycle-electron transport chain (ETC) remains poorly understood. Here, we clarify this process visualizing acetylation in starved cells serum reintroduction or insulin stimulation....
Transition metal oxides (TMOs) are promising cathode materials for aqueous zinc ion batteries (ZIBs), however, their performance is hindered by a substantial Hubbard gap, which limits electron transfer and battery cyclability. Addressing this, we introduce heteroatom coordination approach, using triethanolamine to induce axial N on Mn centers in MnO
Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, precise molecular mechanisms remain unclear, and pathway predominantly contributing to DKD is particular interest. In this study, glomerular proteome, especially profiles proteins, was analyzed biopsies from 40 patients 10 normal controls using laser microdissection-assisted liquid chromatography-tandem mass spectrometry (LMD-LC-MS/MS). The abundances...
Elevated interleukin-6 (IL-6), a major mediator of the inflammatory response, has been implicated in androgen receptor (AR) activation, cellular growth and differentiation, plays important roles development progression prostate cancer, is potential target cancer therapy. Through drug screening using human cells expressing IL-6 autocrine loop, we found that andrographolide, diterpenoid lactone isolated from traditional Chinese Indian medicinal plant Andrographis paniculata, could inhibit...
The mitogen-activated protein kinase (MAPK) pathways are important signal transduction conserved in essentially all eukaryotes, but haven't been subjected to functional studies the most cellulase-producing filamentous fungus Trichoderma reesei. Previous reports suggested presence of three MAPKs T. reesei: Tmk1, Tmk2, and Tmk3. By exploring phenotypic features reesei Δtmk3, we first showed elevated NaCl sensitivity repressed transcription genes involved glycerol/trehalose biosynthesis under...
ABSTRACT The RNA-editing enzyme ADAR1 is a double-stranded RNA (dsRNA) binding protein that modifies cellular and viral sequences by adenosine deamination. has been demonstrated to play important roles in embryonic erythropoiesis, response, interference. In human hepatitis virus infection, shown target suppress replication through dsRNA editing. It not clear whether this antiviral effect of common mechanism response infection. Here, we report proviral enhances vesicular stomatitis (VSV)...
The RNA-editing enzyme ADAR1 modifies adenosines by deamination and produces A-to-I mutations in mRNA. was recently demonstrated to function host defense embryonic erythropoiesis during fetal liver development. mechanisms for these phenotypic effects are not yet known. Here we report a novel of the regulation gene expression interacting with nuclear factor 90 (NF90) proteins, known regulators that bind antigen response recognition element (ARRE-2) have been stimulate transcription...
Obstructive sleep apnea is associated with voiding symptoms in humans and animals, yet its effects on the urinary tract are poorly understood. We examined bladder structure function, markers of oxidative damage redox survival pathway a rat model obstructive to identify changes.To we used oxycycler system create cyclical interruption breathing oxygen, thereby producing intermittent hypoxemia. Male Sprague Dawley® rats were divided into an apnea, sham treated control group 8 each. After 8-week...
To obtain highly sensitive and selective nanozymes, the ternary NiMo6/ZIF-67/C3N4 (n) nanocomposites were successfully fabricated in this work, namely, Anderson-type polyoxometalate (NH4)4[H6Ni(II)Mo6O24] (NiMo6) was encapsulated into customized cavities of ZIF-67 then fixed on graphitic carbon nitride (g-C3N4). By employing detection H2O2 ascorbic acid (AA) as a model reaction, exhibit excellent peroxidase-like activities, attributed to synergistic effect NiMo6, ZIF-67, g-C3N4, which (2)...
The exacerbation of IgA nephropathy (IgAN) is related to respiratory tract infection with hemolytic streptococcus (HS), but the mechanism unknown. In this study we investigated role chemokine ligand 20 (CCL20) in response effect T helper 17 (Th17) cells pathogenesis IgAN associated HS.Thirty mice were randomly divided into five groups: control (control), (IgAN), HS-infected (HS-IgAN), CCL20-treated (CCL20-IgAN), and HS infected (CCL20-HS-IgAN). induced lipopolysaccharide, carbon...
Clinical studies have reported a correlation between pelvic ischemia and voiding dysfunction in elderly men. The aim of this study was to identify compare prostate structural modifications cultured cells rabbit model after exposure hypoxia, oxidative stress, chronic ischemia. Cultured human smooth muscle (SMCs), epithelial (ECs), stromal (SCs) were incubated under normoxia, stress conditions by use computerized oxycycler system. We developed creating aorto-iliac arterial atherosclerosis....
Lower urinary tract symptoms (LUTS) are bothersome constellation of voiding in men and women as they age. Multiple factors comorbidities attributed to this problem but underlying mechanisms nonobstructive nonneurogenic detrusor overactivity, underactivity LUTS remain largely unknown. Our goal was characterize function patterns relation muscarinic receptors expression, nerve fiber density, neural ultrastructure chronic bladder ischemia.Iliac artery atherosclerosis ischemia were produced male...