A5003371331- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Molecular Biology Techniques and Applications
- Liver physiology and pathology
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Advanced Radiotherapy Techniques
- Nanoparticle-Based Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Microbial metabolism and enzyme function
- Esophageal Cancer Research and Treatment
- Cancer Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac tumors and thrombi
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- Eosinophilic Disorders and Syndromes
- Bladder and Urothelial Cancer Treatments
- Macrophage Migration Inhibitory Factor
- Drug Transport and Resistance Mechanisms
- Renal cell carcinoma treatment
- PARP inhibition in cancer therapy
- Tryptophan and brain disorders
Stanford University
2020-2025
Chinese Academy of Sciences
2017-2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Center for Excellence in Molecular Cell Science
2024
Stanford Medicine
2021
Royal Marsden NHS Foundation Trust
2020
Institute of Cancer Research
2020
University of California, Berkeley
2020
Shanghai Tenth People's Hospital
2020
Introduction: We previously identified niclosamide as a promising repurposed drug candidate for hepatocellular carcinoma (HCC) treatment. However, it is poorly water soluble, limiting its tissue bioavailability and clinical application. To overcome these challenges, we developed an orally bioavailable self-microemulsifying delivery system encapsulating (Nic-SMEDDS). Methods: Nic-SMEDDS was synthesized characterized physicochemical properties, in vivo pharmacokinetics absorption mechanisms,...
Heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) work together as a molecular chaperone complex to regulate the activity of multitude client kinases. These kinases belong wide array intracellular signaling networks that mediate multiple cellular processes including proliferation. As result, Hsp90 Cdc37 represent innovative therapeutic targets in various cancers (such leukemia, myeloma, hepatocellular carcinoma (HCC)) which their expression levels are elevated. Conventional...
LIF promotes self-renewal of mouse embryonic stem cells (mESCs), and in its absence, the differentiate. binds to receptor (LIFR) activates JAK-STAT3 pathway, but it remains unknown how complex triggers differentiation or self-renewal. Here, we report that LIFR cytoplasmic domain contains a within juxtamembrane region C-terminal region. The four SPXX repeats are phosphorylated by MAPK restrict STAT3 activation; is characterized 3K motif acetylated p300. In mESCs, acetyl-LIFR undergoes...
Glypican-3 (GPC3) is an attractive diagnostic marker for hepatocellular carcinoma (HCC). We previously reported the potential of 89Zr-labeled murine anti-GPC3 antibody (clone 1G12) immunoPET imaging HCC in orthotopic patient-derived xenograft (PDX) mouse models. now humanized by complementarity determining region (CDR) grafting, to allow its clinical translation human use. The engineered antibody, clone H3K3, retained comparable binding affinity and specificity GPC3. H3K3 was conjugated with...
Liver cancer, of which hepatocellular carcinoma (HCC) is the most common form, one lethal cancers worldwide. The five-year survival rate for HCC below 9%, can be attributed to late diagnosis and limited treatment options at stage. Therefore, safe efficient imaging strategies are urgently needed facilitate stage evaluation. development second near infrared window (NIR-II, 1000-1700 nm) fluorescence offers advantages enhanced resolutions, deeper penetration depth, less autofluorescence...
Clear cell renal carcinoma (ccRCC) is one of the most prevalent cancers in cancer patients. Currently, mTOR and vascular endothelial growth factor (VEGF) inhibitors are main targets clinical drugs used to treat ccRCC. However, major challenge with these treatments drug resistance. So far, mechanisms resistance not fully understood.We applied tumor-derived exosomes cells detect survival rate after co-treated anti-tumor drugs-TNFα, mammalian target rapamycin (mTOR) inhibitor or STAT3...
Dear Editor, The prognostic impact of postoperative radiotherapy (PORT) in esophageal cancer (EC) patients with negative lymph nodes has been investigated for decades. However, the data remain inconclusive and histological distinctions have not studied. Among EC, adenocarcinoma (AC) squamous cell carcinoma (SCC) are two most common types,1 but they differ epidemiological molecular features.2 How types alter therapeutic responses to PORT unknown. This study assessed relationship between...
Abstract Background Hepatocellular carcinoma (HCC) ranks third in cancer-related deaths worldwide, with limited therapeutic options. While niclosamide (NIC) has shown potential for repurposing HCC, its poor water solubility and low bioavailability limit efficacy, mechanisms of action are not yet fully elucidated. Methods We designed a water-soluble NIC prodrug (NIC-PS) evaluated efficacy through vitro vivo studies, including pharmacokinetic (PK) pharmacodynamic (PD) assays, HCC...
Background and Purpose: Hepatocellular carcinoma (HCC) ranks third in cancer-related deaths worldwide, with limited therapeutic options. While niclosamide (NIC) has shown potential for repurposing HCC, its poor water solubility low bioavailability limit efficacy, mechanisms of action are not yet fully elucidated. This study aimed to enhance NIC's by developing a water-soluble prodrug salt (NIC-PS) elucidate mechanisms, paving the way clinical translation. Experimental Approach: We designed...
Abstract LIF maintains self‐renewal growth in mouse embryonic stem cells (mESC) by activating STAT3, which translocates into nucleus for pluripotent gene induction. However, the ERK signaling pathway activated at large counteract with induction during growth. Here, it is reported that mESC STAT3 undergoes multivesicular endosomes (MVEs) translocation and subsequent secretion, LIF‐activated acetylated on K177/180 phosphorylated Y293 residues within N‐terminal coiled‐coil domain, responsible...
623 Serial monitoring for presence, number & characterization of circulating cancer cells (CCC) may provide valuable information that be relevant to prognosis and treatment outcomes breast patients (BCP). We conducted a serial blood sampling study at the University Maryland in BCP with stage 1–4 carcinoma. 15–20 ml venous were collected before start systemic therapy periodically thereafter processed using negative selection method double-gradient centrifugation magnetic cell sorting...