A5067351808- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Peripheral Artery Disease Management
- Mesenchymal stem cell research
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Atrial Fibrillation Management and Outcomes
- Pharmaceutical Economics and Policy
- Cerebrovascular and Carotid Artery Diseases
- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- 3D Printing in Biomedical Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
Korea University Medical Center
2016-2025
Korea University
2016-2025
Yonsei University
2020-2025
Hanmi Pharmaceutical (South Korea)
2023
Central Research Institute
2023
Sungkyunkwan University
2021-2022
Changwon National University
2022
Samsung (South Korea)
2022
Samsung Changwon Hospital
2022
Severance Hospital
2022
Intravascular imaging-guided percutaneous coronary intervention (PCI) with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) showed superior clinical outcomes compared angiography-guided PCI. However, the comparative effectiveness of OCT-guided and IVUS-guided PCI regarding is unknown.In this prospective, multicenter, open-label, pragmatic trial, we randomly assigned 2008 patients significant artery lesions undergoing in a 1:1 ratio to undergo either an The primary end...
While both sepsis-induced myocardial dysfunction (SIMD) and stress-induced cardiomyopathy (SICMP) are common in patients with sepsis, the pathogenesis of 2 diseases is different, they require different treatment strategies. Thus, we aimed to investigate risk factors outcomes between diseases.This retrospective study enrolled diagnosed sepsis or septic shock, admitted intensive care unit via emergency department Korea University Anam Hospital, who underwent transthoracic echocardiography...
The Korean Society of Lipid and Atherosclerosis (KSoLA) has published the Dyslipidemia Fact Sheets in Korea 2020 to provide an overview magnitude management status dyslipidemia their recent trends therein.The were based on analyses adults aged 20 years or older 2007-2018 National Health Nutrition Examination Survey (KNHANES) 2002-2018 Insurance Big Data (NHI-BD).Between 2007 2018, crude prevalence hypercholesterolemia increased from 9.0% 20.7%. During same period, its rate also improved yet...
The purpose of this study was to characterize the relationships among plasma adiponectin, essential hypertension, left ventricular diastolic function and hypertrophy.Plasma adiponectin concentration assessed by radioimmunoassay, body mass index (BMI) measured in 275 patients (138 women 137 men). Various echocardiographic parameters such as deceleration time (DT) isovolumetric relaxation (IVRT) were using echocardiograms. authors calculated (LVMI) E/A ratio. Pulse wave velocity (PWV) dividing...
It is still unclear whether low high-density lipoprotein cholesterol (HDL-C) affects cardiovascular outcomes after acute myocardial infarction (AMI), especially in patients with diabetes mellitus. A total of 984 AMI mellitus from the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND) Korean multicenter registry were divided into two groups based on HDL-C level admission: normal group (HDL-C ≥ 40 mg/dL, n = 519) and < 465). The primary endpoint was 2-year major adverse events (MACE),...
Introduction: Action potential duration restitution (APDR) plays a role in initiation and maintenance of ventricular tachycardia (VT)/ventricular fibrillation (VF). We hypothesized that the steeply sloped APDR its spatial heterogeneity contribute to VT/VF inducibility patients with arrhythmia. Method Results: After programmed stimulation (PVS) for evaluation clinically documented VT, (n = 20, 15 male, age 52.5 ± 9.5 years) were divided into two groups: inducible sustained (IVT, n 10)...
The aim of this study was to assess the effects percutaneous coronary intervention with drug-eluting stents (DESs) versus minimally invasive direct artery bypass (MIDCAB) surgery in management patients proximal left anterior descending (LAD) stenosis. Until recent years, despite advantages transluminal angioplasty (PTCA) bare metal stent implantation, such as shorter hospital stays and recovery time, MIDCAB showed better results regard need for repeated target vessel than PTCA LAD lesions....
To identify parameters influencing the likelihood of restenosis after implantation drug-eluting stents (DES) in patients with diabetes.Stented (n = 840) DES were retrospectively reviewed for inclusion study from Multicenter PCI Database Registry. From this database, 211 (25.1%) 840 six-month angiographic follow up had diabetes. Predictors coronary identified univariate and multivariate logistic regression analyses.Restenosis occurred 92 629 (14.6%) without diabetes 44 (20.9%) (p < 0.001)....
Although it has been demonstrated that visceral adipose tissue content and serum levels of adiponectin are associated with metabolic syndrome, their predictive potential for the development syndrome remains to be elucidated.We studied 1,130 participants Seoul Metabolic Syndrome cohort. A total 337 subjects without underwent follow-up evaluation finally analyzed. Visceral fat area (VFA) was measured using dual bioelectrical impedance analysis. We compared 1-year incidence rate among four...
Summary Aim We aimed to compare the effects of fixed‐dose combinations ezetimibe plus rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight‐week randomized double‐blind phase III study evaluated safety and efficacy 10 mg rosuvastatin, compared hypercholesterolemia. Four hundred seven hypercholesterolemia who required lipid‐lowering treatment according ATP guideline...
The human body contains different endothelial cell types and differences in their angiogenic potential are poorly understood. We compared the functional ability of aortic cells (HAECs) umbilical vein (HUVECs) using a three-dimensional (3D) microfluidic culture system. HAECs HUVECs exhibited similar cellular characteristics 2D system; however, 3D angiogenesis system, stronger than HUVECs. Interestingly, expression level fibroblast growth factor (FGF)2 FGF5 under vascular (VEGF)-A stimulation...
PurposeCombination therapy with ezetimibe and statins is recommended in cases of statin intolerance or insufficiency. The objective this study was to compare the efficacy safety combination rosuvastatin versus those monotherapy patients hypercholesterolemia.MethodsI-ROSETTE (Ildong ROSuvastatin & ezETimibe for hypercholesTElolemia) an 8-week, double-blind, multicenter, Phase III randomized controlled trial conducted at 20 hospitals Republic Korea. Patients hypercholesterolemia who required...
Although 1-stent with provisional approach is the preferred strategy for treatment of bifurcation lesions, optimal according to lesion location still debatable. This study aimed identify whether clinical outcomes differed between left main (LM) and non-LM lesions in second-generation drug-eluting stent era. The Coronary Bifurcation Stenting registry III a retrospective multicenter 2648 patients who underwent percutaneous coronary intervention stent. Among population, 935 (35.3%) had an LM...
Emerging evidence suggests that breast cancer stem cells (BCSCs), and epithelial-mesenchymal transition (EMT) may be involved in resistance to doxorubicin. However, it is unlear whether the doxorubicin-induced EMT expansion of BCSCs related dormancy, or outgrowing with maintaining doxorubicin, phenotypes can transferred other doxorubicin-sensitive cells. Here, we characterized phenotype doxorubicin-resistant TNBC while monitoring process CSCs during establishment MDA-MB-231 human (DRM...