A5029960265- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Pericarditis and Cardiac Tamponade
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
Yonsei University
2016-2025
Yonsei University Health System
2015-2024
Severance Hospital
2015-2024
Gangnam Severance Hospital
2015-2024
Myongji Hospital
2024
Cedars-Sinai Medical Center
2023
Chungnam National University Hospital
2023
University Health System
2015-2020
General Electric (Norway)
2015-2018
Keimyung University Dongsan Medical Center
2018
The timing and indications for surgical intervention in asymptomatic patients with severe aortic stenosis remain controversial.In a multicenter trial, we randomly assigned 145 very (defined as an aortic-valve area of ≤0.75 cm2 either jet velocity ≥4.5 m per second or mean transaortic gradient ≥50 mm Hg) to early surgery conservative care according the recommendations current guidelines. primary end point was composite death during within 30 days after (often called operative mortality) from...
Background: The morbidity and mortality of patients with functional mitral regurgitation (MR) remain high, but no pharmacological therapy has been proven effective. hypothesis this study was that sacubitril/valsartan would be superior to valsartan alone in improving MR via dual inhibition the renin-angiotensin system neprilysin. Methods: In double-blind trial, we randomly assigned 118 heart failure chronic secondary left ventricular (LV) dysfunction receive either or valsartan, addition...
Background— Recent evolution of cardiac computed tomography (CT) provides useful information about valvular and perivalvular structures. We compared the diagnostic performance CT transesophageal echocardiography (TEE) with applications 3-dimensional reconstruction in detecting vegetation intracardiac complications patients infective endocarditis (IE). Methods Results— Seventy-five (53 men; age, 58±15 years) definite IE who underwent TEE within 3 days were analyzed. The performances 2...
Recent studies have reported improved diastolic function in patients administered sodium-glucose cotransporter 2 inhibitors (SGLT2i). We aimed to investigate the effect of dapagliflozin on left ventricular (LV) a diabetic animal model and determine molecular cellular mechanisms underlying its function.A total 30 male New Zealand white rabbits were randomized into control, diabetes, or diabetes+dapagliflozin groups (n = 10/per each group). Diabetes was induced by intravenous alloxan. Cardiac...
The aim of this study is to explore the differential effect 3-dimensional color Doppler echocardiography for quantification mitral regurgitation (MR). Two-dimensional echocardiography-based MR has well-documented limitations.We consecutively enrolled 221 patients with MR. Adequate image quality was obtained by 2D- and 3D-color in 211 (95.5%) patients. quantitative differences between volumes 3D-proximal isovelocity surface area (PISA) were analyzed various subgroups. In validation cohort...
Stiffening of large arteries can result in changes cardiac structure and function by increasing afterload to the left ventricle. Calcification has been proposed as a mechanism underlying progression arterial stiffening. The aim current study was investigate relationship between aortic calcification, stiffening, ventricular hypertrophy, diastolic dysfunction.One hundred sixty-four hypertensive elderly (≥65 years old) male patients with normal systolic (left ejection fraction ≥55%) underwent...
Objectives Malignant pericardial effusion (MPE) in patients with cancer is associated poor prognosis. This study aimed to compare clinical outcomes who underwent pericardiocentesis versus window formation. Methods In the present study, 765 consecutive (mean age 58.4 years, 395 men) drainage between 2003 and 2022 were retrospectively analysed. All-cause death MPE recurrence compared based on method (pericardiocentesis vs formation) time period (period 1: 2003–2012; 2: 2013–2022). Results...
TRI-SCORE was recently developed in Europe as a risk model for predicting in-hospital death after isolated tricuspid valve surgery. We aimed to validate an Asian population and investigate its value long-term outcomes.
Background: The current study was designed to investigate the correlation between left ventricular (LV) vortex flow pattern and LV apical thrombus formation in patients with acute anterior wall myocardial infarction (MI). Methods Results: Fifty-seven MI were enrolled this study. Eighteen (thrombus group) 39 without (non-thrombus underwent 2-dimensional contrast echocardiography (CE). Morphology pulsatility parameters of measured using Omega flow® compared 2 groups. In group, located more...
Cerebral small vessel disease (SVDs) are related with large artery atherosclerosis. However, the association between aortic atheroma (AA) and cerebral has rarely been reported. This study evaluated relationship presence burden of AAs those SVDs in patients acute ischemic stroke.We included 737 consecutive who underwent transesophageal echocardiography (TEE) brain magnetic resonance imaging (MRI) for evaluation stroke. AA subtypes were classified as complex plaque (CAP) simple (SAP). Presence...
Unprovoked venous thromboembolism (VTE) is related to a higher incidence of occult cancer. D-dimer clinically used for screening VTE, and has often been shown be present in patients with malignancy. We explored the predictive value detecting cancer unprovoked VTE.We retrospectively examined data from 824 diagnosed deep vein thrombosis or pulmonary thromboembolism. Of these, 169 (20.5%) VTE were selected participate this study. was categorized into three groups as: <2,000, 2,000-4,000, >4,000...
This study aimed to investigate the prevalence and clinical significance of lead-related tricuspid regurgitation (TR) in patients with permanent pacemaker (PM). A total 2,533 who underwent PM implantation between January 2008 December 2017 a single center were retrospectively reviewed. Among them, 429 transthoracic echocardiography within 90 days before followed up at least 3 months after included. Patients had pre-existing grade or 4 TR, atrial lead, undergone valve surgery excluded....
New methods based on nonlinear theory have been developed to give more insight into complex heart rate (HR) dynamics. This study was designed test the hypothesis that altered HR dynamics, as analyzed with complexity and fractal measures, may precede spontaneous onset of paroxysmal atrial fibrillation (PAF). Secondly, difference in temporal change these measurements between different types (AF) assessed.From 105 Holter tapes which PAF recorded, 44 (>or=5 min) episodes 33 patients (22 men, 58...
The purpose of this study was to investigate the effects dexmedetomidine on biventricular systolic and diastolic function using transoesophageal echocardiography. Cardiac assessed in 30 healthy patients who received total intravenous anaesthesia with propofol remifentanil. echocardiographic examinations were performed just before 20, 40 60 min after or saline administration. Patients dexmedetomidine, compared 20 min, had a lower mean (SD) heart rate (56.7 (5.2) vs. 67.1 (7.1) beats.min(-1)...
Background and Purpose— The evaluation of sources cardioembolism with transesophageal echocardiography (TEE) in patients stroke is crucial but semi-invasive. We hypothesized that the size mechanical function left atrium (LA) assessed by transthoracic (TTE) could provide useful information on high risk TEE stroke. Furthermore, we sought to define determinants LA dysfunction these patients. Methods— A total 248 acute ischemic (147 men; 64±13 years) who underwent 2-dimensional speckle tracking...
The risk of stroke imposed by atrial fibrillation (AF) is significantly greater in women than men; however, the mechanism remains elusive. We hypothesized that left (LA) remodeling and poor contractile function LA appendage (LAA) would be more predominant men among AF patients.A total 579 patients (216 vs age-, type-, incidences heart failure, hypertension, diabetes mellitus, or transient ischemic attack, vascular disease-matched 363 men, 61.3±10.2 years old, 70.1% paroxysmal AF) who...