A5101624294- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Respiratory and Cough-Related Research
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Pediatric health and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Inhalation and Respiratory Drug Delivery
- Eosinophilic Esophagitis
- Pharmacovigilance and Adverse Drug Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Smoking Behavior and Cessation
- Eosinophilic Disorders and Syndromes
- Marine and coastal plant biology
- Health and Wellbeing Research
- Graphene and Nanomaterials Applications
- IL-33, ST2, and ILC Pathways
- Algal biology and biofuel production
- Tuberculosis Research and Epidemiology
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Occupational exposure and asthma
Chung-Ang University Hospital
2013-2025
Incheon National University
2023-2025
Chung-Ang University
2016-2025
Seoul National University
2000-2024
Dunsan Korean Medicine Hospital
2024
Novartis (South Korea)
2024
Seoul National University Hospital
2001-2023
Korea University Medical Center
2023
CHA University
2021
Moffitt Cancer Center
2019
Purpose To determine the incidence and risk factors of immediate hypersensitivity reactions to gadolinium-based magnetic resonance (MR) contrast agents. Materials Methods Institutional review board approval a waiver informed consent were obtained. A retrospective study patients who had been given MR media between August 2004 July 2010 was performed by reviewing their electronic medical records. In addition data on reaction, kinds demographic including age, sex, comorbidity collected. compare...
Recent investigations suggest genetic susceptibility of allopurinol-induced severe cutaneous adverse reactions (SCARs). However, the strength association was variable according to phenotypes and ethnic backgrounds. To explore markers for SCARs in Koreans, we genotyped human leukocyte antigen (HLA) class I alleles 25 cases (20 drug-induced hypersensitivity syndrome five Stevens–Johnson syndrome/toxic epidermal necrolysis) 57 patients tolerant allopurinol. Frequencies B*5801 [92.0 vs. 10.5%,...
The therapeutic potential of human multipotent mesenchymal stromal cells, especially adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety infusion hASC in human. Recently, we have experienced pulmonary embolism and infarct among family members who taken multiple infusions intravenous autologous therapy. A 41-year-old man presented with chest pain for one month. Chest CT showed artery at right lung. Serum D-dimer was 0.8 μg/mL (normal; 0-0.5...
Background Multicenter studies may be required for establishing guidelines safe usage of iodinated contrast media (ICM). Purpose To identify the prevalence, patterns, risk factors, and preventive measures ICM-related hypersensitivity reactions (HSRs). Materials Methods Between March 2017 October 2017, a total 196 081 patients who underwent ICM administration were enrolled from seven participating institutions. The occurrence HSRs baseline patient information recorded. χ2 Student t test...
Background. Although allopurinol is a very effective urate-lowering drug for complicated hyperuricemia, in some patients, it can induce severe cutaneous adverse reactions (SCARs). Recent investigations suggest that HLA-B*5801 strong marker allopurinol-induced SCARs, especially the population with high frequency of HLA-B*5801. Korea one countries which only subtype HLA-B58 Korean population. Objective. This study was conducted to find out incidence hypersensitivity on patients chronic renal...
Anaphylaxis is the most severe form of radiocontrast media (RCM) induced hypersensitivity and can be life-threatening if profound hypotension combined. With increased use iodine based RCM, related rapidly growing. However, clinical characteristics risk factors RCM anaphylaxis accompanied by (anaphylactic shock) are not clearly defined. This study was performed to investigate anaphylactic shock value skin testing identify causative agents in affected patients.We analyzed data monitored an...
Highly efficient ITO-free polymeric electronic devices were successfully demonstrated by replacement of the ITO electrode with a solution-processed PEDOT:PSS containing Ag nanoparticles (NPs). Polymer solar cells (PSCs) and light emitting diodes (PLEDs) fabricated based on poly(5,6-bis(octyloxy)-4-(thiophen-2-yl)benzo[c][1,2,5]thiadiazole) (PTBT):PC61BM Super Yellow as photoactive layer, respectively. The surface plasmon resonance (SPR) effect improved electrical conductivity NPs clearly...
Summary Background Although asthma is a common cause of morbidity in adults, relatively few objectively measured population studies prevalence adult populations have been conducted. Objective To evaluate the asthma, based on both questionnaire and methacholine bronchial provocation test, to determine risk factors an population. Methods A total 2467 who were randomly selected from metropolitan urban, non‐metropolitan urban rural areas, responded modified ISAAC questionnaire, underwent tests...
<h3>Background</h3> Uncontrolled diabetes, unlike controlled is associated with an impaired immune response. However, little known about the impact of status diabetes control on clinical features and treatment outcomes in patients pulmonary TB (PTB). We conducted this study to evaluate whether influences manifestations responses PTB. <h3>Methods</h3> A multicentre prospective was performed between September 2012 2014. The were categorised into three groups according glycated haemoglobin...
Purpose: Although mild to moderate asthma is much more common, the morbidity and mortality of severe are higher.This study was performed identify analyze clinical characteristics in Korea.Methods: We registered patients with refractory into Severe Asthma Registry supported by Work Group Korean Academy Asthma, Allergy Clinical Immunology.Patients were enrolled since 2010 from 15 university hospitals nationwide Korea.Severe defined according modified European Respiratory Society/American...
Inhaled corticosteroids (ICS) could increase both the risk of coronavirus disease 2019 (COVID-19) and experiencing poor outcomes. To compare clinical outcomes between ICS users nonusers, COVID-19-related claims in Korean Health Insurance Review Assessment database were evaluated. evaluate susceptibility to COVID-19 among patients with COPD or asthma, a nested case-control study was performed using same database. In total, 7341 confirmed have COVID-19, including 114 7227 nonusers. Among 5910...
Abstract Although cigarette smoking is known to exacerbate asthma, only a few clinical asthma studies have been conducted involving smokers. Here we show, by comparing paired sputum and blood samples from non-smoking patients with that associates significantly higher frequencies of pro-inflammatory, natural-cytotoxicity-receptor-non-expressing type 3 innate lymphoid cells (ILC3) in the memory-like, CD45RO-expressing ILC3s blood. These ILC3 positively correlate circulating neutrophil counts...
Abstract Introduction After intensive tobacco control efforts in recent decades, the prevalence of active smoking has decreased. However, hazardous effect indirect exposure to cigarette smoke is often underestimated, especially children. We aimed investigate parental on respiratory morbidity children parents who by evaluating relationship between behavior and children's symptoms. Methods conducted a cross‐sectional follow‐up study 31,584 aged 6–11 an urban community Anyang City, Korea. The...
sal congestion, the most common symptom, and long-term use can lead to weight gain in some patients.Thus, patients who do not want receive such medication often seek complementary alternative therapies effects of which have yet been verified.Ginseng has long used as an herbal throughout East Asia, including Korea, is a member scientific family Araliaceae, genus Panax.Of species ginseng,
<b><i>Background:</i></b> Severe cutaneous adverse reactions (SCARs) include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia systemic symptoms (DRESS). SJS TEN (SJS/TEN) DRESS are thought to be different diseases; however, they share some clinical laboratory features. Although SCORTEN serves as an excellent prognostic marker for SJS/TEN, there is still a need development of other markers SCARs....
Few studies have investigated the incidence of anaphylaxis induced by individual or structurally similar cephalosporins. The aims study were to assess cephalosporin-induced and evaluate clinical efficacy screening skin tests.In this retrospective cohort study, we obtained information on total cephalosporin use in intravenous recipients 12 general hospitals between 2013 2015. Cephalosporins divided into 4 groups according side-chain structures. was assessed for each cephalosporin, generation,...
Severe asthma is associated with high morbidity and healthcare utilization; however, treatment options for these patients are limited. This study aimed to determine the therapeutic effects of biologics in clinical practice. multicenter, retrospective cohort included 136 who received at least 4 months between September 2017 July 2022 25 medical centers affiliated Korean Asthma Registry (KoSAR). The evaluated effects, including acute exacerbation rates, maintenance oral corticosteroid dosages,...
Objectives Pulmonary tuberculosis (TB) can affect lung function, but studies regarding long-term follow-up in patients with no sequelae on chest X-ray (CXR) have not been performed. We evaluated functional impairment and persistent respiratory symptoms those prior pulmonary TB residual CXR, determined risk factors for airflow obstruction. Methods used data from adults aged ≥ 40 years the annual Korean National Health Nutrition Examination Surveys conducted between 2008 2012. P values...
Abstract Purpose Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but serious condition that systematically damages various internal organs through T‐cell–mediated immunological drug reactions. We aimed to investigate whether clinical manifestations of DRESS differ according culprit drugs. Methods retrospectively analyzed data from 123 patients probable/definite based on the RegiSCAR criteria (January 2011 July 2016). The were obtained Korean Severe Cutaneous...
Severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia systemic symptoms (DRESS) to antiepileptic (AED), are rare, but result in significant morbidity mortality. We investigated the major culprit drugs, clinical characteristics, course outcomes of AED-induced SCARs using a nationwide registry Korea.A total 161 patients from 28 referral hospitals were analyzed. The causative AEDs, organ...