A5042052666- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Vascular Procedures and Complications
- Mechanical Circulatory Support Devices
- Cardiovascular Syncope and Autonomic Disorders
- Peripheral Artery Disease Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
St. Vincent's Hospital
2016-2025
Catholic University of Korea
2012-2024
Seoul St. Mary's Hospital
2015-2024
National University College
2024
Asan Medical Center
2000-2024
University of Ulsan
2000-2024
Seoul National University Hospital
2015-2024
Ulsan College
2024
St Vincent Medical Center
2016
St Vincent Hospital
2016
BackgroundDespite consistent recommendations from clinical guidelines, data randomized trials on a long-term antithrombotic treatment strategy for patients with atrial fibrillation and stable coronary artery disease are still lacking.MethodsWe conducted multicenter, open-label, adjudicator-masked, trial comparing edoxaban monotherapy dual therapy (edoxaban plus single antiplatelet agent) in (defined as previously treated revascularization or managed medically). The risk of stroke was...
Importance The potential benefits of P2Y12 inhibitor deescalation for acute myocardial infarction after percutaneous coronary intervention may be influenced by body mass index (BMI). Objectives To investigate the association BMI on outcomes 12 months in patients with who were initially treated aspirin plus ticagrelor 1 month, and to assess whether BMI-based switching from (active control strategy) clopidogrel (deescalation is associated individualized benefits. Design, Setting, Participants...
Previous studies suggest that dipeptidyl peptidase-4 (DPP-4) inhibitors and sodium glucose cotransporter 2 (SGLT2) have different effects on the lipid profile in patients with type diabetes. We investigated of DPP-4 SGLT2 diabetes.From January 2013 to December 2015, a total 228 diabetes who were receiving inhibitor or as add-on therapy metformin and/or sulfonylurea consecutively enrolled. compared at baseline after 24 weeks treatment. To compare parameters between two groups, we used...
We investigated the association between severe hypoglycemia (SH) and risk of cardiovascular (CV) or all-cause mortality in patients with type 2 diabetes.The study included 1,260 aged 25 to 75 years diabetes from Vincent Type Diabetes Resgistry (VDR), who consecutively enrolled (n=1,260) January 2000 December 2010 were followed up until May 2015 a median follow-up time 10.4 years. Primary outcomes death any cause CV death. various covariates using Cox proportional hazards regression...
Calcineurin is a Ca<sup>2+</sup>/calmodulin-activated protein phosphatase that transduces hypertrophic stimuli to regulate transcriptional control of myocyte transformation. It not known whether overexpression MCIP1, recently described endogenous inhibitor calcineurin, impacts the response pathophysiologically relevant pressure overload. Further, functional consequences calcineurin inhibition by MCIP1 under conditions hemodynamic stress are unknown. Transgenic mice expressing human cDNA...
<h3>Objective</h3> β-blockers are the standard treatment for myocardial infarction (MI) based on evidence from pre-thrombolytic era. The aim of this study was to examine effect β-blocker in patients with acute MI and preserved systolic function era percutaneous coronary intervention (PCI). <h3>Methods</h3> We analysed a multicentre registry identified 3019 who presented between 2004 2009. Patients were treated PCI, had left ventricular EFs ≥50% according echocardiograms that performed during...
PurposeCombination therapy with ezetimibe and statins is recommended in cases of statin intolerance or insufficiency. The objective this study was to compare the efficacy safety combination rosuvastatin versus those monotherapy patients hypercholesterolemia.MethodsI-ROSETTE (Ildong ROSuvastatin & ezETimibe for hypercholesTElolemia) an 8-week, double-blind, multicenter, Phase III randomized controlled trial conducted at 20 hospitals Republic Korea. Patients hypercholesterolemia who required...
Objective: Coronary angiography (CAG) is the gold standard method in evaluating graft patency following coronary artery bypass grafting (CABG), even though there are several kinds of non-invasive methods. Recently developed multi-slice CT (m-CT), having effective scan times up to 0.25 s and multi-row detector array systems, enable rapid imaging cardiac structures, including arteries during one breath-hold. We compared m-CT with CAG for evaluation CABG. Methods: Forty-two patients undergone...
Abstract Aims We investigated whether cardiovascular autonomic neuropathy (CAN) is associated with acute ischaemic stroke in patients Type 2 diabetes. Methods From 1999 to 2000, function tests were conducted diabetes ( n = 1458). Patients followed up between 2006 and 2007. Standard for CAN measured heart rate variability parameters [expiration‐to‐inspiration (E/I) ratio, responses the Valsalva manoeuvre standing]. Using American Diabetes Association criteria, scores determined from results...
<h3>Background</h3> A low level of high-density lipoprotein cholesterol (HDL-C) is strongly associated with cardiovascular events. However, the significance HDL-C after statin therapy on outcome patients who have undergone percutaneous coronary intervention (PCI) drug eluting stents (DES) unclear. <h3>Objectives</h3> To investigate events in artery disease DES implantation. <h3>Methods</h3> Patients underwent PCI from January 2004 to December 2009 were prospectively enrolled. The follow-up...
Home blood pressure (BP) monitoring offers clinically relevant information enriched with more abundant data. However, there are few studies addressing the reliability of home BP devices and quality its This study aimed to evaluate current status in terms validation accuracy.Hypertensive patients automated upper arm-type were consecutively enrolled. First, each device was assessed through website. Next, accuracy individual evaluated by comparing mean values between a mercury sphygmomanometer....
Cardiovascular autonomic neuropathy (CAN) is a risk factor for cardiovascular disease (CVD) and mortality in patients with type 2 diabetes. This study evaluated the relationship between CAN recurrent CVD A total of 206 diabetes who had history within 3 years enrollment were consecutively recruited from January 2001 to December 2009 followed-up until 2015. function tests performed using following heart rate variability parameters: expiration-to-inspiration ratio, response Valsalva maneuver...
Little is known about the characteristics and long-term clinical outcomes of patients with heart failure improved ejection fraction (HFimpEF) after acute myocardial infarction.
Hypertrophic growth of the myocardium occurs in most forms heart failure and may contribute to pathogenesis state. Little is known about regulatory mechanisms governing often-coexisting phenotypes hypertrophy, systolic failure, diastolic stiffness that characterize clinical disease. We hypothesized intracellular signaling pathways are differentially activated by graded degrees hemodynamic stress. To test this, we developed models pressure stress mice used them directly compare compensated...
OBJECTIVE The aim of this study was to investigate the development severe hypoglycemia (SH) in presence cardiovascular autonomic neuropathy (CAN) patients with type 2 diabetes. RESEARCH DESIGN AND METHODS From January 2001 December 2002, a total 894 diabetes were enrolled. A function test (AFT) performed using following heart rate variability parameters: expiration-to-inspiration ratio, response Valsalva maneuver, and standing. results for each three tests (0 normal, 1 abnormal), AFT score...
We aimed to compare the long-term clinical outcomes between fractional flow reserve (FFR)-guided and routine drug-eluting stent (DES) implantation in patients with an intermediate coronary stenosis. A total of 229 angiographically stenosis were randomly assigned FFR-guided or Routine-DES group. For group (n=114), treatment strategy was determined according target vessel FFR (FFR<0.75: DES [FFR-DES group]; FFR≥0.75: deferral stenting [FFR-Defer group]). underwent without measurement (n=115)....
The no-reflow phenomenon is a potential complication of primary percutaneous coronary intervention (PCI). Predictors the and impact on long-term mortality remain unclear.Two thousand seventeen patients with ST-segment elevation myocardial infarction (STEMI) who had undergone PCI were consecutively enrolled in multicentre Acute Myocardial Infarction registry Korea. was diagnosed basis angiographic criteria. outcome all-cause mortality.The 262 (13.0%). Independent predictors older age, high...
Abstract Aims We investigated the association between lipoprotein(a) [Lp(a)] level and new‐onset chronic kidney disease ( CKD ) in patients with Type 2 diabetes. Methods conducted a prospective cohort study from March 2003 to December 2004 median follow‐up time of 10.1 years. Patients aged 25–75 years diabetes without [estimated glomerular filtration rate eGFR ≥ 90 ml/min/1.73 m were consecutively enrolled. The was measured at least twice every year , defined as decreased status < 60...
Aims: In patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI), the risk of ischaemic complications is highest in early phase (during first 30 days), while most bleeding events occur predominantly during maintenance treatment (after days). Data on de-escalation dual antiplatelet therapy by switching from ticagrelor to clopidogrel stabilised AMI are limited. The aim this study investigate efficacy and safety with no adverse event month after index...