A5073730157- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Drug-Induced Adverse Reactions
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Mast cells and histamine
- Neonatal Respiratory Health Research
- Delphi Technique in Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacovigilance and Adverse Drug Reactions
- Eosinophilic Disorders and Syndromes
- Dermatology and Skin Diseases
- Rheumatoid Arthritis Research and Therapies
- Mesenchymal stem cell research
- Pneumocystis jirovecii pneumonia detection and treatment
- Helicobacter pylori-related gastroenterology studies
- Drug-Induced Hepatotoxicity and Protection
- Cytokine Signaling Pathways and Interactions
University of Ulsan
2016-2025
Asan Medical Center
2016-2025
Ulsan College
2016-2025
Royal Brompton Hospital
2023
Hallym University
2020
Hallym University Dongtan Sacred Heart Hospital
2020
ORCID
2019
Ministry of Health and Welfare
2012
Johns Hopkins University
2008-2010
Johns Hopkins Medicine
2008
BackgroundClinical characteristics of the international population with severe asthma are unknown. Intercountry comparisons hindered by variable data collection within regional and national registries. We aimed to describe demographic clinical patients treated in services United States, Europe, Asia-Pacific region.MethodsThe International Severe Asthma Registry retrospectively prospectively collected (≥ 18 years old), receiving Global Initiative for (GINA) Step 5 treatment or remaining...
Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative asthmatics, it is important to investigate precise intracellular mechanism by which development immunity, rather than immune tolerance and progression airway inflammation, induced. In this article, we suggest that protein tyrosine phosphatases, as negative regulators, antioxidant enzymes such peroxiredoxins can be regulated during signaling.
Asthma is a heterogeneous airway disease with various clinical phenotypes. It crucial to clearly identify phenotypes achieve better asthma management. We used cluster analysis classify the groups of 724 asthmatic patients from Cohort for Reality and Evolution Adult in Korea (COREA), 1843 subjects another independent Korean cohort Soonchunhyang University Genome Research Centre (SCH) (Bucheon, Republic Korea). Hierarchical was performed by Ward's method, followed κ-means analysis. Cluster...
Aims: Cellular senescence and its secretory phenotype (senescence-associated [SASP]) develop after long-term expansion of mesenchymal stromal cells (MSCs). Further investigation this is required to improve the therapeutic efficacy MSC-based cell therapies. In study, we show that positive feedback between SASP inherent processes plays a crucial role in umbilical cord blood-derived MSCs (UCB-MSCs). Results: We found monocyte chemoattractant protein-1 (MCP-1) was secreted as dominant component...
Abstract Background The clinical manifestations of severe asthma are heterogeneous. Some individuals with develop irreversible fixed airway obstruction, which is associated poor outcomes. We therefore investigated the factors obstruction in Korean patients asthma. Methods Severe from a adult cohort were divided into two groups according to results serial pulmonary function tests. One group had (FAO) [forced expiratory volume 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7, n =...
Oxidative stress is implicated in the pathogenesis of allergic asthma and remains an attractive target for prevention disease. Herein, we investigated anti‐inflammatory effects apocynin, a NADPH oxidase (NOX) inhibitor, both vitro vivo allergen‐induced experimental mediated by Th2 hyperresponsiveness. Apocynin showed potential antioxidant activities inhibitory on activation redox‐sensitive transcription factors, such as NF‐κB AP‐1, induced pro‐inflammatory stimuli, TNF‐α, lipopolysaccharide...
Purpose: To assess the feasibility of xenon ventilation computed tomography (CT) for evaluating abnormality in asthmatics. Materials and Methods: Twenty-two, stable asthmatics (M:F = 10:12; mean age, 57.6) were included. Single-phase, whole-thorax, dual-energy CT was performed using dual-source (Somatom Definition, Siemens) after subjects had inhaled 30% 90 seconds. Parameters include 512 × matrix; 14 1.2 mm collimation; 40/140 eff. mAs at 140/80 kV; 0.45 pitch; 0.33 seconds rotation time....
Eosinophilic inflammation is a key component of severe asthma (SA). However, there has been no reliable serum biomarker for the eosinophilic SA. We hypothesized that eosinophil-derived neurotoxin (EDN) could predict SA in adult asthmatics.Severe asthmatics (n = 235), nonsevere 898), and healthy controls 125) were enrolled from Ajou University Hospital, South Korea. The levels EDN periostin measured by enzyme-linked immunosorbent assay compared between asthmatics. Their associations with...
The prevalence and burden of asthma is increasing worldwide. In this study, we analyzed 3 different Korean national health survey datasets to determine the general features adult in Korea obtain basic information that would support future strategies for better management asthma.The surveys used study included National Health Nutrition Examination Survey (KNHANES), Community (KCHS) Insurance Service-National Sample Cohort (NHIS-NSC). We investigated annual prevalence, evaluating rate risk...
Purpose: Although mild to moderate asthma is much more common, the morbidity and mortality of severe are higher.This study was performed identify analyze clinical characteristics in Korea.Methods: We registered patients with refractory into Severe Asthma Registry supported by Work Group Korean Academy Asthma, Allergy Clinical Immunology.Patients were enrolled since 2010 from 15 university hospitals nationwide Korea.Severe defined according modified European Respiratory Society/American...
Abstract Background Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of severe population, many need be evaluated understand clinical features outcomes in order facilitate personalised targeted The International Asthma Registry (ISAR) is multi-country registry project initiated aid this endeavour. Methods ISAR multi-disciplinary initiative benefitting from combined experience Steering Committee (ISC; comprising 47 clinicians...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease of unknown cause which leads to alveolar epithelial cell apoptosis followed by basement membrane disruption and accumulation extracellular matrix, destroying the architecture. Oxidative stress involved in development injury, inflammation, fibrosis. stress-mediated (AEC) suggested be key process pathogenesis IPF. Therefore, present study investigated whether grape seed proanthocyanidin extract (GSPE) could...
Adverse drug reactions (ADRs) are escalating, and their socioeconomic burden is increasing. However, large-scale prospective studies investigating ADRs during hospitalization rare in Korea. We prospectively investigated the incidence, characteristics, economic of hospitalized patients based on electronic medical records (EMRs).Among admitted to three hospitals from October 2016 2017, 5,000 were randomly selected observed hospitalization. Research nurses monitored detected who had symptoms,...
Abstract Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as heart, is crucial for normal pregnancy. However, mechanism through which influences of organs remains unclear. Trophoblasts fuse to form multinucleated syncytiotrophoblasts (SynT), primarily make up materno-fetal interface. We discovered that endogenous progesterone immunomodulatory binding factor 1 (PIBF1) vital...
Reactive oxygen species (ROS) performs a pivotal function as signaling mediator in receptor-mediated signaling. However, the sources of ROS this have yet to be determined, but may include lipoxygenases (LOXs) and NADPH oxidase. The stimulation lymphoid cells with TNF-alpha, IL-1beta, LPS resulted significant production NF-kappaB activation. Intriguingly, these responses were markedly abolished via treatment LOXs inhibitor nordihydroguaiaretic acid (NDGA). We further examined vivo...
AMP-activated protein kinase (AMPK) not only functions as an intracellular energy sensor and regulator, but is also a general of oxidative stress. Furthermore, there recent evidence that it participates in limiting acute inflammatory reactions, apoptosis cellular senescence. Thus, may oppose the development chronic obstructive pulmonary disease.To investigate role AMPK cigarette smoke-induced lung inflammation emphysema we first compared smoking polyinosinic-polycytidylic acid...