A5002825707- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Advanced Chemical Physics Studies
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Quantum, superfluid, helium dynamics
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- interferon and immune responses
- MicroRNA in disease regulation
- Liver physiology and pathology
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Spectroscopy and Quantum Chemical Studies
- Childhood Cancer Survivors' Quality of Life
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
Shanghai Institutes for Biological Sciences
2015-2025
Shanghai Institute of Nutrition and Health
2018-2025
Guangzhou Medical University
2018-2025
State Key Laboratory of Respiratory Disease
2020-2025
Chinese Academy of Sciences
2014-2023
Dalian Institute of Chemical Physics
2020-2023
Ningbo Medical Center Lihuili Hospital
2022
University of Chinese Academy of Sciences
2017-2021
Guangzhou Medical University Cancer Hospital
2018-2021
Dalian University
2021
An imbalance between normal adipogenesis and osteogenesis by mesenchymal stem cells (MSCs) has been shown to be related various human metabolic diseases, such as obesity osteoporosis; however, the underlying mechanisms remain elusive. We found that interaction osteopontin (OPN), an arginine-glycine-aspartate-containing glycoprotein, integrin αv/β1 plays a critical role in lineage determination of MSCs. Although OPN is well-established marker during osteogenesis, its MSC differentiation still...
Aqueous batteries (ABs) have attracted increasing attention because of their inherent safety and low cost. Nevertheless, hydrogen evolution reaction (HER) at the anode presents severe challenges for stable safe operation ABs. Instead passivating surface to hinder HER kinetics, a design strategy is proposed here suppress via alternating its thermodynamics pathway. Addition bond acceptor, dimethyl sulfoxide (DMSO) can delay onset potential by as much 1.0 V (on titanium mesh). Spectral...
Trace elements play important roles in human health, but little is known about their functions humoral immunity. Here, we show an role for iron inducing cyclin E and B cell proliferation. We find that iron-deficient individuals exhibit a significantly reduced antibody response to the measles vaccine when compared iron-normal controls. Mice with deficiency also attenuated T-dependent or T-independent antigen-specific responses. essential proliferation; both α-ketoglutarate inhibition could...
Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis (OA) "difficult-to-treat". Cartilage destruction is central to OA patho-etiology and mediated by matrix degrading enzymes. Here we report decreased expression of miR-17 in osteoarthritic chondrocytes its deficiency contributes progression. Supplementation exogenous or endogenous induction growth differentiation factor 5, effectively prevented simultaneously targeting pathological catabolic factors including...
Interleukin (IL) 17-producing T helper (Th17) cells play critical roles in the clearance of extracellular bacteria and fungi as well pathogenesis various autoimmune diseases, such multiple sclerosis, psoriasis, ulcerative colitis. Although a global transcriptional regulatory network Th17 cell differentiation has been mapped recently, participation epigenetic modifications process yet to be elucidated. We demonstrated here that histone H3 lysine-27 (H3K27) demethylation, predominantly...
Abstract Background Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored. Methods Proteomic quantification of lysine was performed human GC tissues and adjacent normal by mass spectrometry. The mRNA protein levels lactate dehydrogenase A (LDHA) were analyzed qRT-PCR western blot, respectively. expression K222-succinylated LDHA measured tissue microarray the K222...
Background: Chitinase-3-like protein 1 (CHI3L1) is overexpressed in various types of tumors, especially glioma, and contributes to tumor progression. However, the definite role CHI3L1 involved pathway glioma progression are not completely understood. Methods: expression human gliomas its association with patient survival was determined using enzyme-linked immunosorbent assay, western blot, immunohistochemistry, public databases. Single-cell RNA-seq used characterize landscape myeloid cells....
Abstract Histone methylation is a context-dependent modification that regulates gene expression, and the trimethylation of histone H3 lysine 27 (H3K27me3) usually induces silencing. Overcoming colorectal cancer (CRC) chemoresistance currently huge challenge, but relationship between H3K27me3 remains largely unclear. Here, we found levels positively correlated with metastasis-free survival CRC patients low level predicted poor outcome upon chemotherapeutic drug treatment. Oxaliplatin...
A subset of uterine natural killer cells promotes fetal growth through regulation growth-promoting factors by PBX1.
Abstract Oncogenic activation of KRAS and its surrogates is essential for tumour cell proliferation survival, as well the development protumourigenic microenvironments. Here, we show that deubiquitinase USP12 commonly downregulated in Kras G12D -driven mouse lung human non-small cancer owing to AKT-mTOR signalling. Downregulation promotes growth fosters an immunosuppressive microenvironment with increased macrophage recruitment, hypervascularization, reduced T activation. Mechanistically,...
Chronic inflammation promotes the tumorigenesis and cell stemness maintenance of colorectal cancer (CRC). However, bridge role long noncoding RNA (lncRNA) in linking chronic to CRC development progression needs better understanding. Here, we elucidated a novel function lncRNA GMDS-AS1 persistently activated signal transducer transcription activator 3 (STAT3) Wnt signaling tumorigenesis. Interleukin-6 (IL-6) Wnt3a induced expression, which was highly expressed tissues plasma patients....
Thymic epithelial cells (TECs) are the main component of thymic stroma, which supports T-cell proliferation and repertoire selection. Here, we demonstrate that Cbx4, a Polycomb protein is highly expressed in epithelium, has an essential non-redundant role organogenesis. Targeted disruption Cbx4 causes severe hypoplasia fetal thymus as result reduced thymocyte proliferation. Cell-specific deletion shows compromised thymopoiesis rooted defective compartment. Cbx4-deficient TECs exhibit...
Abstract Background Diagnostic biomarkers for the detection of colorectal cancers (CRCs) are lacking. Recent studies have demonstrated that circulating long non-coding RNAs potential to serve as cancers. We analyzed significance lncRNAs 91H, PVT-1 and MEG3 in CRC. Methods examined expression levels 13 candidate plasma 18 CRC patients 20 non-cancerous controls. Then, we validated our findings by determining six promising tissues normal tissues. Finally, evaluated clinical relevance 58 56...
A comparison of atomistic dynamics between microsolvated and unsolvated reactions can expose the precise role solvent molecules thus provide deep insight into how solvation influences chemical reactions. Here we developed first full-dimensional analytical potential energy surface F
Abstract Transforming growth factor beta (TGF β ) signaling in breast cancer is selectively associated with pulmonary metastasis. However, the underlying mechanisms remain unclear. Here we show that Bcl-3, a member of IκB family, serves as critical regulator TGF to modulate Bcl-3 expression was significantly metastasis-free survival patients. deletion inhibited migration and invasion cells vitro , well lung metastasis vivo . required for downstream genes are involved knockdown enhanced...
Abstract Glucocorticoids (GC) are widely used clinically, despite the presence of significant side effects, including glucocorticoid-induced osteoporosis (GIOP). While GC believed to act directly on osteoblasts and osteoclasts promote osteoporosis, detailed underlying molecular mechanism GC-induced is still not fully elucidated. Here, we show that lymphocytes play a pivotal role in regulating osteoporosis. We GIOP could be induced SCID mice lack T cells, but it re-established by adoptive...
Abstract Inflammasome activation is essential for host defence against invading pathogens, but also involved in various forms of inflammatory diseases. The processes that control inflammasome activity are thus important averting excessive immune responses and tissue damage. Here we show the deubiquitinase POH1 negatively regulates response triggered by activation. deficiency macrophages enhances mature IL-1β production without significant alterations priming ASC-caspase-1 In WT macrophages,...
Wnt/β-catenin signaling plays a critical role in colorectal cancer (CRC) tumorigenesis and the homeostasis of stem cells (CSCs), but its molecular mechanism remains unclear. B-cell lymphoma 3 (Bcl-3), member IκB family, is overexpressed CRC promotes tumorigenicity. Here, we report novel function Bcl-3 maintaining CSC by activating signaling. Silencing suppresses self-renewal capacity CSCs sensitizes to chemotherapeutic drugs through decrease Moreover, our data show that crucial component...
Dysfunction of the non-canonical NF-κB signaling pathway has been causally associated with numbers cancers and autoimmune diseases. However, specific inhibitors for this remain to be developed. Here we showed that structure-based cell-based screening yielded a potent small molecule targeting RelB inhibit pathway, while had no inhibitory effect on canonical pathway. Mechanistically, inhibitor directly interacted protein disrupted binding its target DNA, thus repressing transactivity genes....