A5001761828- Natural Compound Pharmacology Studies
- Synthesis of Organic Compounds
- Ubiquitin and proteasome pathways
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive Compounds and Antitumor Agents
- Immune cells in cancer
- Phytochemistry and biological activity of medicinal plants
- Neurological Disease Mechanisms and Treatments
- Advanced Nanomaterials in Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Bioactive natural compounds
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Protease and Inhibitor Mechanisms
- GDF15 and Related Biomarkers
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Graphene and Nanomaterials Applications
- Ginkgo biloba and Cashew Applications
- Bioactive Compounds in Plants
Shanghai Jiao Tong University
2020-2025
Shanghai University of Traditional Chinese Medicine
2012-2025
Qingdao University
2023-2024
Ocean University of China
2016-2023
Tongren Hospital
2021-2022
State Council of the People's Republic of China
2015
Shanghai University
2014
Tsinghua University
2011
The metabolic program is altered during macrophage activation and influences polarization. Glutaminolysis promotes accumulation of α-ketoglutarate (αKG), leading to Jumonji domain-containing protein D3 (Jmjd3)-dependent demethylation at H3K27me3 M2 polarization macrophages. However, it remains unclear how αKG regulated This study shows that SENP1-Sirt3 signaling controls glutaminolysis, IL-4-stimulated Activation the axis augments through via glutaminolysis. We also identify glutamate...
Abstract Metabolic programming and mitochondrial dynamics along with T cell differentiation affect fate memory development; however, how to control metabolic reprogramming in development is unclear. Here, we provide evidence that the SUMO protease SENP1 promotes via Sirt3 deSUMOylation. SENP1-Sirt3 signalling augments deacetylase activity of Sirt3, promoting both OXPHOS fusion. Mechanistically, activates mitochondria, leading reduction acetylation metalloprotease YME1L1. Consequently,...
Andrographolide (Andro), a well-known labdane diterpenoid of Andrographis paniculata, has been reported to have anti-inflammatory effects in various inflammatory disease models. Despite ongoing efforts elucidate the mechanism Andro, its specific is not entirely clear. In this study, we confirmed inhibitory effect Andro on activity and studied depth find potential targets using lipopolysaccharide (LPS)-induced macrophages vitro dextran sulfate sodium (DSS)-induced mouse model acute colitis...
Exploring the mechanism through which berberine (Ber) reverses multidrug resistance (MDR) of breast cancer is great importance. Herein, we used methyl thiazolyl tetrazolium assay to determine drug and cytotoxicity Ber doxorubicin (DOX) alone or in combination on cell line MCF-7/DOXFluc. The results showed that could synergistically enhance inhibitory effect DOX tumor proliferation vitro, optimal ratio was Ber/DOX = 2:1. Using a luciferase reporter system combined with bioluminescence imaging...
Medicinal plants have long been an excellent source of pharmaceutical agents. Autophagy, a catabolic degradation process through lysosomes, plays important role in tumorigenesis and cancer therapy. Through screen designed to identify autophagic regulators from library natural compounds, we found that Guttiferone K (GUTK) can activate autophagy several cell lines. The objective this study is investigate the mechanism by which GUTK sensitizes cells death nutrient starvation condition. Cell...
Abstract Erlotinib resistance causes a high degree of lethality in non-small-cell lung cancer (NSCLC) patients. The expression and activation several receptor tyrosine kinases, such as JAK/STAT3, c-Met, EGFR, play important roles drug resistance. development kinase inhibitors is urgently required the clinic. Our previous study found that Gambogenic acid (GNA), small molecule derived from traditional Chinese medicine herb gamboge, induced cell death NSCLC lines through JAK/STAT3 inhibition....
Cambogin is a polycyclic polyprenylated acylphoroglucinol (PPAP) from the Garcinia genus, which has been used traditionally for cancer treatment across Southeastern Asia. In this study, we found that cambogin inhibited breast cell proliferation and induced apoptosis in vitro. activation of caspase-independent mitochondrial apoptotic pathway, as indicated by an increase ratio Bax/Bcl-2 nuclear translocation inducing factor (AIF). Two-dimensional gel electrophoresis mass spectrometry revealed...
Gemcitabine (GEM)-induced drug resistance is the major reason for failure of chemotherapy in pancreatic cancer (PC). In this study, we found that Oblongifolin C (OC) efficiently inhibited PC cell proliferation by inducing G0/G1 arrest and apoptosis. Also, our mechanism study demonstrated OC re-sensitized GEM-resistant cells through ubiquitin-proteasome-dependent degradation Src, then downregulating MAPK pathway. Knockdown Src plus resulted a greater inhibitory effect cells. contrast,...
Introduction:Crocus sativus (saffron) is widely used in China, Iran, and India for dyeing as a food additive medicinal plant. Safranal, one of the main constituents saffron, responsible its aroma has been reported to have anticancer, antioxidant, anti-inflammation properties. Objective: In this study, we investigated anti-inflammatory effects Safranal RAW264.7 cells, bone marrow-derived macrophages (BMDMs), dextran sulfate sodium (DSS)-induced colitis mice. Methods: toxicity was determined...
Four new dihydroxanthone derivatives (1–4), four tetrahydroxanthone (5–8), two xanthone (9 and 10), known caged tetrahydroxanthones were isolated from extracts of the leaves Garcinia oligantha by bioassay-guided fractionation. These structures compounds elucidated NMR MS spectroscopic data analysis, absolute configurations 1 5–7 determined electronic circular dichroism and/or single-crystal X-ray diffraction analysis. Compounds 6–9 shown to be unusual with an isopropyl group, which was...
Abstract Cell cycle re-entry by quiescent cancer cells is an important mechanism for progression. While high levels of c-MYC expression are sufficient cell re-entry, the modality to block expression, and subsequent limited. Using reversible quiescence rendered serum withdrawal or contact inhibition in PTEN null /p53 WT (LNCaP) mut (PC-3) prostate cells, we have identified a compound that able impede through c-MYC. Guttiferone K (GUTK) blocked resumption DNA synthesis preserved phase...
Bioassay-guided fractionation of the acetone extract leaves Garcinia nujiangensis resulted in isolation two new prenylated xanthones, nujiangexanthones A (1) and B (2), three polycyclic polyprenylated acylphloroglucinols, nujiangefolins A–C (3–5), 10 known related analogues. The structures compounds 1–5 were elucidated by interpretation their spectroscopic data. Compounds 3 4 are unusual acylphloroglucinols which enol hydroxy group forms a six-membered ring with benzene carbon. isolated...
Two new xanthones, cowaxanthones G (1) and H (2), 23 known analogues were isolated from an acetone extract of the leaves Garcinia cowa. The compounds evaluated for cytotoxicity against three cancer cell lines immortalized HL7702 normal liver cells, whereby 1, 5, 8, 15–17 exhibited significant cytotoxicity. Cell cycle analysis using flow cytometry showed that 5 induced arrest at S phase in a dose-dependent manner, 1 16 G2/M phase, 17 G1 while apoptosis. Moreover, autophagy by GFP-LC3 puncta...
In a cytotoxicity screen in serum-free medium, Guttiferone F showed strong growth inhibitory effect against prostate cancer cells.Prostate cells LNCaP and PC3 were treated with serum depleted medium. Sub-G1 phase distributions estimated flow cytometry. Mitochondrial disruption was observed under confocal microscope using Mitotracker Red staining. Gene protein expression changes detected by real-time PCR Western blotting. Ca(2+) elevation examined Fluo-4 staining fluorescence microscope....
Abstract Tumor metastasis is the main cause of cancer-related patient death. In this study, we performed a wound healing migration screen to search for metastatic inhibitor within our library natural compounds. We found that oblongifolin C (OC), compound extracted from Garcinia yunnanensis Hu, an effective in human esophageal squamous carcinoma Eca109 cells. The transwell and matrigel invasion assay results also showed OC inhibits cells HepG2 can increase expression tubulin, indicating via...