A5100743828- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Lung Cancer Diagnosis and Treatment
- Ecology and Conservation Studies
- Food Quality and Safety Studies
- Radiomics and Machine Learning in Medical Imaging
- Economic and Environmental Valuation
- Metabolism, Diabetes, and Cancer
- Virus-based gene therapy research
- Medical Imaging and Pathology Studies
- Cardiac electrophysiology and arrhythmias
- Lung Cancer Research Studies
- Pluripotent Stem Cells Research
- Cardiac pacing and defibrillation studies
- Adipose Tissue and Metabolism
- Agriculture, Soil, Plant Science
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Effects of Exercise
Severance Hospital
2016-2025
Yonsei University
2016-2025
Korea Research Institute of Bioscience and Biotechnology
2019-2025
Biotechnology Research Center
2025
Konkuk University
2013-2024
Chung-Ang University
2024
Seoul St. Mary's Hospital
2020-2024
Catholic University of Korea
2020-2024
Gangnam Severance Hospital
2019-2024
Bucheon St. Mary's Hospital
2024
Heart failure remains a major public health concern with 5-year mortality rate higher than that of most cancers. Myocardial disease in heart is frequently accompanied by impairment the specialized electrical conduction system and myocardium. We introduce an epicardial mesh made electrically conductive mechanically elastic material, to resemble innate cardiac tissue confer function, enable electromechanical cardioplasty. Our epicardium-like substrate integrated acted as structural element...
AMP-activated protein kinase (AMPK) functions as an energy sensor to provide metabolic adaptations under the ATP-deprived conditions such hypoxia. In present study, we considered a role of AMPK in adaptive response hypoxia by examining whether is involved regulation hypoxia-inducible factor-1 (HIF-1), heterodimeric transcription factor that critical for hypoxic induction physiologically important genes. We demonstrate or CoCl2 rapidly activated DU145 human prostate cancer cells, and its...
Multiarmed nonlinear optical (NLO) molecules containing triphenylamine as a core and 4-(2-ethylhexylsulfonyl)benzene-(1E)-2-vinyl group or 4-{2-[4-(2-ethylhexylsulfonyl)phenyl]-(1E)-vinyl}benzene-(1E)-2-vinyl arms were synthesized (STEH series SSEH series, respectively). Because linked to the sulfonylated stilbenic provided effective push−pull NLO structure strong 2-D charge transfer, they capable of both two-photon absorption (TPA) photorefraction. Effective TPA cross sections these high...
Purpose To evaluate the feasibility of equilibrium contrast material–enhanced dual-energy cardiac computed tomography (CT) to determine extracellular volume fraction (ECV) in nonischemic cardiomyopathy (CMP) compared with magnetic resonance (MR) imaging. Materials and Methods This study was approved by institutional review board; informed consent obtained. Seven healthy subjects 23 patients (six hypertrophic CMP, nine dilated four amyloidosis, sarcoidosis) (mean age ± standard deviation,...
To assess the diagnostic accuracy of two-phase 64-section cardiac computed tomographic (CT) angiography for detection left atrial appendage (LAA) thrombi and differentiation between thrombus circulatory stasis in patients with stroke, transesophageal echocardiography (TEE) as reference standard.This study was institutional review board approved, all gave written informed consent. Fifty-five consecutive (36 men, 19 women; mean age, 61 years) who had recently experienced a high-risk factors...
As lysosomal hydrolysis has long been suggested to be responsible for myelin clearance after peripheral nerve injury, in this study, we investigated the possible role of autophagolysosome formation phagocytosis by Schwann cells and its final contribution regeneration. We found that canonical autophagolysosomes was induced demyelinating inhibition autophagy via cell‐specific knockout atg7 gene or pharmacological intervention function caused a significant delay clearance. However, cell...
To assess the diagnostic performance of dual-energy cardiac computed tomography (CT) in detection left atrial appendage (LAA) thrombi and differentiation between thrombus circulatory stasis patients with stroke, by using transesophageal echocardiography (TEE) as reference standard.The institutional review board approved this study, provided informed consent. Thirty-two stroke who had fibrillation (AF) either or spontaneous echo contrast (SEC) pattern at TEE were prospectively enrolled. For...
Purpose We obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion‐weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these and histological microvessel density (MVD) for the possibility of noninvasive evaluation MVD with DWI. Methods Twenty‐five nude mice HT29 colorectal cancer cells implanted were analyzed after undergoing DWI values (0, 50, 100, 300, 500, 700, 1000 s/mm 2 ). Tissue diffusivity ( D t ),...
A noninvasive method with high reliability and accuracy comparable to transesophageal echocardiography for identification of left atrial appendage thrombus would be significant clinical value. The aim this study was assess the diagnostic performance a dual-enhanced cardiac CT protocol detection thrombi differentiation between circulatory stasis in patients stroke.We studied 83 consecutive stroke (56 men 27 women; mean age, 62.6 years) who had risk factors formation undergone both dual-source...
Background —Familial hypercholesterolemia (FH) that results from LDL receptor (LDLR) deficiency affects ≈1 in 500 persons the heterozygous state and 1 million homozygous state. We tested a novel gene therapy strategy for treatment of FH mouse model. Methods Results —We delivered VLDL (VLDLR) to liver LDLR-deficient mice compared effect helper-dependent adenoviral vector with all viral coding sequences deleted (HD-Ad-mVLDLR) first-generation (FG-Ad-mVLDLR), an HD-Ad (HD-Ad-0) contained no...
To classify anomalous origins of the right coronary artery (RCA) from left sinus (AORL) with an interarterial course into two subtypes and to evaluate clinical importance each.Institutional review board approval was obtained for this retrospective study, informed consent waived. Through a 22,925 consecutive cardiac computed tomographic (CT) scans, 124 cases AORL were identified. These anomalies classified according location RCA ostium: high (between aorta pulmonary artery) low ventricular...
The purpose of this study was to evaluate the diagnostic performance CT fluoroscopy-guided percutaneous needle aspiration biopsy ground-glass opacity (GGO) pulmonary lesions.Twenty-eight patients with GGO lesions who underwent were enrolled in study. divided into three groups according their size: group 1, < or = 10 mm (n 10); 2, 11-20 and 3, > 20 8). Sensitivity, specificity, accuracy calculated on basis 28 results compared among using Fisher's exact test. Diagnostic also length path (< 5...
<h3>Objective</h3> To investigate clinical outcomes of exercise-induced pulmonary hypertension (PH) and implications an increase in left ventricular (LV) filling pressure during exercise subjects with preserved LV ejection fraction. <h3>Design</h3> Longitudinal follow-up study. <h3>Setting</h3> Subjects who were referred for diastolic stress echocardiography. <h3>Patients methods</h3> The ratio transmitral annular velocities (E/Ea) artery systolic (PASP) at rest measured 498 (57±11 years;...
A specific morphology of left atrial appendage (LAA) has been reported to be related stroke in nonvalvular fibrillation (AF) patients. However, the mechanism is not completely understood. This study evaluated whether a LAA was stroke, and it change flow velocity size AF patients.The morphology, size, were patients with ischemic strokes (stroke, n = 160) age-matched without (control, 200).Compared control, group had larger LA dimension (4.5 ± 0.7 vs. 4.2 0.6 cm, P < 0.001), orifice area (5.3...
Background We aimed to assess if quantitative radiomic features can predict programmed death ligand 1 (PD‐L1) expression in advanced stage lung adenocarcinoma. Methods This retrospective study included 153 patients who had (>IIIA by TNM classification) adenocarcinoma with pretreatment thin section computed tomography (CT) images and PD‐L1 test results their pathology reports. Clinicopathological data were collected from electronic medical records. Visual analysis feature extraction of the...
EGFR mutation-induced cell proliferation causes changes in tumor biology and metabolism, which may reflect marker concentration 18F-FDG uptake on PET/CT. Direct aspirates of primary lung tumors contain different concentrations markers than serum markers, correlate better with mutation markers. The purpose this study is to investigate an association between cytologic FDG status non-small cancer (NSCLC). We prospectively collected 61 patients who underwent analysis. Serum CYFRA 21-1, CEA, SCCA...
To evaluate the clinical feasibility and accuracy of 64-section multidetector computed tomography (CT) compared with transesophageal echocardiography (TEE) for diagnosis a patent foramen ovale (PFO).Institutional review board approval was obtained this retrospective study. The study included 152 consecutive stroke patients (mean age, 61.7 years; 98 men, 54 women) who underwent both cardiac CT TEE. Electrocardiographically gated performed scanner by using saline-chaser contrast agent...
We assessed the diagnostic performance of 2-phase 64-slice cardiac computed tomographic angiography (CCTA) for detection a source embolism in stroke patients using transesophageal echocardiography (TEE) as reference standard.We selected 137 who had experienced recent episode and undergone both CCTA TEE within period 5 days. A potential detected at was recorded, echocardiographic findings were categorized into high- medium-risk sources based on TOAST (Trial Org 10172 Acute Stroke Treatment)...