A5085059045- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Biochemical Acid Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Bone Metabolism and Diseases
- Coronary Interventions and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- Parathyroid Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Metabolism and Genetic Disorders
- Advanced MRI Techniques and Applications
- Muscle metabolism and nutrition
- Folate and B Vitamins Research
- Retinal Diseases and Treatments
- Diabetes Management and Research
Asan Medical Center
2013-2024
University of Ulsan
2014-2024
Ulsan College
2014-2024
Job Performance Systems (United States)
2015
Bridge University
2015
Harvard University
2011
Brigham and Women's Hospital
2011
Kyungpook National University
2005-2009
Keimyung University
2009
Chungnam National University
2009
The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access the databases within Korean Diabetes Association for benefit of subjects with diabetes. Here, we present history, structure, contents, and way use data procurement in (NHI) system researchers.The NHIS Korea is a single-payer program mandatory all residents Korea. three main healthcare programs NHI, Medical Aid, long-term care insurance (LTCI) 100% coverage population. has adopted...
In 2014, the National Health Insurance Service (NHIS) signed a memorandum of understanding with Korean Diabetes Association to provide limited open access its databases for investigating past and current status diabetes management. NHIS include entire population; therefore, it can be used as population-based nationwide study various diseases, including complications. This report presents how we established analytic system nation-wide studies using database follows: selection population...
OBJECTIVE—Adiponectin is an important adipocytokine that improves insulin action and reduces atherosclerotic processes. The plasma adiponectin level paradoxically reduced in obese individuals, but the underlying mechanism unknown. This study was undertaken to test hypothesis mitochondrial function linked synthesis adipocytes. RESEARCH DESIGN AND METHODS—We examined effects of rosiglitazone measures increase or decrease on synthesis. We also molecular by which changes affect...
There is an apparent overlap between areas in the USA where herbicide, atrazine (ATZ), heavily used and obesity-prevalence maps of people with a BMI over 30. Given that herbicides act on photosystem II thylakoid membrane chloroplasts, which have functional structure similar to mitochondria, we investigated whether chronic exposure low concentrations ATZ might cause obesity or insulin resistance by damaging mitochondrial function. Sprague-Dawley rats (n = 48) were treated for 5 months (30 300...
Hyperhomocystinemia is a modifiable risk factor for osteoporosis and fracture. Physiologic concentrations of Hcy directly activate osteoclast formation activity through stimulation p38 MAPK integrin beta3. The effects were mediated by generation intracellular ROS.Hyperhomocysteinemia its related bone fractures. It has been reported that resorption turnover rate increased in hyperhomocystinemia. Using mouse marrow cells, we examined the direct homocysteine (Hcy) on activity.Osteoclast was...
Abstract Fatty liver is common in obese subjects with insulin resistance. Hepatic expression of sterol regulatory element binding protein-1c (SREBP-1c), which plays a major role hepatic steatosis, regulated by multiple factors, including insulin, adenosine monophosphate–activated protein kinase (AMPK), X receptors (LXRs), and specificity 1. Alpha-lipoic acid (ALA), naturally occurring antioxidant, has been shown to decrease lipid accumulation skeletal muscle activating AMPK. Here we show...
Non-alcoholic fatty liver disease is the most common form of chronic in industrialized countries. Recent studies have highlighted association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation mitochondrial acid oxidation (FAO) removal reactive oxygen species through catalase or plasmalogen synthesis. Statins known prevent steatosis non-alcoholic steatohepatitis (NASH),...
Leptin and insulin are important anorexigenic hormones acting on the hypothalamus. However, most obese humans animals have reduced hypothalamic responses to leptin insulin. Increased endoplasmic reticulum (ER) stress has been shown cause resistance in livers of animals. In present study, we investigated a role ER development central resistance. Intracerebroventricular (ICV) administration inducer thapsigargin (TG) increased food intake body weight. Furthermore, ICV or intra-hypothalamic TG...
Coupling is the process that links bone resorption to formation in a temporally and spatially coordinated manner within remodeling cycle. Several lines of evidence point critical roles osteoclast-derived coupling factors regulation osteoblast performance. Here, we used fractionated secretomic approach identified axon-guidance molecule SLIT3 as clastokine stimulated migration proliferation by activating β-catenin. also inhibited suppressing osteoclast differentiation an autocrine manner. Mice...
The prevalence of metabolic syndrome has markedly increased worldwide. However, studies in the United States show that it remained stable or slightly declined recent years. Whether this applies to other countries is presently unclear.We examined trends and its components Korea.The was estimated adults aged >30 years from Korean National Health Insurance Service data 2009 2013. revised Cholesterol Education Program criteria were used define syndrome.Approximately 10 million individuals...
Objective Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined. Sphingolipids and free cholesterol (FC) mediate injury, their link NASH has been explored. We examined role sphingomyelin synthases (SMSs) that generate (SM) diacylglycerol (DAG) pyroptosis, specific form programmed cell death associated with inflammasome activation, NASH. Design Wild-type C57BL/6J mice were fed high fat diet (HFHCD) to...
Calcification of the aortic valve leads to increased leaflet stiffness and consequently development calcific disease. However, underlying molecular cellular mechanisms calcification remain unclear. Here, we identified that dipeptidyl peptidase-4 (DPP-4, also known as CD26) increases valvular promotes disease progression.We obtained tissues from humans murine models (wild-type endothelial nitric oxide synthase-deficient-mice) cultured interstitial cells (VICs) cusps. We induced osteogenic...
Although macroautophagy/autophagy deficiency causes degenerative diseases, the deletion of essential autophagy genes in adipocytes paradoxically reduces body weight. Brown adipose tissue (BAT) plays an important role weight regulation and metabolic control. However, key cellular mechanisms that maintain BAT function remain poorly understood. this study, we showed global or brown adipocyte-specific pink1, a Parkinson disease-related gene involved selective mitochondrial (mitophagy), induced...
Lipid accumulation in nonadipose tissues is closely related to the development of type 2 diabetes obese subjects. We examined potential preventive effect peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ stimulation on diabetes-prone OLETF rats. Chronic administration a PPAR-α agonist (0.5% [wt/wt] fenofibrate) or (3 mg · kg−1 day−1 rosiglitazone) completely prevented glycosuria. Pancreatic islets from untreated rats underwent sequential hypertrophy atrophy, which was by chronic...
Lipid accumulation in vascular endothelial cells may play an important role the pathogenesis of atherosclerosis obese subjects. We showed previously that alpha-lipoic acid (ALA) activates AMP-activated protein kinase (AMPK) and reduces lipid skeletal muscle rats. Here, we investigated whether ALA improves dysfunction rats by activating AMPK cells.Endothelium-dependent relaxation was impaired, number apoptotic higher aorta compared with control In addition, triglyceride peroxide levels were...
OBJECTIVE The angiopoietin-like protein 4 (Angptl4)/fasting-induced adipose factor (Fiaf) is known as a regulator of peripheral lipid and glucose metabolism. In the present study, we investigated physiological role Angptl4 in central regulation body weight homeostasis. RESEARCH DESIGN AND METHODS Hypothalamic expression levels were measured using immunoblot assay during feeding manipulation or after administration leptin, insulin, nutrients. effects on food intake, weight, energy expenditure...
The metabolic syndrome (MS) is associated with increased life-time risk for atherosclerotic cardiovascular disease. While some reports suggest that MS and/or insulin resistance low serum free T4 (FT4) level in euthyroid subjects, this remains a controversial issue.To clarify the association of FT4 presence and its components healthy subjects.For 44,196 subjects (including 25,147 males) not taking thyroid hormone or antithyroid-drug without liver renal disease who participated routine health...