A5035784882- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Prion Diseases and Protein Misfolding
- Endoplasmic Reticulum Stress and Disease
- Tea Polyphenols and Effects
- Pharmacological Effects of Natural Compounds
- RNA regulation and disease
- Cell Adhesion Molecules Research
- Autophagy in Disease and Therapy
- Bone Metabolism and Diseases
- melanin and skin pigmentation
- Pancreatic function and diabetes
- Biochemical Analysis and Sensing Techniques
- Skin Protection and Aging
- Antioxidant Activity and Oxidative Stress
- Natural product bioactivities and synthesis
- Clusterin in disease pathology
- Angiogenesis and VEGF in Cancer
- Phytochemistry and Bioactive Compounds
- Bone health and treatments
- Phytochemicals and Antioxidant Activities
- Advanced Glycation End Products research
- Nuclear Structure and Function
- RNA Research and Splicing
- Regulation of Appetite and Obesity
Ulsan College
2012-2022
University of Ulsan
2012-2022
Asan Medical Center
2014-2022
Seoul Veterans Hospital
2016
Hallym University
2005-2012
Food & Nutrition
2011
Hallym Polytechnic University
2009
Kangwon National University
2009
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2007-2008
National Institutes of Health
2006-2008
The preemptive quality control (pQC) pathway protects cells from acute endoplasmic reticulum (ER) stress by attenuating translocation of nascent proteins despite their targeting to translocons at the ER membrane. Here, we investigate hypothesis that DnaJ protein p58(IPK) plays an essential role in this process via HSP70 recruitment cytosolic face for extraction translocationally attenuated chains. Our analyses revealed heightened sensitivity p58-/- was not due impairment pQC or elevated...
Please cite this paper as: Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV‐B irradiation. Experimental Dermatology 2010; 19 : e182–e190. Abstract: Ellagic acid, a polyphenol present in berries pomegranate, has received attention as an agent that may have potential bioactivities preventing chronic diseases. This study examined photoprotective effects of on collagen breakdown inflammatory responses UV (ultraviolet)‐B irradiated human cells hairless mice....
Islet amyloid accumulation is a hallmark of human type 2 diabetes (T2D). In contrast to islet polypeptide (hIAPP), murine (mIAPP) does not exhibit amyloidogenic propensity. Because autophagy important in the clearance amyloid-like proteins, we studied transgenic mice with β cell–specific expression hIAPP evaluate contribution T2D-associated hIAPP. hIAPP, deficiency resulted development overt diabetes, which was observed expressing alone or lacking alone. Furthermore, lack hIAPP-expressing...
Calcification of the aortic valve leads to increased leaflet stiffness and consequently development calcific disease. However, underlying molecular cellular mechanisms calcification remain unclear. Here, we identified that dipeptidyl peptidase-4 (DPP-4, also known as CD26) increases valvular promotes disease progression.We obtained tissues from humans murine models (wild-type endothelial nitric oxide synthase-deficient-mice) cultured interstitial cells (VICs) cusps. We induced osteogenic...
Obesity-induced insulin resistance and diabetes are significantly associated with infiltrates of inflammatory cells in adipose tissue. Previous studies recognized the involvement autophagy regulation metabolism multiple tissues, including β-cells, hepatocytes, myocytes, adipocytes. However, despite importance macrophages obesity-induced resistance, role macrophage regulating sensitivity is seldom addressed. In present study, we show that important for systemic sensitivity. We found...
The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune-modulatory involved in phagocytosis and inflammation. Mutations of Q33X, Y38C T66M cause Nasu-Hakola disease (NHD) which characterized by early onset dementia bone cysts. A recent, genome-wide association study also revealed that single nucleotide polymorphism TREM2, such as R47H, increased the risk Alzheimer's (AD) similar to ApoE4. However, how these mutations affect trafficking may normal functions was not known. In...
Beclin-1 plays a critical role in autophagy; however, it also contributes to other biological processes non-autophagic manner. Although studies have examined the of autophagy proteins secretory function osteoclasts (OC), is unclear. Here, we OC differentiation, and found that mouse bone marrow macrophages (BMMs) showed increased expression upon RANKL stimulation p38- NF-kappa B-dependent During localized mitochondria, where was involved production mitochondrial intracellular reactive oxygen...
Vaspin is an adipocytokine that was recently identified in the visceral adipose tissue of diabetic rats and has anti-diabetic anti-atherogenic effects. We hypothesized vaspin prevents inflammatory cytokine-induced nuclear factor-kappa B (NF-κB) activation by activating AMP-activated protein kinase (AMPK) vascular endothelial cells. examined effects on NF-κB expression NF-κB-mediated genes intercellular adhesion molecule-1 (ICAM-1), cell (VCAM-1), E-selectin, monocyte chemoattractant...
Pentraxin 3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity malignancies, but its exact role remains unclear. This study found that PTX3 expression was up-regulated in distant bone metastases breast cancer compared lung, liver, brain 64 human patients. Elevated poor survival patients cancer. also metastatic cell line further enhanced by pro-inflammatory cytokine TNFα. Administration promoted the migratory potential...
Melanogenesis is a critical self-defense mechanism against ultraviolet radiation (UVR)-induced skin damage and carcinogenesis; however, dysregulation of melanin production distribution causes skin-disfiguring pigmentary disorders.Melanogenesis initiated by UVR-induced cAMP generation ensuing activation transcription factor CREB, which induces expression the master melanogenic regulator MITF.Recent studies have demonstrated that recruitment CRTCs to CREB complex also required for...
High plasma level of cholesterol is a well-known risk factor for atherosclerotic diseases. Oxidized LDL induces cellular and nuclear damage that leads to apoptotic cell death. We tested the hypothesis flavonoids may function as antioxidants with regard incubated 5 μm-Cu 2+ alone or in combination human umbilical vein endothelial cells (HUVEC). Cytotoxicity formation thiobarbituric acid-reactive substances induced by Cu -oxidized were examined presence various subtypes flavonoid. Flavanols,...
Diabetic nephropathy characterized as mesangial fibrosis and glomerulosclerosis results in renal failure end-stage diseases. Enhanced expression secretion of connective tissue growth factor (CTGF) play an important role the expansion glomerular matrix mostly composed type IV collagen. Isoliquiritigenin can prevent various injuries via its anti-inflammatory action. However, effect isoliquiritigenin on diabetic has never been explored. The present study was to investigate whether nontoxic...
Bone-remodeling imbalance induced by decreased osteoblastogenesis and increased bone resorption is known to cause skeletal diseases such as osteoporosis. Silibinin the major active constituent of silymarin, mixture flavonolignans extracted from blessed milk thistle (Silybum marianum). Numerous studies suggest that silibinin a powerful antioxidant has anti-hepatotoxic properties anti-cancer effects against carcinoma cells. This study investigated had bone-forming osteoprotective in vitro cell...
Oxidative modification of LDL is causally involved in the development atherosclerosis and occurs vivo blood as well within vascular wall. The present study attempted to explore whether polyphenolic flavonoids influence monocyte-endothelium interaction lectin-like oxidised receptor 1 (LOX-1) expression early atherosclerosis. flavones luteolin apigenin inhibited THP-1 cell adhesion onto LDL-activated human umbilical vein endothelial cells (HUVEC), while flavanols ( − )epigallocatechin gallate...