A5102011489- Mast cells and histamine
- Immune Cell Function and Interaction
- Natural Compound Pharmacology Studies
- NF-κB Signaling Pathways
- Plant-derived Lignans Synthesis and Bioactivity
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical compounds biological activities
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactive Compounds
- Virus-based gene therapy research
- PI3K/AKT/mTOR signaling in cancer
- Natural product bioactivities and synthesis
- Polyamine Metabolism and Applications
- RNA Interference and Gene Delivery
- Saffron Plant Research Studies
- Fungal Biology and Applications
- Synthesis of Organic Compounds
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bioactive Compounds and Antitumor Agents
- Axial and Atropisomeric Chirality Synthesis
- Multicomponent Synthesis of Heterocycles
- Synthesis and Catalytic Reactions
- Phytochemistry and biological activity of medicinal plants
Hangzhou Normal University
2025
Beijing University of Civil Engineering and Architecture
2024
Ocean University of China
2021-2023
Nanjing University
2017-2022
Ministry of Education of the People's Republic of China
2022
Shanghai University of Traditional Chinese Medicine
2013-2021
Nanjing General Hospital of Nanjing Military Command
2017
Yeungnam University
2009-2014
Xiamen University
2014
Shanghai University
2014
Endoplasmic reticulum (ER) stress has been implicated in the pathogeneses of insulin resistance and type 2 diabetes, extracellular signal-regulated kinase (ERK) antagonist is an sensitizer that can restore muscle responsiveness both tunicamycin-treated cells diabetic mice. The present study was undertaken to determine whether chemical or genetic inhibition ER pathway targeting by ERK results metabolic benefits cells.ER induced L6 myotubes using tunicamycin (5 μg·mL(-1) ) thapsigargin (300...
Abstract FOXP3 + Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance. Disruption Foxp3 expression results generation instable Treg acquisition effector T-cell-like function. Here we report that E3 deubiquitinase USP21 prevents depletion at protein level restricts T-helper-1-like cells. Mice depleted Usp21 specifically display disorders characterized by spontaneous T-cell activation excessive T-helper type 1 (Th1) skewing into Th1-like stabilizes...
Andrographolide (Andro), a well-known labdane diterpenoid of Andrographis paniculata, has been reported to have anti-inflammatory effects in various inflammatory disease models. Despite ongoing efforts elucidate the mechanism Andro, its specific is not entirely clear. In this study, we confirmed inhibitory effect Andro on activity and studied depth find potential targets using lipopolysaccharide (LPS)-induced macrophages vitro dextran sulfate sodium (DSS)-induced mouse model acute colitis...
Asthma is a chronic and recurring airway disease, which related to mast cell activation. Many compounds derived from Chinese herbal medicine has promising effects on stabilizing cells decreasing inflammatory mediator production. Safranal, one of the active Crocus sativus, shows many anti-inflammatory properties. In this study, we evaluated effect safranal in ovalbumin (OVA)-induced asthma model. Furthermore, investigate effectiveness inhibiting production mediators passive systemic...
The aim of this work was to investigate the outcome an autologous dendritic cell (DC) vaccination in patients with stage II/III nasopharyngeal carcinomas (NPC). From 38 Epstein-Barr virus (EBV)-associated NPCs after a radiotherapy, 16 human leukocyte antigen-A2 (HLA-A2)-positive were enrolled and medicated DCs, which pulsed HLA-A2-restricted EBV-encoded latent membrane protein 2A (LMP2A) peptides. lymphocyte subsets, serum cytokines, EBV-DNA levels as well delayed-type hypersensitivity (DTH)...
Introduction:Crocus sativus (saffron) is widely used in China, Iran, and India for dyeing as a food additive medicinal plant. Safranal, one of the main constituents saffron, responsible its aroma has been reported to have anticancer, antioxidant, anti-inflammation properties. Objective: In this study, we investigated anti-inflammatory effects Safranal RAW264.7 cells, bone marrow-derived macrophages (BMDMs), dextran sulfate sodium (DSS)-induced colitis mice. Methods: toxicity was determined...
BackgroundAggregation of FcεRI activates a cascade signaling events leading to mast cell activation, followed by inhibitory signals that turn off the activating signals. However, overall view negative in cells is still incomplete. Although AMP-activated protein kinase (AMPK), which generally known as regulator energy metabolism, also associated with anti-inflammation, little about role AMPK cells.ObjectivesWe investigated and its regulatory mechanism cells.MethodThe roles FcεRI-dependent...
Trigonelline, one of the active compounds from
Here, we constructed a recombinant replication-competent adenovirus (rRCAd; AdAFPep/Rep) that expresses both E1A-13S driven by the α-fetoprotein (AFP) enhancer/promoter (AFPep) lacking any silencers in 5′-flanking region of AFP gene, and 55K-deleted E1B cytomegalovirus (CMV) promoter. We then examined feasibility gene therapy utilizing this virus for AFP-producing hepatocellular carcinoma (HCC). AdAFPep/Rep lysed all HCC cell lines (HuH7, HepG2, PLC/PRF/5 (P5)) at multiplicity infection...
Emodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined effect of emodin on production proinflammatory cytokines, such as, tumor necrosis factor (TNF)-<TEX>${\alpha}$</TEX> interleukin (IL)-6, in mouse bone marrow-derived mast cells (BMMCs) stimulated with phorbol 12-myristate 13-acetate (PMA) plus...
Background and Purpose Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract, an impaired immune response plays critical role in IBD. The current drugs therapies for IBD treatment are limited use, therefore, there need to find novel or this disease. We investigated effect cambogin mouse model dextran sulphate sodium (DSS)‐induced colitis whether attenuates inflammation via Treg‐cell‐mediated on response. Experimental Approach Chronic was...
The synthesis of NH-sulfoximines from sulfides has been first developed under mild conditions in an aqueous solution with surfactant TPGS-750-M as the catalyst at room temperature. In this newly process, a simple and convenient recycling strategy to regenerate indispensable hypervalent iodine(III) is used. resulting 1,2,3-trifluoro-5-iodobezene can be recovered almost quantitively mixture by liquid-liquid extraction then oxidized give corresponding species. This optimized procedure...
Previously, we reported that an ethanol extract of Ailanthus altissima has antiinflammatory activity in ovalbumin (OVA)-sensitized murine asthmatic model. To determine the biological compounds from this plant, luteolin-7-O-glucoside (L7G) was isolated and its antiasthmatic evaluated vivo L7G (10 to 100 mg/kg, per os (p.o.)) reduced amount eosinophil infiltration bronchoalveolar lavage (BAL) fluid a dose-dependent manner. In comparison, dexamethasone (5 p.o.), which used as positive control,...
Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, investigate its inhibitory mechanisms immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) a model IgE/Ag-mediated passive systemic anaphylaxis (PSA). inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) 5-lipoxygenase (5-LO) leukotriene C4 (LTC4)...
The aim of this study was to determine whether britanin, isolated from the flowers Inula japonica (Inulae Flos), modulates generation allergic inflammatory mediators in activated mast cells.To understand biological activity authors investigated its effects on prostaglandin D 2 (PGD ), leukotriene C 4 (LTC and degranulation IgE/Ag-induced bone marrow-derived cells (BMMCs).Britanin dose dependently inhibited generations PGD LTC BMMCs.Biochemical analyses IgE/Ag-mediated signaling pathways...