A5057827830- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Cardiomyopathy and Myosin Studies
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Muscle Physiology and Disorders
- Advanced Glycation End Products research
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Pharmaceutical Economics and Policy
- Pericarditis and Cardiac Tamponade
- Heart Rate Variability and Autonomic Control
Gangnam Severance Hospital
2016-2025
Yonsei University
2016-2025
University of Maryland, Baltimore
2024-2025
SHARE
2024
Science Health Allied Research Education
2024
Singapore-HUJ Alliance for Research and Enterprise
2024
Wonju Severance Christian Hospital
2023
Korea University
2023
Lodestar Research Corporation (United States)
2023
Weatherford College
2021
Intravascular imaging-guided percutaneous coronary intervention (PCI) with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) showed superior clinical outcomes compared angiography-guided PCI. However, the comparative effectiveness of OCT-guided and IVUS-guided PCI regarding is unknown.In this prospective, multicenter, open-label, pragmatic trial, we randomly assigned 2008 patients significant artery lesions undergoing in a 1:1 ratio to undergo either an The primary end...
In patients with coronary artery disease, some guidelines recommend initial statin treatment high-intensity statins to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). An alternative approach is begin moderate-intensity and titrate specific LDL-C goal. These alternatives have not been compared head-to-head clinical trial involving known disease.To assess whether treat-to-target strategy noninferior of for long-term outcomes disease.A randomized, multicenter,...
Summary Aim We aimed to compare the effects of fixed‐dose combinations ezetimibe plus rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight‐week randomized double‐blind phase III study evaluated safety and efficacy 10 mg rosuvastatin, compared hypercholesterolemia. Four hundred seven hypercholesterolemia who required lipid‐lowering treatment according ATP guideline...
P2Y12 inhibitor monotherapy after dual antiplatelet therapy (DAPT; a plus aspirin) for brief duration has recently emerged as an attractive alternative patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent.
This study aimed to evaluate the efficacy and safety of triple combination ezetimibe (Eze)/atorvastatin (Ato) 10/40 mg + amlodipine (Aml) 10 therapy for lowering low-density lipoprotein cholesterol (LDL-C) blood pressure compared with either Eze/Ato or Aml therapies in patients comorbid primary hypercholesterolemia essential hypertension. was a randomized, multicenter, double-blind, active-controlled, Phase III clinical trial. Participants underwent wash-out period (2 weeks nonfibrate...
Small dense LDL (sd-LDL) has recently emerged as an important coronary artery disease (CAD) risk factor. This study was performed to investigate how particle size is related CAD and acute syndrome (ACS). Blood samples were collected from 504 patients that underwent angiography evaluate chest pain. The of these measured. mean smaller in with angiographically proven than the controls (26.41 +/- 0.95 vs 26.73 0.64 nm, p < 0.001), negatively correlated Framingham score (r=-0.121, p=0.007)....
<i>Background:</i> The pathophysiological role and metabolic pathway of Lp(a) have not been clearly defined. An association between oxidative low-density lipoprotein (LDL) were recently reported. And small dense LDL (sd-LDL) associated with circulating malondialdehyde-modified LDL. We investigated the relationships serum level particle size in coronary artery disease (CAD) patients. Further, we sd-LDL extent severity CAD. <i>Methods:</i> A total 490 patients (mean:...
Advanced glycation endproducts (AGEs)-induced vascular smooth muscle cell (VSMCs) proliferation and formation of reactive oxygen species (ROS) are emerging as one the important mechanisms diabetic vasculopathy but little is known about antioxidative action HMG CoA reductase inhibitor (statin) on AGEs. We hypothesized that statin might reduce AGEs-induced intracellular ROS VSMCs analyzed possible mechanism in cellular signaling. Aortic Sprague-Dawley rat (RASMC) culture was done using...
Two-Phase Reconstruction for the Assessment of Left Ventricular Volume and Function Using Retrospective ECG-Gated MDCT: Comparison with EchocardiographyTae Hoon Kim1, Jin Hur1, Sang Hyun Soo Byoung Wook Choi1, Kyu Ok Choe1, Young Won Yoon2 Hyuck Moon Kwon2Audio Available | Share
Pulmonary artery intimal sarcoma is a rare highly lethal disease, with additional retrograde extension to pulmonic valve and right ventricle being an extremely condition. It frequently mistaken for pulmonary thromboembolism. We report case of 64-year-old woman progressive dyspnea initially suspected treated Her helical chest CT scan 3 dimensional (3D) reconstruction combined echocardiography revealed compacting main mass extending the ventricular outflow tract artery. After excision mass,...
Advanced glycation endproducts (AGEs) have been reported to play a role in neointimal formation and increase the rate of in-stent restenosis (ISR) diabetic coronary artery disease patients treated with stents, but potential pathogenic mechanisms AGEs vascular smooth muscle cell proliferation remain unclear. We sought determine related pathobiological mechanism vasculopathy. Rat aortic (RAoSMC) culture was done different concentrations assessed. Immunohistochemistry for receptor (RAGE)...
Prognostic value of additional carotid Doppler evaluations to intima-media thickness (IMT) and plaque has not been completely evaluated.A total 1119 patients with risk factors for, but without, overt coronary artery disease (CAD), who underwent both ultrasound examination were included in the present study. Parameters interest peak systolic end-diastolic velocities, resistive indices arteries, IMT, measurements. The primary end-point was all-cause cerebro-cardiovascular events (CVEs)...
Lipoprotein a (Lp (a)) and coronary artery calcification (CAC) are markers of cardiovascular diseases. However, the association between Lp (a) CAC in asymptomatic individuals remains unclear. In this study, we aimed to determine influence on individuals.We included 2019 Korean adults who underwent testing for calcium score (CACS) at Gangnam Severance Hospital Health Checkup Center Korea from January 2017 August 2019. Participants were divided into 2 groups: CACS = 0 > 0. Factors affecting...
Angiography remains the gold standard for guiding percutaneous coronary intervention (PCI). However, it is prone to suboptimal stent results due visual estimation of measurements. Although benefit intravascular ultrasound (IVUS)-guided PCI becoming increasingly recognised, IVUS not affordable many catheterisation laboratories. Thus, a more practical and standardised angiography-based approach necessary support implantation.