A5100632523- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Flavonoids in Medical Research
- Berberine and alkaloids research
- Plant-based Medicinal Research
- Ginseng Biological Effects and Applications
- Medicinal Plant Pharmacodynamics Research
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Studies
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Natural Compounds in Disease Treatment
- Medical Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Infant Nutrition and Health
- Alkaloids: synthesis and pharmacology
- Inflammation biomarkers and pathways
- Gastrointestinal disorders and treatments
- Acute Ischemic Stroke Management
- Hepatitis C virus research
- Pharmacogenetics and Drug Metabolism
- Educational Reforms and Innovations
Aerospace Information Research Institute
2025
Chinese Academy of Sciences
2025
General Hospital of Shenyang Military Region
2022-2024
Jilin Agricultural University
2024
Shanghai University of Traditional Chinese Medicine
2013-2023
Jiangxi University of Traditional Chinese Medicine
2022
Second Affiliated Hospital of Zhejiang University
2022
Shanghai University of Medicine and Health Sciences
2021
Xi'an University of Science and Technology
2018-2021
Shanghai University
2012-2021
<h3>Importance</h3> Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; however, robust evidence in patients with stroke is lacking. <h3>Objective</h3> To assess the efficacy RIC for acute moderate stroke. <h3>Design, Setting, Participants</h3> This multicenter, open-label, blinded–end point, randomized trial including 1893 was conducted at 55...
Dual antiplatelet therapy has been demonstrated to be superior single in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect mild moderate is lacking.
Objective: To assess the feasibility and safety of magnetic-controlled capsule endoscopy (MCE) system for examination human stomach.Methods: This pilot study enrolled 34 healthy volunteers.All subjects swallowed MCE gas-producing powder gastric distention.An external robot was used to generate magnetic field manipulate inside stomach.The primary measurements included safety, preparation, maneuverability visualization mucosa.Results: Gastric preparation well accepted by there were no adverse...
In vehicular ad hoc network (VANET), a single-hop transmission is usually unable to cover all the intended receivers due limited radio range. Therefore, multi-hop broadcast services should be supported and then next hop selection becomes critical problem. However, conventional routing schemes cannot promise good enough reliability efficiency for VANET. this paper, we propose reliable scheme based on mobility prediction (RB-MP) achieve an efficient broadcast. This selects rebroadcast nodes,...
Microglia are believed to participate in the mediation of neurodegeneration through producing a variety cytotoxic factors upon activation. Pharmacological intervention microglial activation may therefore exert neuroprotective effect. In exploring pharmacological agents that can affect activation, we found this study triptolide possesses powerful inhibitory influence over microglia. Pretreatment with was able dose-dependently reduce lipopolysaccharide (LPS)-induced nitrite accumulation and...
Bioassay-guided fractionation of the acetone extract leaves Garcinia nujiangensis resulted in isolation two new prenylated xanthones, nujiangexanthones A (1) and B (2), three polycyclic polyprenylated acylphloroglucinols, nujiangefolins A–C (3–5), 10 known related analogues. The structures compounds 1–5 were elucidated by interpretation their spectroscopic data. Compounds 3 4 are unusual acylphloroglucinols which enol hydroxy group forms a six-membered ring with benzene carbon. isolated...
A rapid and high-sensitivity liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for simultaneous determination of nine active constituents (baicalin, baicalein, wogonoside, wogonin, scutellarin, berberine, coptisine, ginsenoside Rb1 Re) in rat plasma after oral administration Banxia xiexin decoction (BXD). Biological samples were processed wtih acetone-ethyl acetate (4:1, v/v). The mobile phase consisted methanol water (containing 0.1% formic acid) with gradient...
Arable land is fundamental to agricultural production and a crucial component of ecosystems. However, its complex texture distribution in remote sensing images make it susceptible interference from other cover types, such as water bodies, roads, buildings, complicating accurate identification. Building on previous research, this study proposes an efficient lightweight CNN-based network, U-MGA, address the challenges feature similarity between arable non-arable areas, insufficient...
Jatrorrhizine, a protoberberine alkaloid derived from Coptis chinensis, is currently under investigation as natural gastric prokinetic drug candidate. In vitro and in vivo studies were conducted to characterize its pharmacokinetics metabolism. After intravenous administration, the plasma concentration kinetics major metabolites rats investigated. The metabolic kinetics, key cytochrome P450 enzymes UDP-glucuronosyltransferase isoforms (UGTs) of jatrorrhizine studied rat liver microsomes...
Rhizoma coptidis is a rhizome commonly used in traditional Chinese medicine. After oral administration of rhizoma extract, the plasma concentrations its effective alkaloid constituents are so low that their systemic therapeutic actions cannot be explained. This study aimed to investigate influence lipopolysaccharide (LPS) on pharmacokinetics alkaloids. Pharmacokinetic experiments were performed with rats; both vitro absorption and efflux carried out everted rat gut sacs, whereas metabolism...
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of 12 constituents Gegen Qinlian Decoction (GQD), namely puerarin, daidzein, baicalin, wogonoside, wogonin, liquiritin, liquiritigenin, berberine, jatrorrhizine, palmatine, coptisine glycyrrhetic acid, in rat plasma. The plasma samples were spiked with internal standard (IS) carbamazepine acidified HCl extracted by liquid-liquid extraction ethyl acetate....
Abstract A quick and effective workflow based on ultra‐performance liquid chromatography coupled with electron spray ionization LTQ‐Orbitrap mass spectrometry (UPLC‐LTQ‐Orbitrap MS) was established for compositional analysis screening of the characteristic compounds three species Atractylodes rhizome quality evaluation. This technique employed to determine seven main components in samples. Ultimately, 78 constituents were identified; these, selected discrimination, comprising atractylodin...
Chinese Herbal Medicines (CHM) have been used in disease prevention and treatment for centuries China. A number of anti-breast cancer agents isolated from CHM recently, showed very interesting structures, although some the mechanism action is not quite clear. These unique chemical structures could be an important information resource new drugs' design discovery. This review summarizes these findings on CHM.
ABSTRACT Jatrorrhizine, one of the protoberberine alkaloids derived from plant Coptis chinensis , is expected to be developed as a new gastric prokinetic drug, but its metabolic characteristics in humans remain unknown. This study characterized phase I and II metabolites, kinetics, cytochrome P450 (CYP) UDP‐glucuronosyltransferase (UGT) enzymes responsible for metabolism jatrorrhizine human liver microsomes (HLMs). Chemical inhibition HLMs by recombinant CYP or UGT were employed determine...
Gegenqinlian decoction (GQD) is a famous traditional medicine recipe. It composed of four herbs including Radix Puerariae (GG), Scutellariae (HQ), Rhizoma Coptidis (HL) and Glycyrrhizae (GC), which widely used for treating gastro-intestinal disorders in the clinical practice Traditional Chinese (TCM). The aim this study was to compare pharmacokinetics puerarin daidzein rats following oral administration Decoction extract. Thus, sensitive selective liquid chromatography/tandem mass...