A5014852642- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Glaucoma and retinal disorders
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Retinal Diseases and Treatments
- Hematopoietic Stem Cell Transplantation
- Infective Endocarditis Diagnosis and Management
- Health disparities and outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Ischemic Stroke Management
- Gastric Cancer Management and Outcomes
- Corneal surgery and disorders
- Acute Myeloid Leukemia Research
- Cancer, Lipids, and Metabolism
- Retinal Imaging and Analysis
- SARS-CoV-2 and COVID-19 Research
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
Asan Medical Center
2016-2025
University of Ulsan
2016-2025
Ulsan College
2016-2025
University of Missouri Health System
2025
University of Missouri
2025
Women's Health Research Institute
2025
Cancer Research And Biostatistics
2015-2022
CHA Bundang Medical Center
2022
Texas Cardiac Arrhythmia
2021
St David's Medical Center
2021
Percutaneous coronary intervention (PCI) is increasingly used to treat unprotected left main artery stenosis, although coronary-artery bypass grafting (CABG) has been considered be the treatment of choice.We randomly assigned patients with stenosis undergo CABG (300 patients) or PCI sirolimus-eluting stents patients). Using a wide margin for noninferiority, we compared groups respect primary composite end point major adverse cardiac cerebrovascular events (death from any cause, myocardial...
Although intravascular ultrasound (IVUS) guidance has been useful in stenting for unprotected left main coronary artery stenosis, its impact on long-term mortality is still unclear.In the MAIN-COMPARE registry, patients with stenosis a hemodynamically stable condition underwent elective under of IVUS (756 patients) or conventional angiography (219 patients). Patients acute myocardial infarction were excluded. The 3-year outcomes between 2 groups primarily compared using propensity-score...
Several studies have compared the treatment effects of coronary stenting and coronary-artery bypass grafting (CABG). However, there are limited data regarding long-term outcomes these two interventions for patients with unprotected left main artery disease.We evaluated 1102 disease who underwent stent implantation 1138 CABG in Korea between January 2000 June 2006. We adverse (death; a composite outcome death, Q-wave myocardial infarction, or stroke; target-vessel revascularization) use...
Crohn's disease (CD) and ulcerative colitis (UC) are considered rare diseases in developing countries. We have evaluated the incidence prevalence of CD UC over time a district Seoul, Korea.A population-based study was performed from 1986 to 2005 Songpa-Kangdong Seoul. To recruit patients as completely possible, multiple information sources, including all medical facilities area 3 referral centers nearby but outside area, were used.During 20-year period, 138 incident cases (102 men, 36 women)...
Most trials comparing percutaneous coronary intervention (PCI) with coronary-artery bypass grafting (CABG) have not made use of second-generation drug-eluting stents.We conducted a randomized noninferiority trial at 27 centers in East Asia. We planned to randomly assign 1776 patients multivessel artery disease PCI everolimus-eluting stents or CABG. The primary end point was composite death, myocardial infarction, target-vessel revascularization 2 years after randomization. Event rates during...
The timing and indications for surgical intervention in asymptomatic patients with severe aortic stenosis remain controversial.In a multicenter trial, we randomly assigned 145 very (defined as an aortic-valve area of ≤0.75 cm2 either jet velocity ≥4.5 m per second or mean transaortic gradient ≥50 mm Hg) to early surgery conservative care according the recommendations current guidelines. primary end point was composite death during within 30 days after (often called operative mortality) from...
Background: Procedural results for percutaneous coronary intervention (PCI) in vessels with chronic total occlusion (CTO) have improved recent years, and PCI strategies moved toward more complete revascularization liberal use of CTO-PCI. However, evidence evaluating CTO-PCI is limited to observational studies small clinical trials. Methods: In this open-label, multicenter, randomized, noninferiority trial, PCI-eligible patients were assigned receive either 1 2 strategies: or no the...
Background— The optimal timing of surgical intervention in asymptomatic patients with severe mitral regurgitation is unclear. We therefore compared the long-term results early surgery a conventional treatment strategy. Methods and Results— From 1996 to 2005, 447 consecutive (253 men, age 50±15 years) degenerative preserved left ventricular function were evaluated prospectively. end point was defined as composite operative mortality, cardiac death, repeat valve surgery, urgent admission due...
Background: The morbidity and mortality of patients with functional mitral regurgitation (MR) remain high, but no pharmacological therapy has been proven effective. hypothesis this study was that sacubitril/valsartan would be superior to valsartan alone in improving MR via dual inhibition the renin-angiotensin system neprilysin. Methods: In double-blind trial, we randomly assigned 118 heart failure chronic secondary left ventricular (LV) dysfunction receive either or valsartan, addition...
The optimal timing of surgical intervention remains controversial in asymptomatic patients with very severe aortic stenosis. We therefore compared the long-term results early surgery and a conventional treatment strategy.From 1996 to 2006, we prospectively included total 197 consecutive (99 men; age, 63+/-12 years) Patients were excluded if they had angina, syncope, exertional dyspnea, ejection fraction <0.50, significant mitral valve disease, or age >85 years. Very stenosis was defined as...
Background— We assessed the optimal intravascular ultrasound (IVUS) stent area to predict angiographic in-stent restenosis (ISR) after sirolimus-eluting implantation for unprotected left main coronary artery (LM) disease. Methods and Results— A total of 403 patients treated with single- or 2-stent strategies (crushing T-stent) had immediate poststenting IVUS 9-month follow-up angiography. Poststenting minimal (MSA) was measured in each 4 segments: ostial anterior descending (LAD), circumflex...
Pregnancy intention is important for maternal and child health outcomes. The purpose of this study was to examine the causal relation between pregnancy depression parenting stress in Korean women who gave birth during 2008.This a retrospective evaluation prospectively collected data from Panel Study on Children 2008 2010. Causal analyses were conducted using propensity score matching inverse probability treatment weighted methods. In addition, mediation performed test mitigating effects...
Background: Owing to the differential propensity for bleeding and ischemic events with response antiplatelet therapy, safety effectiveness of potent P2Y12 inhibitor ticagrelor in East Asian populations remain uncertain. Methods: In this multicenter trial, 800 Korean patients hospitalized acute coronary syndromes or without ST elevation intended invasive management were randomly assigned receive, a 1:1 ratio, (180 mg loading dose, 90 twice daily thereafter) clopidogrel (600 75 thereafter)....
Long-term comparative outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents and coronary-artery bypass grafting (CABG) for left main artery disease are highly debated.In the PRECOMBAT trial (Premier of Randomized Comparison Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients Left Main Coronary Artery Disease), patients unprotected were randomly assigned to undergo PCI sirolimus-eluting (n=300) or CABG 13 hospitals Korea from April 2004...
Intravascular imaging-guided percutaneous coronary intervention (PCI) with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) showed superior clinical outcomes compared angiography-guided PCI. However, the comparative effectiveness of OCT-guided and IVUS-guided PCI regarding is unknown.In this prospective, multicenter, open-label, pragmatic trial, we randomly assigned 2008 patients significant artery lesions undergoing in a 1:1 ratio to undergo either an The primary end...
Importance An accurate noninvasive biomarker test is needed for the early diagnosis of bladder cancer. Objective To evaluate performance a urinary DNA methylation ( PENK methylation) and compare its diagnostic accuracy with that nuclear matrix protein 22 (NMP22) or urine cytology test. Design, Setting, Participants In this prospective multicenter study at 10 sites in Republic Korea, individuals 40 years older hematuria undergoing cystoscopy within 3 months between March 11, 2022, May 30,...
To determine whether changes in nutritional status the first week after acute ischemic stroke and undernutrition predicts poor clinical outcomes.Prospective observational study.Tertiary university hospital.We included 131 patients who underwent assessments within 24 hours at 1 symptom onset.Undernutrition was diagnosed when or more of following 5 parameters were present: (1) weight loss 10% during past 3 months 6% admission, (2) a index less than 80%, (3) serum albumin level 3.0 g/dL, (4)...
Background— We assessed optimal intravascular ultrasound (IVUS) criteria for predicting functional significance of intermediate coronary lesions. Methods and Results— Overall, 201 patients with 236 lesions underwent IVUS invasive physiological assessment before intervention. Fractional flow reserve (FFR) was measured at maximal hyperemia induced by intravenous adenosine infusion. FFR <0.80 maximum seen in 49 (21%) the overall The independent determinants were minimal lumen area (MLA;...
respectively).Using the cut-off value for strain ratio of 2.25, 17 out 22 patients (77.3%) with 3 or 4 EUS criteria CP had an abnormal pancreas, whereas 5 a <2.25.Importantly, even in epigastric pain, was significantly higher those finally diagnosed as (2.68, 95% CI 2.48-2.89)than whom disease excluded (1.80, 1.73-1.87;P < 0.0001).Using Rosemont classification, 99 (51.8%) were considered to have normal (11.5%) indeterminate CP, 45 (23.6%) suggestive and 25 (13.1%) consistent CP.The found be...